Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 4863941 | Glycerol derivatives Glycerol derivatives of the formula ##STR1## wherein one of the residues R1, R2 and R3 is a group U of the formula OY1 or --X1 --CO--(A1)n --Z1, another residue i... | 09/05/1989 |
| 4861772 | Method and composition to treat panic syndrome The known compound, t-butyl (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][ 1,4]benzodiazepine-1-carboxylate of the formula ##STR1## is effective in the prevention or interruption in a human being of panic states, accom... | 08/29/1989 |
| 4859665 | Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together ... | 08/22/1989 |
| 4855297 | Tricyclic pyridone derivatives The compounds of the formula ##STR1## wherein Ra,Rb,Rc Rd are defined in the specification and pharmaceutically acceptable addition salts are disclosed. The compounds of formula I have valuable pharmacological properties a... | 08/08/1989 |
| 4851519 | Pyrimidine derivatives Compounds of the formula ##STR1## wherein R1 is halogen, C1-4 -alkyl, halo-(C1-4 -alkyl) or C2-4 -alkanoyl, R2 is hydrogen, hydroxy, C1-4 alkoxy, C1-4 -alkylthio or phenyl-(... | 07/25/1989 |
| 4847273 | Dihydropyridine derivatives Dihydropyridine derivatives of the formula ##STR1## wherein the symbols R and R1 to R6 have the significance given in claim 1, have a pronounced calcium-antagonist activity and can accordingly be used as medicaments, especially ... | 07/11/1989 |
| 4826980 | Pyridazine intermediates Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ... | 05/02/1989 |
| 4814332 | Antimicrobial 1,3-disubstituted/imidazolium salts The imidazolium compounds of the formula ##STR1## wherein the various substituents are defined hereinbelow and their pharmaceutically acceptable acid addition salts, which possess valuable pharmacological properties are described. In particular, they... | 03/21/1989 |
| 4808631 | Aromatic acid derivatives Use of compounds of the formula ##STR1## wherein R1, R2, R3, R4 and R5, independently are hydrogen, alkyl, or C3-7 -cycloalkyl or two adjacent residues R1 to R5 t... | 02/28/1989 |
| 4808736 | Process for the preparation of hydroquinone derivatives and d--tocopherol In this process of the invention a compound of the formula ##STR1## wherein R is a leaving group, is reacted with a compound of the formula ##STR2## wherein R1 is an ether protecting group, and, if desired a thus-obtained compound of ... | 02/28/1989 |
| 4808727 | Imidazolium hydrogen carbonates The pharmaceutically acceptable salts corresponding to the imidazolium hydrogen carbonates of the formula ##STR1## wherein the symbol Q is arylene or heteroarylene, the group --NR1 R2 is a basic amino group, R3 is hyd... | 02/28/1989 |
| 4806541 | Quinoline derivatives Tetracyclic compounds of the formula ##STR1## wherein R1, R2, X, Y, Z and n are as herein described, and salts thereof, are described. The compounds of formula III have antibacterial activity, and are therefore useful as antibac... | 02/21/1989 |
| 4800206 | Pyridine-ethanolamine derivatives Pyridine-ethanolamines of the formula ##STR1## wherein n, X, Y, R1, R2 and R3 have the significances given in the description, their corresponding enantiomers, diastereomers, and racemates as well as the pysiologicall... | 01/24/1989 |
| 4788206 | Pentadieneamides Compounds of the formula ##STR1## Y is O ir S, *A is paraphenylene or *----(CH2)n----(X)m --(CH2)r ----, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0 to 3, s is an integer from 0 t... | 11/29/1988 |
| 4786646 | Cyclopropylpropenamides The invention relates to compounds of the formula ##STR1## Y is O or S, *A is paraphenylene or *--(CH2)n --(X)m --(CH2)r --, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0... | 11/22/1988 |
| 4785093 | Bicyclic compounds Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ... | 11/15/1988 |
| 4782176 | Phenoxycarboxylic acids Phenoxycarboxylic acids of the formula ##STR1## wherein R, R1, R2, R3, R4 R5, Z and n are as hereinafter set forth, are as described. The compounds of formula I are antagonists of slow reacting s... | 11/01/1988 |
| 4775756 | 5-(4-amino-3,5-dimethoxyphenyl)-5-hydroxy-barbituric acid The invention relates to substituted phenylbarbituric acids of the formula ##STR1## wherein R1 and R3, independently, are lower-alkoxy or lower-alkylthio; R2 is lower-alkoxy, hydroxy or amino; and R4 is hyd... | 10/04/1988 |
| 4775671 | Imidazodiazepines There is presented compounds of the formula ##STR1## wherein A together with the two carbon atoms denoted by and ଲ signifies one of the groups ##STR2## and the dotted line signifies the double bond present in cases (1), (2) an... | 10/04/1988 |
| 4735940 | Tricyclic pyridine derivatives and pharmaceutical compositions Compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt of a compound of formula I which has one or more basic substituents, are described. The compounds of formula I possess pronounced muscle relaxant, sedative-hypnotic... | 04/05/1988 |
| 4732902 | Pyrroloisoquinolinyl-dimethyloxoalkyl alkonoates and their use as antipsychotic agents The invention relates to long-acting depot producing antipsychotic pyrroloisoquinolinyl-dimethyloxoalkyl alkanoates of the formula ##STR1## wherein R1 and R2 independently, are hydrogen, alkyl of 1 to 4 carbon atoms, cycloalkyl ... | 03/22/1988 |
