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| Number | Title | Issue Date |
| 5981537 | Pyrimidine-thioalkyl and alkylether compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R4 is selected from the group consisting of --H or... | 11/09/1999 |
| 5965739 | Ɗ6,7 -taxols antineoplastic use and pharmaceutical compositions containing them This invention provides oxazolidine protected taxol analogs of the Formula: ##STR1## which are useful intermediates to make various taxol analogues.... | 10/12/1999 |
| 5922342 | Lateral edge coated controlled release pharmaceutical compositions The invention provides a controlled release composition comprising a compressed core containing a drug having two parallel planar surfaces (i.e. the top and bottom), and a seal coating surrounding the core except on said planar surfaces (i.e. on all later... | 07/13/1999 |
| 5821363 | Antineoplastic use and pharmaceutical compositions containing them This invention provides 7-deoxy-Ɗ12,13 -iso-taxol of formula (I) which are useful for the treatment of the same cancers for which taxol has been shown active. ##STR1##... | 10/13/1998 |
| 5776936 | Marcfortine/paraherquamide derivatives useful as antiparasitic agents There are disclosed 18-thiomarcfortine derivatives of the natural products marcfortine A, B and C, C-18 thioparaherquamide and derivatives thereof, novel N-1 marcfortines A, B, and C and derivatives thereof, novel N-1 paraherquamide and derivatives thereo... | 07/07/1998 |
| 5756458 | Stabilized potent GRF analogs Novel GRF PEPTIDES having Thr, Val or Ile at position 2, having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15, and optionally substituted with Val or Ile at position 19 are described. Compositions and the met... | 05/26/1998 |
| 5750533 | 14-substituted marcfortines and derivatives useful as antiparasitic agents There are disclosed 14-hydroxymarcfortine derivatives of the natural products marcfortine A, B, C, and D useful in the treatment and prevention of helminth and arthropod infections of animals and plants. The synthetic derivatives are of Formula (I)... | 05/12/1998 |
| 5739350 | CC-1065 analogs This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activi... | 04/14/1998 |
| 5703075 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones This invention relates to compounds of Formula I ##STR1## which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.... | 12/30/1997 |
| 5683717 | Gelatin coated medicament and process for making same This invention relates to coated medicaments and a process for providing spray coated gelatinous coverings for such medicaments. This invention is also directed to novel gelatinous compositions for spray coating tablets, caplets, pellets, granules and the... | 11/04/1997 |
| 5643942 | Methods, composition and solutions for treating alopecia This invention relates to the method for treating the form of alopecia commonly known as "male pattern baldness" which comprises regular topical application to the affected areas of the human scalp of a composition containing as at least one of its active... | 07/01/1997 |
| 5556878 | Ɗ6,7 -taxols antineoplatic use and pharmaceutical compositions containing them This invention provides 7-deoxy-Ɗ6,7 -taxol and 7-deoxy-Ɗ6,7 -taxol analogs of Formula I: ##STR1## The compounds of Formula I are useful for the same cancers for which taxol has been shown active, including human ovarian cance... | 09/17/1996 |
| 5541339 | CC-1065 analogs having two CPI subunits This invention concerns chemical compounds of general Formula I CPI1 -R5 -T-R'5 -CPI2 I The compounds of Formula I are useful as uv light absorbers, antibacterial agents, and are particularly useful as an... | 07/30/1996 |
| 5049561 | Anthelmintic acylhydrazones, method of use and compositions This invention concerns a process for killing internal parasites, especially nematodes, trematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effect... | 09/17/1991 |
| 5023334 | Anthelmintic pyridinyl acylhydrazones This invention concerns a process for killing internal parasites, especially nematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount o... | 06/11/1991 |
| 4978670 | Anthelmintic quaternaryalkyl acylhydrazones, method of use and compositions This invention concerns a process for killing internal parasites, especially nematodes, trematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effect... | 12/18/1990 |
| 4870082 | Anthelmintic quinolinyl acylhydrazones, method of use and compositions This invention concerns a process for killing internal parasites, especially nematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount o... | 09/26/1989 |
| 4820758 | Novel [5.5]-spiroketals This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 04/11/1989 |
| 4814347 | Anthelmintic spiroketals and method of use This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 03/21/1989 |
| 4812582 | Process for preparing aldol intermediates This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 03/14/1989 |
