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| Number | Title | Issue Date |
| 8143264 | Xanthine derivatives as selective HM74A agonists The present invention relates to a xanthine compound derivative which is 3-butyl-8-chloro-1-(3-{5-[(4-fluorophenyl)methyl]-2H-tetrazol-2-yl}propyl)-3,7-dihydro-1H-purine-2,6-dione: a pharmaceutically acceptable salt thereof... | 03/27/2012 |
| 8076475 | Process The present invention generally relates to a novel process for preparing vitronectin receptor antagonist compounds having a benzodiazepinyl core structure. This invention relates to the preparation of pharmaceutically active compounds which inhibit the vitronectin r... | 12/13/2011 |
| 7982053 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 07/19/2011 |
| 7902378 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen... | 03/08/2011 |
| 7893100 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen... | 02/22/2011 |
| 7893056 | Peptide deformylase inhibitors The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and i... | 02/22/2011 |
| 7759384 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen... | 07/20/2010 |
| 7713982 | Xanthines with HM74A receptor activity The present invention relates to a therapeutically active xanthine derivative compound of formula (I): corresponding pharmaceutical formulations containing, manufacture processes for, methods or uses of such compounds in th... | 05/11/2010 |
| 7649010 | Carvedilol hydrobromide The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in pa... | 01/19/2010 |
| 7626041 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen... | 12/01/2009 |
| 7601729 | Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein: A represents bond, C1-6alkyl or CH═CH—C1-4alkyl; B represents bond, O, S, SO, SO2, CO, CR7R8, CO2 | 10/13/2009 |
| 7476759 | Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein: R1 is optionally substituted —C4-12 alkyl, —C2-10alkylcycloalkyl, —C2-6alkylheterocycloalkyl, ... | 01/13/2009 |
| 7452906 | Pyridine derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/18/2008 |
| 7446106 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/04/2008 |
| 7375105 | Pyridine substituted furan derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R | 05/20/2008 |
| 7375248 | Inhibitors of matrix metalloproteinase Compounds of formula (I): wherein R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or hete... | 05/20/2008 |
| 7297693 | Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7297694 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7288564 | Indole derivatives Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a... | 10/30/2007 |
| 7282500 | Imidazole-2-carboxamide derivatives as Raf kinase inhibitors The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotrau... | 10/16/2007 |
| 7268156 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen ... | 09/11/2007 |
| 7250439 | Matrix metalloproteinase inhibitors Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR5 or CR... | 07/31/2007 |
| 7235658 | Imidazol derivatives as Raf kinase inhibitors Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is ... | 06/26/2007 |
| 7199137 | Imidazole derivatives as Raf kinase inhibitors Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b). ... | 04/03/2007 |
| 7173047 | Benzo (f) insoindol derivatives and their use as ep4 receptor ligands Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, i... | 02/06/2007 |
| 6989447 | Compounds Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 01/24/2006 |
| 6987119 | Imidazol-2-carboxamide derivatives as raf kinase inhibitors Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6 | 01/17/2006 |
| 6987115 | Antibacterial compounds Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het; R2 is C1-6a... | 01/17/2006 |
| 6962917 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 11/08/2005 |
| 6924297 | Naphathalene derivatives which bind to the EP4 receptor Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunol... | 08/02/2005 |
| 6911442 | Quinoline derivatives as antibacterials The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or N-oxide thereof: corresponding novel medicaments, pharmaceutical compositions and/or methods of ... | 06/28/2005 |
| 6881736 | Vitronectin receptor antagonists Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: wherein R1 is Het or Ar ... | 04/19/2005 |
| 6825188 | Vitronectin receptor antagonists Compounds having a benzodiazepinyl core structure are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis, angiogenesis, tumor growth and metastasis, atherosclerosis, restenosis and inflammation. ... | 11/30/2004 |
