Hutchinson; Keith D. - US Patent Attorneys and Agents

Attorney: Hutchinson; Keith D.

Number of patents: 30
Last date: January 04, 2011

Browse patents
Browse applications

Number	Title	Issue Date
7863278	Isethionate salt of a selective CDK4 inhibitor Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell prol...	01/04/2011
7781583	Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), useful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof...	08/24/2010
7671043	Cycloalkylamino acid derivatives The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R...	03/02/2010
7642350	Purine derivatives This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I) whe...	01/05/2010
7622475	EP2 agonists The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering intraocular pressure and thereby treating glaucoma. ...	11/24/2009
7456168	2-(pyridin-2-ylamino)-pyrido[2,3, d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4). ...	11/25/2008
7449469	Prostaglandin derivatives Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. ...	11/11/2008
7332493	Substituted bicyclic derivatives for the treatment of abnormal cell growth The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m a...	02/19/2008
7273946	Prostaglandin derivatives Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. ...	09/25/2007
7230025	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to pr...	06/12/2007
7220772	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to pr...	05/22/2007
7217721	Tropane derivatives useful in therapy The present invention provides compounds of formula (I) wherein X, Y, R1, R2 and R3 are as defined hereinabove. The compounds of the present invention are modulators, espe...	05/15/2007
7217714	CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...	05/15/2007
7173059	Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed. ...	02/06/2007
7157468	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the descript...	01/02/2007
7141585	Pyrazole derivatives This invention relates to the use of pyrazole derivatives of the formula and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or modulator, to certain ...	11/28/2006
7109228	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their prepa...	09/19/2006
7101878	Non-peptide GNRH agents, methods and intermediates for their preparation Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorde...	09/05/2006
7041667	CCR5 modulators Compounds of Formula 1 [Region α]—[Region β]—[Region γ]—[Region δ] (1) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...	05/09/2006
6933312	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the description, a...	08/23/2005
6927217	HIV protease inhibitors The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development o...	08/09/2005
6903132	Non-peptide GnRH agents, pharmaceutical compositions and methods for their use Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and ster...	06/07/2005
6878727	Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus ...	04/12/2005
6855724	Tropane derivatives useful in therapy The present invention provides compounds of formula (I) wherein X, Y, R1, R2 and R3 are as defined hereinabove. The compounds of the present invention are modulators, especially...	02/15/2005
6852711	HIV protease inhibitors The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the...	02/08/2005
6833372	Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonad...	12/21/2004
6790612	Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene product. This system can be used to assess the activity of candidate pr...	09/14/2004
6750230	Pyrazole derivatives This invention relates to the use of pyrazole derivatives of the formula and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or modulator, to certain novel ...	06/15/2004
6750787	Optronic system for the measurement of vehicle traffic The present invention is a vehicle traffic measurement system designed to accurately count and record the number of vehicles passing through a selected location, to more accurately determine and record the velocity at which the individual vehicles travel through tha...	06/15/2004
6667314	Tropane derivatives useful in therapy The present invention provides compounds of the formula: ##STR1## wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, ...	12/23/2003

PatentStorm

Quotables

PatentStorm News

Attorney: Hutchinson; Keith D.