Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7229983 | 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid derivatives as β-lactamase inhibitors The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which ... | 06/12/2007 |
| 7105531 | Tricyclic protein kinase inhibitors This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents. ... | 09/12/2006 |
| 6960686 | Preparation and purification of antiviral disulfonic acid disodium salt The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptab... | 11/01/2005 |
| 6812227 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors Compounds of the formula: are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerati... | 11/02/2004 |
| 6806366 | Preparation and purification of antiviral disulfonic acid disodium salt The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptab... | 10/19/2004 |
| 6762178 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and de... | 07/13/2004 |
| 6753337 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. ... | 06/22/2004 |
| 6716833 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors Compounds of the formula: are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative... | 04/06/2004 |
| 6638929 | Tricyclic protein kinase inhibitors This invention provides compounds of formula 1, having the structure ##STR1## which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.... | 10/28/2003 |
| 6544984 | 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids Compounds having the following formula: ##STR1## are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.... | 04/08/2003 |
| 6465508 | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.... | 10/15/2002 |
| 6432979 | Method of treating or inhibiting colonic polyps and colorectal cancer This invention provides a method of treating or inhibiting colonic polyps or treating or inhibiting colorectal cancer in a mammal in need thereof which comprises administering to said mammal an NSAID and an EFGR kinase inhibitor.... | 08/13/2002 |
| 6395726 | 3,6-disubstituted penam sulfone derivatives Compounds are provided having the following formulae I and II: ##STR1## wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group;... | 05/28/2002 |
| 6384051 | Method of treating or inhibiting colonic polyps This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula 1 ##STR1## wherein: R1, R2, R3, R4, X, Y, and n are as defined hereinbefore, or a pharmac... | 05/07/2002 |
| 6384223 | Substituted quinazoline derivatives This invention provides a process for preparing compounds of formula 1: ##STR1## wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms... | 05/07/2002 |
| 6380243 | Aminopyridine-containing thiourea inhibitors of herpes viruses Compounds of the formula ##STR1## wherein A is heteroaryl; R9 -R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and ... | 04/30/2002 |
| 6358980 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors Compounds of the formula: ##STR1## useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.... | 03/19/2002 |
| 6355636 | Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases This invention provides compounds of formula I having the structure ##STR1## useful as inhibitors of protein tyrosine kinase.... | 03/12/2002 |
| 6342508 | N-hydroxy-2-(Alkyl,Aryl or Heteroaryl sulfanyl, sulfinyl or sulfonyl) 3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMps) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/29/2002 |
| 6340691 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.... | 01/22/2002 |
| 6335350 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses Compounds of the formula: ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi he... | 01/01/2002 |
| 6331563 | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl, Sulfanyl, Sulfinyl or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 12/18/2001 |
| 6326516 | Acetylenic ଲ-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors The invention discloses hydroxamide acids of the formula: ##STR1## which are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease... | 12/04/2001 |
| 6323209 | Method of treating or inhibiting colonic polyps This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted; R and R1 | 11/27/2001 |
| 6313123 | Acetylenic sulfonamide thiol tace inhibitors The compounds of formula B: ##STR1## which are useful in disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss... | 11/06/2001 |
| 6297258 | Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as... | 10/02/2001 |
| 6288082 | Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as... | 09/11/2001 |
| 6288086 | N-hydroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 09/11/2001 |
| 6277885 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage ... | 08/21/2001 |
| 6271236 | Diaminopyridine-containing thiourea inhibitors of herpes virus Compounds of the formula ##STR1## wherein R1 -R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl ... | 08/07/2001 |
| 6262082 | Diaminopyridine-containing thiourea inhibitors of herpes viruses Compounds of the formula ##STR1## wherein R1 -R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl ... | 07/17/2001 |
| 6255349 | Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group Compounds having the formula: ##STR1## wherein R1 -R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycl... | 07/03/2001 |
| 6251912 | Substituted quinazoline derivatives This invention provides compounds of formula 1 having the structure ##STR1## wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents an... | 06/26/2001 |
| 6127317 | Concentrated, aqueous herbicidal compositions containing an imidazolinyl acid salt and a glyphosate salt The present invention provides concentrated aqueous herbicidal compositions of imidazolinyl acid salts and glyphosate salts.... | 10/03/2000 |
| 6121203 | Method for the control of goatgrasses There is provided a method for the control of an Aegylops plant which comprises applying to said plant or the locus in which it is growing or to be grown a herbicidally effective amount of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-(methoxymethyl)... | 09/19/2000 |
| 6114535 | Process and intermediates for the manufacture of pyridine-2,3-dicarboxylate compounds The present invention provides a process to prepare a pyridine-2,3-dicarboxylate derivative via the reaction of a dialkyl alkoxy(or alkylthio)oxalacetate with an appropriately substituted acrolein compound in the presence of an ammonia source and a solven... | 09/05/2000 |
| 6093682 | Solid agricultural composition comprising a monosaccharide, an oligosaccharide and/or a polysaccharide The present invention provides solid agricultural compositions which produce stable dispersions in the presence of polyacrylamide drift control agents. The present invention also provides stable, aqueous dispersions which are produced from the solid compo... | 07/25/2000 |
| 6080867 | Process and intermediates for the manufacture of pyridine-2,3-dicarboxylate compounds The present invention provides a process to prepare a pyridine-2,3-dicarboxylate derivative via the reaction of a dialkyl alkoxy(or alkylthio)oxalacetate with an appropriately substituted acrolein compound in the presence of an ammonia source and a solven... | 06/27/2000 |
| 6077863 | 2-aryl-4-halo-5-(trifluoromethyl)pyrrole-3-carbonitriles for the protection of wood, wood products and wooden structures from insect attack The present invention provides a method for the protection of wood, wood products and wooden structures from wood-eating insect attack and infestation which comprises treating said wood, wood product or wooden structure or the soil surrounding said wood, ... | 06/20/2000 |
| 6071951 | Arylpyrroles for subterranean termite control The present invention provides a method for the control of subterranean termite populations which comprises applying to the soil a termiticidally effective amount of an arylpyrrole compound of formula I. ##STR1##... | 06/06/2000 |
