Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7049440 | Enantioselective process An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed. ... | 05/23/2006 |
| 6979463 | Stable extended release oral dosage composition A film-coated extended release solid oral dosage composition containing a nasal decongestant, pseudoephedrine or salt thereof, e.g., pseudoephedrine sulfate in a core effective to provide a geometric maximum plasma concentration of pseudoephedrine of about 345 ng/mL... | 12/27/2005 |
| 6924270 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the treatment of susceptible viral infections, for example, chronic hepatitis C i... | 08/02/2005 |
| 6849254 | HCV combination therapy Methods of treating patients having susceptible viral infections, especially chronic hepatitis C infection by administering to said patient a therapeutically effective amount of a combination therapy of interferon-alfa and ribavirin for a time sufficient to lower HC... | 02/01/2005 |
| 6824768 | Ribavirin-pegylated interferon alfa induction HCV combination therapy There is disclosed a method for treating antiviral treatment naives patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using (1) a therapeutically effective inducing amount of ribavirin and a therapeutically ... | 11/30/2004 |
| 6723713 | Use of mometasone furoate for treating upper airway diseases The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of upper and/or lower airway passages and/or lungs, e.g., allergic rhinitis ... | 04/20/2004 |
| 6713481 | Crystalline antifungal polymorph The crystalline polymorph Form I of (−)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the ... | 03/30/2004 |
| 6709676 | Extended release oral dosage composition A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount o... | 03/23/2004 |
| 6685931 | Treatment of hepatitis C virus infections with interleukin-10 The hepatoprotective effect of IL-10 is described, in particular, the use of interleukin-10 in the treatment of liver damage (e.g. fibrosis or cirrhosis) in a difficult-to-treat patient afflicted with chronic hepatitis C virus infection who has failed to ... | 02/03/2004 |
| 6677323 | Use of mometasone furoate for treating airway passage and lung diseases The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of upper and/or lower airway passages and/or lungs, e.g., allergi... | 01/13/2004 |
| 6673775 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by formula I ##STR1## wherein at least one of R2, R3 or R5 is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as ... | 01/06/2004 |
| 6635646 | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy Methods for treating treatment-naive as well as treatment-experienced adult and pediatric patients having HIV-1 infections as well as patients co-infected with HIV-1 and HCV involving administering a therapeutically effective amount of pegylated interfero... | 10/21/2003 |
| 6632455 | Molecular dispersion composition with enhanced bioavailability A molecular dispersion composition is disclosed. The molecular dispersion comprises a compound of the formula: ##STR1## molecularly dispersed in a polymer matrix. Also disclosed are solid dosage forms, e.g., tablets and capsules, containing these molecula... | 10/14/2003 |
| 6599914 | Inhibition of cytokine generation Methods of inhibiting the generation of pro-inflammatory cytokines such as IL-4 and IL-13 in a human patient in need of such inhibiting are disclosed.... | 07/29/2003 |
| 6506767 | 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine Crystalline polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cycloheptic[1,2-b ]pyridine represented by the formula ##STR1## pharmaceutical compositions containing such polymorphs, and methods of using such polymorphs to treat al... | 01/14/2003 |
| 6476062 | Chemokine receptor antagonists Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions ... | 11/05/2002 |
| 6472373 | Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection Methods for treating an antiviral treatment naive patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving administering a therapeutically effective amount of a combination therapy of ribavirin and interferon-alpha for a time... | 10/29/2002 |
| 6432972 | Treating allergic and inflammatory conditions A method of treating and/or preventing congestion associated with allergic and inflammatory conditions of the upper and lower airway passages in a human, by administering an amount of desloratadine effective for such treating and/or preventing.... | 08/13/2002 |
| 6403564 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula I and a therapeutically effective amount of in... | 06/11/2002 |
| 6337090 | Orally administrable solid ribavirin dosage forms and process for making them An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substanti... | 01/08/2002 |