| 4731373 | Glycerin derivatives and inhibition of blood PAF Glycerine derivatives of the formula ##STR1## wherein the residues R1, R2 and R3 have the significance given in the description, and their hydrates, which inhibit blood platelet activating factor (PAF), are descried.... | 03/15/1988 |
| 4720546 | Intermediates for the preparation of substituted 2-phenyl-1,3-dioxolanes The compounds of the formula ##STR1## wherein one of the symbols Q and Q' is the group --CH.dbd. and the other is the group --CH.dbd. or --N.dbd., R1, R2 and R3 each independently are hydrogen or halogen and n is the ... | 01/19/1988 |
| 4692438 | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ... | 09/08/1987 |
| 4672066 | Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acids The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Y is alkylene; Z is alkylene, ##STR2## the asterisk herein denotes bonding to the substituted acetophenone; R2 is hydrogen or lower alkox... | 06/09/1987 |
| 4663462 | Substituted phenoxy-aminopropanol derivatives Phenoxy-aminopropanol derivatives of the formula ##STR1## wherein R is lower alkyl, X is oxygen or sulfur, n is the integer zero or 1, Y is methylene, ethylene or propylene or, when n is zero, Y can also be a group of the formula wherein the double-... | 05/05/1987 |
| 4650812 | 4-oxo-3,4-dihydro-2H-1-benzopyranyloxy alkanoic acid derivatives The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 is hy... | 03/17/1987 |
| 4650878 | 2-(2-oxo-1-pyrrolidinyl) acetic acids 2-(2-Oxo-1-pyrrolidinyl)acetic acids of the formula ##STR1## wherein R2 is hydrogen or lower alkyl and R11 is hydrogen, lower alkanoyl or another group readily cleavable by means of ammonia, are described. The compounds of formu... | 03/17/1987 |
| 4640918 | Substituted 2-phenyl-1,3-dioxolanes The compounds of the formula ##STR1## wherein one of the symbols Q and Q' is the group --CH.dbd. and the other is the group --CH.dbd. or --N.dbd., R1, R2 and R3 each independently are hydrogen or halogen and n is the ... | 02/03/1987 |
| 4632925 | N-substituted diphenylpiperidines and antiobesity use thereof Compounds of the formula ##STR1## wherein R1 is ##STR2## the asterisk denotes the specific bonding orientation to the piperidine moiety; R2 is alkylene or --CO--(CH2)n -- wherein n is 0 to 11; R | 12/30/1986 |
| 4632784 | Process for the preparation of 1,23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone The invention is directed to a process and intermediates for the preparation of 1, 23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone.... | 12/30/1986 |
| 4628115 | Substituted 4-acetyl-3-hydroxyphenoxy alkanoic acids The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Z is alkylene of 1 to 10 carbon atoms, --(C*H2)3 --C.tbd.C--, --C*H2 --C.tbd.C--(CH2)3 --, and --(... | 12/09/1986 |
| 4599416 | Process for the preparation of aqueous solutions of potentiated sulfonamides Aqueous solutions of antibacterially active sulfonamides and sulfonamide potentiators, which are suitable for parenteral administration and which contain no organic solvent, are prepared by reacting a sulfonamide RH with an aldehyde R1 CHO to g... | 07/08/1986 |
| 4595776 | Synthesis of 1,25-dihydroxyergocalciferol The invention is directed to a process and intermediates for the preparation of 1,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1,25-dihydroxyergocolciferol. The end-product 1,25-dihydroxyergocalciferol is u... | 06/17/1986 |
| 4594432 | Process for the synthesis of 1,23(S),25-trihydroxycholecalciferol and 1,23(R),25-trihydroxycholecalciferol The invention is directed to a process and intermediates for the preparation of 1,23(S),25-trihydroxycholecalciferol and 1,23(R),25-trihydroxycholecalciferol. The end-products, 1,23(S),25-trihydroxycholecalciferol and 1,23... | 06/10/1986 |
| 4594442 | Naphthalenyloxy substituted carboxylic acids Compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR2## wherein R1 is hydrogen, acyl or lower alkyl, R2 is hydrogen or lower alkyl, m is an integer ... | 06/10/1986 |
| 4591594 | Thromboxane synthase inhibitors as antiobesity agents The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are 1-substituted imidazoles, 4-substituted imidazoles, 3-substituted... | 05/27/1986 |
| 4587256 | Novel thiazolidine derivatives The invention relates to with novel thiazolidine derivatives of the formula ##STR1## wherein X is methylene, oxygen or sulfur; R1 is halogen; R2 is hydrogen, nitro, cyano, OR3 or NHR3 ; or R1 and R | 05/06/1986 |
| 4582641 | Compounds of o-(6-hydroxy-3-oxo-3H-thio(seleno)xanthen-9-yl)benzene sulfonic(benzoic) acid useful as photosensitizers Compounds of the formula ##STR1## wherein R1 -R4 is hydrogen or chlorine, R5 is --COOMe or --SO3 Me, Me is an alkali metal cation and X is oxygen, sulfur or selenium, photosensitizers for the conversion of ... | 04/15/1986 |
| 4581172 | Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension Pyrimidone derivatives of the formula ##STR1## wherein n is the integer 1 or 0; A1 and A2 are independently methylene or mono-lower alkyl or di-lower alkyl methylene; X is methylene, mono-lower alkyl or di-lower alkyl methylene,... | 04/08/1986 |