| 4795812 | 4-substituted-6-aryl-pyrimidine compounds This invention describes the synthesis and anti-neoplastic use of 4-aziridyl-5-substituted/unsubstituted 6-aryl-pyrimidine compounds of Formula IA ##STR1## as well as N'-[2-(1-aziridyl)ethyl]-6-aryl-2,4-pyrimidinediamines of Formula IB ##ST... | 01/03/1989 |
| 4698436 | Processes for the preparation of spectinomycin analogs, novel products and intermediates therein The present invention relates to novel methods of preparing a wide variety of spectinomycin analogs and biologically acceptable salts thereof. Further, the invention relates both to novel intermediates and novel products therein. The novel products are sp... | 10/06/1987 |
| 4686297 | Anthelmintic spiroketals useful for killing parasitic worms This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 08/11/1987 |
| 4680419 | Spiroketals and process for preparing same This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 07/14/1987 |
| 4631305 | Polymeric material as a disintegrant in a compressed tablet Compressed tablets containing polymeric material as a disintegrant. A particular material is colestipol hydrochloride.... | 12/23/1986 |
| 4613463 | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid This invention discloses an improved process for the production of corticoids from 17-hydroxy steroids utilizing peroxymonosulfate.... | 09/23/1986 |
| 4596812 | Methods and solutions for treating male pattern alopecia This invention relates to the method for treating the form of alopecia commonly known as "male pattern baldness" which comprises regular topical application to the affected areas of the human scalp of a composition containing as at least one of its active... | 06/24/1986 |
| 4588721 | Treatment of negative symptoms of schizophrenia Therapeutic process for treating the negative symptoms of schizophrenia in humans comprising the systematic administration of a compound of the formula ##STR1## X is a member selected from the group consisting of --H, --CH3, and --CH | 05/13/1986 |
| 4588529 | Mercury removal process Oxymercuration reaction products (I) and/or mercury contaminated steroids (I) are purified by dissolving the compound in a suitable solvent and contacting with a metal dust selected from zinc, copper or iron and a suitable acid.... | 05/13/1986 |
| 4554271 | Use of high doses of derivatives of 6-methylprednisolone for the acute treatment of stroke syndrome Use of water soluble 21-dibasic esters of 1-dehydro-6-methylhydrocortisone for the acute treatment of stroke syndrome in humans.... | 11/19/1985 |
| 4501695 | Spironalactone process The present invention relates to processes for the conversion of a 3-protected steroidal 17-ketone to a 17-spiro-γ-lactone having the appropriate 17-stereochemistry for spironolactone. Novel intermediates (II, II', II", II'", IIa, IIb | 02/26/1985 |
| 4481208 | Treatment of panic disorders with estazolam Therapeutic process for treating panic disorders in humans comprising, the systemic administration of a 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine including the N-oxides and pharmacologically acceptable acid addition salts thereof in c... | 11/06/1984 |
| 4477442 | Composition of matter and process A process for treating viral diseases in humans and animals which comprises administering a therapeutic amount of a compound of the formula ##STR1## the compounds are formulated with pharmaceutical carriers for systemic or local means of administrati... | 10/16/1984 |
| 4444781 | Process for inducing hypnosis Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 8-chloro-1-methanol-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiaz epine compound of the formula: ##STR1## Including the N-oxides and pharmacologi... | 04/24/1984 |
| 4443541 | Process for preparing an indenedione and a mycobacterium culture therefor A process for the microbiological conversion of steroids to (2+)-(7aS) 2,3,7,7-tetrahydro-7a-methyl-(1H)-indene-1,5(6H)-dione, hereinafter referred to as the indenedione.... | 04/17/1984 |
| 4423212 | Nucleosides and process Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.... | 12/27/1983 |
| 4357347 | Pesticidal phenylcarbamoylbenzimidates Phenylcarbamoylbenzimidates of the formula ##STR1## wherein X1 is selected from the group consisting of methyl, trifluoromethyl, chlorine, fluorine and bromine; X2 is selected from the group consisting of hydrogen, methyl, trifl... | 11/02/1982 |
| 4239753 | Composition of matter and process A process for treating DNA viral diseases in humans and animals which comprises administering a therapeutic amount of a compound of the formula ##STR1## the compounds are formulated with pharmaceutical carriers for systemic or local means of administ... | 12/16/1980 |
| 4196213 | Method of producing infertility in male rodents Pharmaceutical preparations in dosage forms and animal feeds (baits) consisting essentially of pharmaceutically acceptable carriers, oral and injectable, compounded with a sublethal, yet effective, amount of a compound having the formula: ##STR1## ... | 04/01/1980 |
| 4171431 | Nucleosides and process Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.... | 10/16/1979 |