| 6335347 | Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph A polymorph form 2 of ethyl 4(8-chloro-5,6,-dihydro-11H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate (hereinafter "loratadine") represented by the formula ##STR1## Pharmaceutical composition containing the polymorph form 2, and meth... | 01/01/2002 |
| 6335032 | Orally administrable solid dosage form An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substanti... | 01/01/2002 |
| 6277830 | 5'-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon 5'-Amino acid esters of ribavirin represented by formula I: ##STR1## wherein R is CH3 CH(NH2)--CO--, CH3 CH2 (CH3)CHCH(NH2)--CO--or H2 N(CH2)4 CH(NH2)... | 08/21/2001 |
| 6265414 | Treating sleep disorders using desloratadine Methods of treating and/or preventing sleep disorders in a human afflicted with upper airway passage allergic inflammation and/or congestion associated with allergic rhinitis, including seasonal allergic rhinitis or perennial allergic rhinitis, by adminis... | 07/24/2001 |
| 6262270 | Enantioselective synthesis A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula I or XIV ##STR1## or a pharmaceutically acceptable salt thereof.... | 07/17/2001 |
| 6114346 | Treating sleep disorders using desloratadine Methods of treating and/or preventing sleep disorders in a human afflicted with upper airway passage allergic inflammation and/or congestion associated with allergic rhinitis, including seasonal allergic rhinitis or perennial allergic rhinitis by administ... | 09/05/2000 |
| 6100274 | 8-chloro-6,11-dihydro-11- ] (4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions Stable pharmaceutical compositions containing 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cycloheptic[1,2-b ]pyridine("DCL") and a DCL protective amount of a pharmaceutically acceptable basic salt such as calcium dibasic phosphate and an amoun... | 08/08/2000 |
| 6051252 | Orally administrable solid dosage form An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is subsantia... | 04/18/2000 |
| 6043245 | Tetrahydrofuran antifungal phosphate A compound of the formula I ##STR1## wherein G is H or PO3 H2 or a pharmaceutical acceptable salt thereof, pharmaceutical compositions containing such compounds and method of using such compounds or pharmaceutical compositions c... | 03/28/2000 |
| 6017894 | Actinomadura fulva subsp uruguayensis and antimicrobial complex and antimicrobial compounds isolated therefrom Three novel macrolactam monosaccharides isolated from an antimicrobial complex 510 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. uruguayensis ATCC 53713.... | 01/25/2000 |
| 5972381 | Solid solution of an antifungal agent with enhanced bioavailability A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of the formula I: ##STR1## wherein: X is F; and R1 is ##STR2## or an ester or ether of said compound of Formula I; ... | 10/26/1999 |
| 5935566 | Stable aqueous alfa interferon solution formulations Stable aqueous solution formulations containing alfa-interferon type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, s... | 08/10/1999 |
| 5916594 | Process of making solid ribavirin dosage forms A process of making an orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ri... | 06/29/1999 |
| 5914128 | Orally administrable solid dosage form An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is substanti... | 06/22/1999 |
| 5883097 | Soluble azole antifungal salt The lactic acidCH3 CH(OH)CO2 H! addition salt of the compound of formula I ##STR1## wherein the molar ratio of lactic acid, preferably L-lactic acid, to the compound of formula I is preferably about 1:1, pharmaceutical composi... | 03/16/1999 |
| 5879711 | Stable antiandrogenic gel composition Pharmaceutical compositions for the topical treatment of androgen-related conditions, e.g., acne in humans containing an amount of the compound represented by formula II effective for the topical treatment of the androgen-related conditions, e.g., acne ... | 03/09/1999 |
| 5837691 | Actinomadura vulgaris subsp vulgaris and antimicrobial complex and antimicrobial A novel macrolactam monosaccharide isolated from an antimicrobial complex 517 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura vulgaris subsp. vulgaris ATCC 53748.... | 11/17/1998 |
| 5776912 | Lipophilic oligosaccharide antibiotic compositions An aqueous pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic salt, e.g., the N-methylglucamine salt of the everninomicin-type antibiotic of Formula III together with a binding agent such as human serum albumin or recombinant hu... | 07/07/1998 |
| 5766582 | Stable, aqueous alfa interferon solution formulations Process for making stable aqueous solution formulations containing alfa-type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating ... | 06/16/1998 |
| 5714490 | Tetrahydrofuran antifungals A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group su... | 02/03/1998 |
