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| Number | Title | Issue Date |
| 8153683 | Methods of treatment using a prodrug of an excitatory amino acid This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 04/10/2012 |
| 8148387 | AKT and P70 S6 kinase inhibitors The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of ... | 04/03/2012 |
| 8093383 | P70 S6 kinase inhibitors The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use. ... | 01/10/2012 |
| 8093244 | Heteroaryl urea derivatives useful for inhibiting CHK1 Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases ... | 01/10/2012 |
| 7998977 | Inhibitors of AKT (protein kinase B) 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds... | 08/16/2011 |
| 7981892 | Disubstituted phthalazine hedgehog pathway antagonists The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer. ... | 07/19/2011 |
| 7964632 | Methods of treatment using a prodrug of an excitatory amino acid This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 06/21/2011 |
| 7872020 | TGF-β inhibitors The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihydro -4H-pyrrolo[1,2-b]pyrazole monohydrate. ... | 01/18/2011 |
| 7855211 | Protein kinase inhibitors The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases. ... | 12/21/2010 |
| 7834029 | Quinolinyl-pyrrolopyrazoles A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound. ... | 11/16/2010 |
| 7671082 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 03/02/2010 |
| 7612067 | Imidazopyridazine compounds The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric diso... | 11/03/2009 |
| 7608618 | Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of | 10/27/2009 |
| 7560462 | Compounds useful for inhibiting CHK1 Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, ... | 07/14/2009 |
| 7557103 | Imidazopyridazine compounds The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I) pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disor... | 07/07/2009 |
| 7511065 | Mixed lineage kinase modulators The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient,... | 03/31/2009 |
| 7511056 | TGF-β inhibitors The present invention is directed to inhibitors of TGF-β of Formula I: ... | 03/31/2009 |
| 7456221 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 11/25/2008 |
| 7449477 | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections. ... | 11/11/2008 |
| 7414063 | Inhibitors of Akt (protein kinase B) The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections. ... | 08/19/2008 |
| 7405299 | Compounds as pharmaceutical agents The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said c... | 07/29/2008 |
| 7378447 | Muscarinic agonists The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor ... | 05/27/2008 |
| 7371872 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 05/13/2008 |
| 7368445 | Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds. ... | 05/06/2008 |
| 7265246 | Indane derivates as muscarinic receptor agonists The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor ... | 09/04/2007 |
| 7265225 | Quinolinyl-pyrrolopyrazoles A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound. ... | 09/04/2007 |
| 7256217 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs according to formula (I) and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurolo... | 08/14/2007 |
| 7204981 | Methods of treating diseases with activated protein C Method of treating a disease or pathological condition with activated protein C or a compound having activated protein C activity by direct regulation of the expression of specific genes associated with the disease or pathological condition. ... | 04/17/2007 |
| 7160922 | Hemihydrate of a selective functional M1 muscarine receptor agonist The present invention provides crystalline biphenyl-4-carboxylic acid (R)-(6-(1-((4-fluorobenzyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide hemihydrate, compositions thereof, methods of using the same, processes for making the same, and processes for ... | 01/09/2007 |
| 7144898 | Indole derivatives for the treatment of depression and anxiety The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. | 12/05/2006 |
| 7135487 | Sulphonamide derivatives The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. ... | 11/14/2006 |
| 7087578 | Formulations and methods for treating hypercoagulable states A method of treating a human patient with a hypercoagulable state or protein C deficiency, which comprises administering activated Protein C and protein C Zymogen. ... | 08/08/2006 |
| 7034045 | Monofluoroalkyl derivatives The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 04/25/2006 |
| 6984756 | Process for preparing biphenyl compounds The present invention relates to a process for the preparation of a biphenyl compound comprising combining a phenyl boronic acid derivative with an halobenzene derivative in the presence of a suitable additive in a suitable organic solvent with a suitable catalyst a... | 01/10/2006 |
| 6900353 | Cyclopentyl sulfonamide derivatives The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 05/31/2005 |
| 6815533 | Cryogranulation of activated protein C The present invention is directed at a method of processing an aqueous solution of protein C into a state suitable for storage, handling, and recovery. The present invention provides aqueous activated protein C solutions and an improved method of processing such sol... | 11/09/2004 |
| 6767539 | Method of treating viral hemorrhagic fever The present invention provides a method of treatment of viral hemorrhagic fever with protein C. The claimed invention provides a needed therapy for a serious and debilitating disorder while avoiding complications such as bleeding tendency, toxicity and general side ... | 07/27/2004 |
| 6743426 | Method of treating heparin-induced thrombocytopenia The present invention provides a method of treatment of heparin-induced thrombocytopenia (HIT) with protein C. The claimed invention provides a needed therapy for a potentially serious and debilitating disorder while avoiding complications such as bleeding tendency,... | 06/01/2004 |
