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| Number | Title | Issue Date |
| 7955059 | Fluid control device for a high pressure analytical instrument In various embodiments a fluid control device suitable for high pressure analytical instruments includes a housing having an interior surface with an end wall. The interior surface defines a chamber. A valve assembly disposed in the chamber controls the flow of flui... | 06/07/2011 |
| 7938961 | Capillary loop with a built-in retaining frit Disclosed herein are an apparatus and method for effectuating increased chromatographic efficiency in a capillary column by employing a retaining frit disposed within an analytical capillary. By disposing the retaining frit within the analytic capillary, the void vo... | 05/10/2011 |
| 7911609 | Evaporative light scattering detector Embodiments of the present invention are directed to evaporation light scattering detectors having an evaporative chamber having a wall that is in good thermal contact with a heat sink. The heat has a high thermal mass such that a change in temperature of the wall d... | 03/22/2011 |
| 7909367 | Capillary interconnection fitting and method of holding capillary tubing The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw an... | 03/22/2011 |
| 7897917 | Methods and apparatus for performing chromatography and mass spectroscopy with supercritical fluid samples Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one... | 03/01/2011 |
| 7888637 | Sample preparation plate for mass spectrometry Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a s... | 02/15/2011 |
| 7847936 | Evaporative light scattering device and methods of use thereof Apparatus for the detection of analytes in a fluid, for example the eluant from a liquid chromatography is described. Solvent is evaporated from the eluant to produce a stream of particles when analyte is present in the fluid. The resultant stream of particles is pa... | 12/07/2010 |
| 7872224 | Apparatus and method for positioning a discharge tube with respect to an orifice Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidabl... | 01/18/2011 |
| 7859657 | Methods of making and using an apparatus and devices for placing light and sample in photo-emitting or absorbing devices The present invention relates to apparatus and devices (11) for placing light with samples for analysis and method of making and using such apparatus and device. ... | 12/28/2010 |
| 7858932 | Capillary emitter for electrospray mass spectrometry Disclosed herein is an electrospray device for mass spectrometry that includes a fluid inlet, an outlet orifice, and a passage for fluid communication between the fluid inlet and outlet orifice. This passage is formed from a capillary (i.e., a first capillary). This... | 12/28/2010 |
| 7841190 | Freeze-thaw valve that self-limits cryogenic agent usage Methods and devices for the management of cryogenic agents within analytical systems using freeze thaw valving having an expansion chamber that limits the flow of the cryogenic agent. The expansion chamber is fitted with an expansion nozzle through which a cryogen f... | 11/30/2010 |
| 7800055 | System and method for grouping precursor and fragment ions using selected ion chromatograms LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After ... | 09/21/2010 |
| 7795570 | Self-scanned photodiode array with selectively-skipped pixels A self scanning photodiode array allows low signal pixels to accumulate charge for multiples of predetermined exposure time t0 before being read. The pattern of exposures, the integers Mi where I runs from 1 to N the number of pixels in the arr... | 09/14/2010 |
| 7754075 | Backflow prevention for high pressure gradient systems Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention ad... | 07/13/2010 |
| 7735878 | Self-setting high pressure fitting A coupling element (1) comprising a male sealing element (5) is disclosed herein. The male sealing element comprises a first end (7), second end (9), and a longitudinal axis extending between the first and second end. The coupling element... | 06/15/2010 |
| 7665480 | Defined lead path for high pressure seal Embodiments of the present invention are directed to methods and devices for conveying or containing fluids under pressure in which seals are provided with a defined path to vent fluid in the event of a seal failure. ... | 02/23/2010 |
| 7628920 | Compositions and methods for separating enantiomers A liquid chromatography system comprising a chiral mobile phase used to separate enantiomeric molecules present in a sample is disclosed herein. In one aspect, the mobile phase comprises a chiral solvent. In another aspect, the mobile phase includes a chiral solvent... | 12/08/2009 |
| 7607823 | Leak detector comprising a self-heated thermistor control circuit A system and method for detecting leaks includes a sensing circuit including a first thermistor device adapted to detected a leak upon contact with a liquid, and, a second thermistor device functioning as a reference device. The first and second thermistor devices a... | 10/27/2009 |
| 7596988 | High performance liquid chromatography sample introduction optimized with bubble detection A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a con... | 10/06/2009 |
| 7575676 | HPLC column holder apparatus An HPLC column holding apparatus used to mount an HPLC column in one of a plurality of positions is disclosed herein. The apparatus comprises a clip-device interface that secures the apparatus to a platform and a clip-column interface that secures the HPLC column to... | 08/18/2009 |
