...that after Walter Hunt patented the safety pin in 1849, he sold the rights to it for $400?
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| Number | Title | Issue Date |
| 8147880 | Polyacetylenic compounds for stimulating insulin gene exression, production and secretion This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2 | 04/03/2012 |
| 8137666 | Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence in Alzheimer's disease, prion diseases and/or other amyloidoses in a mammalian subject is disclosed. In the... | 03/20/2012 |
| 8101409 | Ultra-nanocrystalline diamond as a biomaterial for enhancing proliferation and differentiation of neural stem cells Compositions for promoting growth and/or differentiation of a stem cell are disclosed. The composition comprises: a) a diamond film; b) a stem cell cultured on the diamond film; and c) a medium bathing the stem cell. The stem cell may be a mammalian neural stem cell... | 01/24/2012 |
| 8093260 | Aporphine derivatives and pharmaceutical use thereof The present invention discloses novel aporphine derivatives. Also, the present invention discloses that these novel aporphine derivatives can be used for treating oxidative stress induced diseases such as cardiovascular disease, diabetes, aging, Alzheimer's disease,... | 01/10/2012 |
| 8062663 | Methods and compostions for enhancing transdermal drug delivery Methods and compositions for enhancing transdermal delivery of a bioactive agent. The method contains the step of applying to a skin tissue an effective amount of a composition comprising: (a) a drug vehicle; (b) a bioactive agent encapsulated within the drug vehicl... | 11/22/2011 |
| 8062632 | Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof A method for making hepatocytes from extrahepatic somatic stem cells comprises: a) culturing somatic stem cells in a medium comprising hepatic growth factor to cause the stem cells to differentiate toward hepatocytes; b) culturing cells from a) in a medium comprisin... | 11/22/2011 |
| 7989521 | Antifouling coating composition, antifouling coating film formed using the composition, coated article having the coating film on the surface, and antifouling treatment method to form the coating film An object of the present invention is to provide a composition for forming an environment friendly antifouling coating film that is unlikely to cause a hairline crack and like coating film defects even when immersed in seawater for a long time, and that prevents or ... | 08/02/2011 |
| 7977407 | Antifouling coating composition, antifouling coating film formed from the composition, coated object having the coating film on surface, and method of antifouling by forming the coating film An object of the present invention is to provide a composition for forming an environment friendly antifouling coating film that can effectively exhibit an antifouling effect in seawater for a long period of time and furthermore exhibits a small temperature dependen... | 07/12/2011 |
| 7955800 | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients Methods for determining a tumor in a human is disclosed. Also disclosed are methods for identifying adenocarcinoma, and methods for identifying squamous cell carcinoma in a human tumor sample. In addition, methods for predicting prognosis of metastasis and survival ... | 06/07/2011 |
| 7943739 | Methods for separating casein from soluble proteins in a composition A method for precipitating casein from a suspension comprising milk is disclosed. The method includes the following steps: adding a phosphate solution to a suspension; mixing the phosphate solution with the suspension to form a mixture having a phosphate concentrati... | 05/17/2011 |
| 7939567 | Dextromethorphan-based method for treating acne The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compoun... | 05/10/2011 |
| 7935684 | Method for treating allergic diseases The present invention relates to use of polysaccharides obtained from Dendrobium for treating an allergic disease or for reducing airway-remodeling caused by inflammation. ... | 05/03/2011 |
| 7931906 | Vero cell-based influenza virus strains and vaccines The present invention relates to isolated influenza virus strains suitable for increased vaccine production for mammals. The influenza virus strains contain at least one modified influenza protein that results in increased production of the influenza virus from a ma... | 04/26/2011 |
| 7803367 | Methods and compositions for promoting angiogenesis The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases. ... | 09/28/2010 |
| 7759461 | Expression system for enhancing solubility and immunogeneicity of recombinant proteins Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein comprising: (a) a first polypeptidyl fragment at the N-termina... | 07/20/2010 |
| 7695738 | Carbohydrate encapsulated nanoparticles The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in biologically important carbohydrate molecules, such as sugars, sugar deriv... | 04/13/2010 |
| 7671251 | In vivo assay for neurite outgrowth in zebrafish and its application in drug screening A genetically modified zebrafish embryo, comprising a HBNF cDNA or a NGF cDNA or a GDNF cDNA together with a cDNA encoding green fluorescent protein (GFP) so as to induce neurite outgrowth during said zebrafish embryonic development, and a method of using such genet... | 03/02/2010 |
| 7655779 | Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which ... | 02/02/2010 |
| 7655769 | Orthogonally protected disaccharide building blocks for synthesis of heparin Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and P4 are different, and ... | 02/02/2010 |
| 7635766 | Insulin-responsive DNA binding proteins-1 and methods to regulate insulin-responsive genes The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP-1 regulates genes impo... | 12/22/2009 |
| 7618635 | Super-antigen fusion proteins and the use thereof The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment for transporting a protein into a cell and translocating the protein i... | 11/17/2009 |
| 7595054 | Fusion antigen used as vaccine Fusion antigen used as vaccine. The invention relates to a fusion antigen specific for a target cell. The fusion antigen contains a ligand moiety, a Pseudomonas exotoxin A translocation domain II, an antigenic moiety, and a carboxyl terminal moiety. The ligan... | 09/29/2009 |
| 7582737 | Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharides Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharide. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and are different, and of them P1 i... | 09/01/2009 |
| 7563775 | Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP-1 regulates genes impo... | 07/21/2009 |
| 7524648 | Expression system for enhancing solubility and immunogeneicity of recombinant proteins Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein. The chimeric protein contains three polypeptidyl fragments: (... | 04/28/2009 |
| 7465455 | Fusion protein of porcine reproductive and respiratory syndrome virus as PRRS vaccine A fusion protein of porcine reproductive and respiratory syndrome virus (PRRSV) for PRRSV vaccine. The fusion protein includes: (a) a Pseudomoitas Exoloxin A (PE) peptide that comprises a binding domain and a translocating domain; (b) a peptide fragment that contain... | 12/16/2008 |