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| Number | Title | Issue Date |
| 6451810 | Amide substituted imidazoquinolines Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are ... | 09/17/2002 |
| 6437131 | Process for preparing imidazoquinolinamines A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof... | 08/20/2002 |
| 6376669 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 04/23/2002 |
| 6365166 | Gel formulations for topical drug delivery Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug 4-amino-2-ethoxymethyl-,-di... | 04/02/2002 |
| 6348462 | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 02/19/2002 |
| 6331539 | Sulfonamide and sulfamide substituted imidazoquinolines Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of vario... | 12/18/2001 |
| 6323200 | Oxazolo, thiazolo and selenazolo [4,5-c] quinolin-4-amines and analogs thereof Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and... | 11/27/2001 |
| 6312715 | Adhesive microsphere drug delivery composition Transdermal drug delivery compositions comprising pressure sensitive adhesive microspheres that contain a softening agent and/or a drug. Typically the microspheres contain at least 10 wt-% of a softening agent. The drug and/or softening agent can be incor... | 11/06/2001 |
| 6193996 | Device for the transdermal delivery of diclofenac The present invention provides a pressure sensitive skin adhesive comprising: (a) a copolymer of one or more alkyl(meth)acrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers; (b) a mixture of penetration enhancers co... | 02/27/2001 |
| 6194425 | Imidazonaphthyridines Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermedi... | 02/27/2001 |
| 6150523 | Process for preparing imidazoquinolinamines A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.... | 11/21/2000 |
| 6136807 | Composition for the transdermal delivery of lerisetron The present invention provides a transdermal drug delivery composition comprising: (a) a copolymer of one or more (meth)acrylate monomers being selected from the group consisting of alkyl acrylates containing 4 to 12 carbon atoms in the alkyl group and al... | 10/24/2000 |
| 6132760 | Transdermal device for the delivery of testosterone A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.... | 10/17/2000 |
| 6121323 | Bishydroxyureas Bishydroxyureas are provided that inhibit the enzyme 5-lipoxygenase. These compounds have the formula I ##STR1## wherein R1, R2, R3, R4, A and M are defined herein. Also disclosed are pharmaceutical composi... | 09/19/2000 |
| 6113008 | Actuator system for spraying a formulation onto a host Actuator system is used to dispense a defined volume of a formulation from a pressurized vial. The system houses the vial in a receptacle of a base section that also includes a dispensing section (e.g., a funnel) through which the formulation is sprayed. ... | 09/05/2000 |
| 6110929 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and... | 08/29/2000 |
| 6086911 | Drug delivery device Optically pure S(+) flurbiprofen, which is substantially free of the R(-) enantiomer, is a potent analgesic for relieving pain and inflammation in humans and animals. A method and composition is disclosed utilizing the optically pure S(+) enantiomer of fl... | 07/11/2000 |
| 5998619 | Process for preparing imidazoquinolinamines A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.... | 12/07/1999 |
| 5977366 | 1-substituted, 2-substituted 1H-imidazo[4,5-c] quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 11/02/1999 |
| 5939090 | Gel formulations for topical drug delivery Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug 4-amino-2-ethoxymethyl-,-di... | 08/17/1999 |