| 7504076 | Apparatus and methods for performing parallel processes Embodiments of the present invention are directed to an apparatus and method for performing parallel processes. One embodiment of the present invention is directed to an apparatus for performing a process having a plurality of steps in which each step is performed i... | 03/17/2009 |
| 7427752 | Mass spectrometer A magnetic sector mass spectrometer is disclosed comprising an ion detector (11) wherein a reflecting electrode (13) is used to divide an ion beam in the direction of mass dispersion into two separate ion beams. The two ion beams are directed onto two ... | 09/23/2008 |
| 7418352 | Method of using data binning in the analysis of chromatography/spectrometry data Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sa... | 08/26/2008 |
| 7417226 | Mass spectrometer An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the rea... | 08/26/2008 |
| 7405401 | Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry There is disclosed a method of selectively extracting ions comprising the steps of: providing a supply of ions in a body of gas; generating a ponderomotive ion trapping potential generally along an axis; generating further potentials to provide ... | 07/29/2008 |
| 7399410 | Chromatographic column and methods for controlling sorbent density Disclosed herein are apparatus and methods for mitigating column bed compression over time. This invention provides for an improved column design and method of controlling bed density in a chromatographic column using a protruding portion of a filter assembly. The i... | 07/15/2008 |
| 7396469 | Backflow prevention for high pressure gradient systems Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention ad... | 07/08/2008 |
| 7356995 | Peltier based freeze-thaw valves and methods of use A freeze-thaw valve is provided using a Peltier heat pump where the thermal short-circuit path between a cooled thermal mass and a heated thermal mass is reduced or absent and the valve state transition time is minimized. The freeze-thaw valve comprises a Peltier he... | 04/15/2008 |
| 7332087 | Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pu... | 02/19/2008 |
| 7311502 | Method for using a hydraulic amplifier pump in ultrahigh pressure liquid chromatography A method for supplying solvent to an ultra-high pressure liquid chromatography system using a hydraulic amplifier. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary ... | 12/25/2007 |
| 7309861 | Mass spectrometer A mass spectrometer is disclosed comprising a guide wire ion guide 1 having an outer cylindrical electrode 2 and an inner guide wire electrode 3. AC and DC potential differences are maintained between the outer electrode 2 and the inner e... | 12/18/2007 |
| 7308908 | Device and method for controlling the flow of fluid in a conduit The present invention provides devices and methods for controlling the flow of fluids in very high pressure situations. The devices feature valve shafts having bearings and pins to hold stator surfaces and rotor surfaces in proper alignment. ... | 12/18/2007 |
| 7251026 | Fluorescence detector geometry Excitation light of a selected wavelength from an excitation monochromator is directed along the long axis of a flow cell containing the sample to be analyzed, generating fluorescence. An emission monochromator is positioned at right angles to the plane of the excit... | 07/31/2007 |
| 7241115 | Methods and apparatus for determining the presence or absence of a fluid leak Embodiments of the present invention feature a method and apparatus for detecting defects, such as, leaks, component failure and adverse performance. One embodiment of the present apparatus for pumping fluid comprises a pumping chamber having an inlet and an outlet ... | 07/10/2007 |
| 7238937 | Substrate adapter for use in mass spectroscopy analysis Disclosed herein is a device for holding a substrate having one or more samples in a position for ionizing the samples with a light energy source. The device has a receiving plate with a receiving surface, a back surface and an edge defining an outline. One or more ... | 07/03/2007 |
| 7202473 | Mass spectrometer A mass spectrometer is disclosed wherein the experimentally determined mass to charge ratios of ions are reported together with an error band for each mass to charge ratio determination. The error band may, for example, reflect a 95% probability or confidence that t... | 04/10/2007 |
| 7192525 | Device for solid phase extraction and method for purifying samples prior to analysis A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent... | 03/20/2007 |
| 7189964 | System and method for isotopic signature and mass analysis Mass intensity values, isotopic ratios and exact mass differences between isotopes may be obtained and analyzed to determine if there are one or more masses of interest. In one implementation, a method will look among the mass intensity values for peaks of interest.... | 03/13/2007 |
| 7186336 | Flow sensing apparatus A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system. A first flow sensor is disposed in a first flow path between a first flow-divider and a fluidic tee. A second flow sensor is disposed... | 03/06/2007 |
| 7157697 | Ion detector An ion detector for a mass spectrometer is disclosed comprising one or more microchannel plates and an anode arranged to receive electrons emitted from the one or more microchannel plates. The anode preferably has a smaller diameter than the microchannel plates and ... | 01/02/2007 |
