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| Number | Title | Issue Date |
| 8178096 | Use of an anti-CD151 antibody in the treatment of cancer The present invention relates to the use of at least one antibody, or a functional fragment thereof, which is capable of binding to the CD151 protein and thereby inhibiting tumor growth, in the preparation of a medicament intended for the treatment of cancer. | 05/15/2012 |
| 8173644 | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to ... | 05/08/2012 |
| 8148552 | Process for the synthesis of anticancer (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-c... | 04/03/2012 |
| 8143449 | Process for the synthesis of agomelatine Process for the industrial synthesis of the compound of formula (I) ... | 03/27/2012 |
| 8138375 | Method for producing 1-formamido-3,5-dimethyladamantane The invention relates to a method for producing 1-formamido-3,5-dimethyladamantane in only two reaction steps by direct formamide formation of 1,3-dimethyladamantane, the 1,3-dimethyladamantane being reacted with formamide in concentrated acids. ... | 03/20/2012 |
| 8138223 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): M... | 03/20/2012 |
| 8133889 | Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, ... | 03/13/2012 |
| 8119835 | Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suz... | 02/21/2012 |
| 8119794 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid. ... | 02/21/2012 |
| 8110701 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the preparation of compounds of formula (IV): wherein R1, R2, R3 and R4, which may be identical or different, each represent a hydrogen atom, a linear or branched (C | 02/07/2012 |
| 8106102 | Process for the preparation and conversion of synthesis gas A process (10) for the preparation and conversion of synthesis gas includes reforming a feed gas (34) comprising methane in a reforming stage (18) to produce synthesis gas (46) which includes hydrogen and carbon monoxide. Some of the hydr... | 01/31/2012 |
| 8101747 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid. ... | 01/24/2012 |
| 8097720 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid. ... | 01/17/2012 |
| 8087775 | Hinge arrangement for spectacles A hinge arrangement is described in which a pair of temples (1) are connected to a frontal portion (10) of the frame by a connection of upper and lower jaws (15, 16) extending from the frontal portion and passing through one or two apertures ( | 01/03/2012 |
| 8076325 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R | 12/13/2011 |
| 8067639 | Crystalline form VI of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form VI of the compound of formula (I): characterised by its X-ray powder diffraction diagram. Medicinal products containing the same which are useful in treating melatoninergic disorders. ... | 11/29/2011 |
| 8063100 | Process for the synthesis of strontium ranelate and its hydrates A process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates. ... | 11/22/2011 |
| 8008337 | Azabicyclo[3.2.0] hept-3-yl compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group ... | 08/30/2011 |
| 8003682 | Indole compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 represents a linear or branched (C1-C | 08/23/2011 |
| 7999129 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine. ... | 08/16/2011 |
| 7999009 | Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them Strontium salts of the sulphonic acids of formula (I): A-B—SO3H (I), wherein: A represents a group selected from OH, NH2, SO3H and CO2H,... | 08/16/2011 |
| 7994359 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine. ... | 08/09/2011 |
| 7985753 | Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 | 07/26/2011 |
| 7982054 | Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine. ... | 07/19/2011 |
| 7981920 | Addition salts of angiotensin-converting enzyme inhibitors with no donor acids, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): (A)m·(B)n (I) wherein A represents an angiotensin-converting enzyme inhibitor compound containing at least one salt-forming basic function, B represents a compound containing at least one salt... | 07/19/2011 |
| 7964199 | Therapeutic composition comprising a botulinum neurotoxin A pharmaceutical preparation comprising one of the botulinum neurotoxins from Clostridium botulinum of types A, B, C, D, E, F or G or a mixture of two or more of these neurotoxins, wherein the neurotoxin or the mixture of neurotoxins is free of the complexing... | 06/21/2011 |
| 7960438 | Use of agomelatine in obtaining medicaments intended for the treatment of generalized anxiety disorder The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in obtaining medicaments intended for the treatment of Generalized Anxiety Disorder. ... | 06/14/2011 |
| 7947852 | Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a gro... | 05/24/2011 |
| 7947743 | Use of agomelatine in obtaining medicaments intended for the treatment of bipolar disorders The present invention relates to the use of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, on its own or in association, in obtaining medicaments intended for the treatment of bipolar disorders, especially bipolar disorders of types I and II, and more e... | 05/24/2011 |
| 7947689 | Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least on... | 05/24/2011 |
| 7939566 | Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form III of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders. ... | 05/10/2011 |
| 7928223 | Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. ... | 04/19/2011 |
| 7927836 | Device and method for the production of biologically active compounds by fermentation The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is located within a working chamber or is adjacent to it. A pressure gradie... | 04/19/2011 |
| 7927813 | Peptides which interact with anti-apoptotic members of the Bcl-2 protein family, and uses The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with ... | 04/19/2011 |
| 7923569 | β Crystalline form of the arginine salt of perindopril, a process for its preparation and pharmaceutical compositions containing it β-crystalline form of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme. | 04/12/2011 |
| 7919233 | Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluoresce... | 04/05/2011 |
| 7910625 | Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form IV of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders. ... | 03/22/2011 |
| 7906547 | Azabicylic compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group selected from | 03/15/2011 |
| 7902377 | Method for preparing medetomidine and its salts The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagen... | 03/08/2011 |
| 7902180 | Association between agomelatine and a thymoregulatory agent and pharmaceutical compositions containing it Association comprising agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, in association with a thymoregulatory agent. Medicinal products containing the same which are useful in the treatment of mood disorders. ... | 03/08/2011 |
