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| Number | Title | Issue Date |
| 8183286 | EP2 and EP4 agonists as agents for the treatment of influenza a viral infection The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof. ... | 05/22/2012 |
| 8173630 | Multipodal tethers for high-density attachment of redox-active moieties to substrates This invention provides redox-active molecules attached to polypodal (e.g., bipodal, tripodal, quadrapodal, pentapodal, etc.) tethers that can be used for attachment of the redox-active molecules to a substrate (e.g., an electrode). The tethered redox-active molecul... | 05/08/2012 |
| 8158586 | Inhibitors of protein kinases and uses thereof Compounds that are capable of inhibiting the activity of one or more protein kinases are provided. The compounds are short, predominantly basic peptidic compounds comprising between about 5 and about 20 amino acids, and can optionally comprise an ATP mimetic moiety.... | 04/17/2012 |
| 8158207 | Durable modification of the wetting properties of a surface This invention provides compositions and methods to durably increase or decrease the wetting properties of a surface. In certain embodiments the methods utilize a polyquaternary ammonium compound to decrease wettability of the surface or a cationic polysaccharide to... | 04/17/2012 |
| 8148328 | Salicylanilides enhance oral delivery of therapeutic peptides This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significa... | 04/03/2012 |
| 8115096 | Methods and apparatuses for improving power extraction from solar cells The field of the invention relates to minimization of resistive loss of solar panels in order to achieve maximum solar energy conversion efficiency, extracting more electricity power from available solar irradiance. Schemes are designed to take advantage of the geom... | 02/14/2012 |
| 8066971 | Targeting pulmonary epithelium using ADRP This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The compositions comprise an adipocyte differentiation-related protein (AD... | 11/29/2011 |
| 8062756 | Stepwise growth of oligomeric redox-active molecules on a surface without the use of protecting groups This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no... | 11/22/2011 |
| 8048851 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 11/01/2011 |
| 7994132 | Peptides for treatment of scleroderma Peptides are provided that ameliorate one or more symptoms of scleroderma. In various embodiments, the peptides range in length from about 10 to about 30 amino acids, comprise a class A amphipathic helix, and bear at least one protecting group. The peptides are high... | 08/09/2011 |
| 7927871 | Visualization and quantitation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that apoptosis pathway activation and, in particular, granzyme B activity... | 04/19/2011 |
| 7902258 | Methods for preventing lesions caused by viruses of the Herpesviridae or Poxviridae family A method for preventing lesions caused by a virus of the Herpesviridae or Poxviridae family, comprising topically applying a composition consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH o... | 03/08/2011 |
| 7879936 | Protective masking solutions comprising thixotropic film formers This invention provides a masking material that can be used to protect an underling surface (e.g., an automobile surface) during an overcoating (e.g., painting) operation. The masking material in one embodiment includes a thickener and a pH control agent and water. ... | 02/01/2011 |
| 7879574 | Compositions for the detection of enzyme activity in biological samples and methods of use thereof The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated to two fluorophores such that the fluorophores are located opposite ... | 02/01/2011 |
| 7868138 | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding m... | 01/11/2011 |
| 7795397 | Red and near infrared flourescent phyotochrome This invention provides fluorescent adducts that emit in the far red and/or near infrared. In certain embodiments, the adducts comprise a mutant apoprotein and a bilin. ... | 09/14/2010 |
| 7723303 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 05/25/2010 |
| 7723045 | Assays to predict atherosclerosis and dysfunctional high-density lipoprotein This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurement... | 05/25/2010 |
| 7670599 | YKL-40 as a marker and prognostic indicator for cancers This invention provides methods for detecting cancers and for evaluating the prognosis of cancer patients. In particular, the methods of this invention utilize YKL-40 as a marker for the presence or absence of a cancer and for the prognosis (e.g. likelihood of recur... | 03/02/2010 |
| 7638494 | G-type peptides to ameliorate atherosclerosis This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The peptides a... | 12/29/2009 |
| 7605128 | Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia This invention pertains to the identification of neurogenerative and/or neurotrophic factors that can induce migration of stem cells to neural tissue and/or induce proliferation and/or differentiation of such cells into neurons. Such agents include, but are not limi... | 10/20/2009 |
| 7582736 | Prostate cancer specific internalizing human antibodies This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an e... | 09/01/2009 |
| 7579319 | Methods for improving the structure and function of arterioles The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a metho... | 08/25/2009 |
| 7544177 | Aerosol device to deliver bioactive agent This invention provides surgical devices and methods to apply bioactive agents to surgical sites. The devices include, e.g., a body for attachment of a pressurized fluid vessel and a reservoir of bioactive agent for controlled spraying of an aerosol of bioactive age... | 06/09/2009 |
| 7541143 | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid, polypeptide, etc.) joining two fluorophores of the same species whereby the flu... | 06/02/2009 |
| 7531514 | Orally administered peptides synergize statin activity This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptides comprise an 18 amino acid class A amphipathic helix with protecting groups on the amino and the carboxyl terminus. The peptides are h... | 05/12/2009 |
| 7518905 | High density memory device This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 1015 bits/cm3), that provide a high degree of fault tolerance, and t... | 04/14/2009 |
| 7499166 | Wide field imager for quantitative analysis of microarrays This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges... | 03/03/2009 |
| 7452572 | Procedure for preparing redox-active polymers on surfaces This invention provides novel methods for the formation of redox-active polymers attached to surfaces. In certain embodiments, the methods involve providing redox-active molecules bearing at least a first reactive site or group and a second reactive site or group; a... | 11/18/2008 |
| 7402286 | Capillary pins for high-efficiency microarray printing device This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention... | 07/22/2008 |
| 7399790 | Virucidal compositions A method of inactivating enveloped virus comprises contacting said virus with a virucidally effective amount of a composition comprising a C1 to C3 monohydroxy alcohol or a C3 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below... | 07/15/2008 |
| 7388088 | High affinity human antibodies to tumor antigens This invention provides for novel human antibodies that specifically bind to c-erbB-2. The antibodies may be used alone or as components of chimeric molecules that specifically target and deliver effector molecules to cells overexpressing c-erbB-2. ... | 06/17/2008 |
| 7365047 | Use of pentagastrin to inhibit gastric acid secretion or as a diuretic This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy of the PPI in reducing/mitigating excess gastric acid secretion. ... | 04/29/2008 |
| 7348206 | Formation of self-assembled monolayers of redox SAMs on silicon for molecular memory applications This invention provides a new method of forming a self-assembling monolayer (SAM) of alcohol-terminated or thiol-terminated organic molecules (e.g. ferrocenes, porphyrins, etc.) on a silicon or other group IV element surface. The assembly is based on the formation o... | 03/25/2008 |
| 7335744 | Prostate cancer specific internalizing human antibodies This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an e... | 02/26/2008 |
| 7332580 | Bispecific single chain Fv antibody molecules and methods of use thereof Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family. ... | 02/19/2008 |
| 7332585 | Bispecific single chain Fv antibody molecules and methods of use thereof Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family. ... | 02/19/2008 |
| 7312100 | In situ patterning of electrolyte for molecular information storage devices This invention pertains to methods assembly of organic molecules and electrolytes in hybrid electronic. In one embodiment, a method is provided that involves contacting a surface/electrode with a compound of formula: R-L2-M-L1-Z1 whe... | 12/25/2007 |
| 7312068 | Capillary pins for high-efficiency microarray printing device This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention... | 12/25/2007 |
| 7312302 | Compositions for the detection of enzyme activity in biological samples and methods of use thereof The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated to two fluorophores such that the fluorophores are located opposite ... | 12/25/2007 |
