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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7041794 | Polynucleotides and polypeptides of the erythropoietin gene The present invention relates to new polynucleotides deriving from the nucleotide sequence of the EPO gene and comprising new SNPs, new polypeptides derived from the natural EPO protein and comprising at least one mutation caused by the SNPs of the invention as well... | 05/09/2006 |
| 6500804 | Method for the improvement of islet signaling in diabetes mellitus and for its prevention The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic ଲ-cells and to cause differentiation of pancreatic ep... | 12/31/2002 |
| 6319893 | Raising blood sugar level in hypoglycemic mammals by administering inhibitors of dipeptidyl peptidase IV A method of raising the blood sugar level in a mammal having hypoglycemia is described. The method reduces degradation of glucagon by administering to the mammal a therapeutically effective amount of an inhibitor of dipeptidyl peptidase IV and physiologic... | 11/20/2001 |
| 6303661 | Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals Novel therapeutic regimens are provided which comprise the administration of therapeutically effective amounts of an inhibitor to dipeptidyl peptidase (DP-IV) or enzymes of similar activity whereby their ability to degrade the incretins, GLP-1 and GIP, is... | 10/16/2001 |
| 6232121 | Methods for the production of biologically active agents contained in an extracellular matrix The present invention relates to methods for the production in vitro of cell growth supportive surfaces comprising naturally secreted human extracellular matrix material comprising biologically active agents such as growth factors ideally produced and ela... | 05/15/2001 |
| 4983523 | Methods for preparing sample nucleic acids for hybridization A new method for releasing sample nucleic acids from cells, bacteria and viruses comprises non-invasively sonicating the sample contained within a sample container brought into physical contact with the vibrating element of a sonicator tuned to resonate a... | 01/08/1991 |
| 4743542 | Method for forestalling the hook effect in a multi-ligand immunoassay system A method is provided for substantially increasing the dynamic range of an immunoassay and forestalling the hook effect observed with very large ligand concentrations in aqueous samples. The method comprises the addition of ligand binding partners which do... | 05/10/1988 |
| 4731326 | Disease diagnosis by detection of shed normal tissue antigens Methods are provided for the detection of proximal convoluted tubule causing diseases or kidney harmful drug monitoring by detecting the presence of shed normal proximal tubule associated antigens in a body fluid such as urine. The preferred embodiment em... | 03/15/1988 |
| 4708715 | Light array assembly for photoactivation patient treatment system A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.... | 11/24/1987 |
| 4689398 | HTLV test using synthetic peptides Synthetic peptides simulating hydrophilic envelope regions and antibodies specific therefor useful for the detection of Human T-cell Leukemia virus or naturally occurring immunoglobulin against HTLV.... | 08/25/1987 |
| 4681859 | Fluorescence polarization immunoassay for heavy antigens Methods for determining the presence of large molecular weight aqueous ligands. The sample ligands are made to compete with user supplied fluorescently labeled peptides for binding sites on a ligand binding partner. Presence of aqueous ligand and binding ... | 07/21/1987 |
| 4681568 | Valve apparatus for photoactivation patient treatment system Manually overridable servo controlled valve mechanisms for controlling the flow of fluids through a flexible tube for use in a photoactivatable agent treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated ext... | 07/21/1987 |
| 4666862 | Fluorescent energy transfer with phycobiliproteins Dyes are provided comprising phycobiliproteins having covalently coupled thereto a plurality of small molecular weight organic dyes under conditions permitting energy transfer mechanisms to operate therebetween. The resultant label may then be used in vir... | 05/19/1987 |
| 4661451 | Methods for immobilizing and translocating biological cells Apparatus for immobilizing biological cells based on the dielectric properties of biological cells. An inhomogeneous electric field emanating from a grid point location or other contact area is created and attracts the biological cell into contact therewi... | 04/28/1987 |
| 4661444 | Homogeneous immunoassays employing double antibody conjugates comprising anti-idiotype antibody Homogeneous immunoassays employing double ligand binding conjugates comprising an anti-idiotype binding partner. The anti-idiotype binding partner competes with ligand for an insolubilized ligand specific binding partner. Inhibition of binding of the conj... | 04/28/1987 |
| 4647531 | Generalized cytometry instrument and methods of use A generalized cytometry instrument for measuring the kinetic properties of live cells. Cells are immobilized on a surface and their positions determined and stored in memory by a central control computer. The cells are subsequently illuminated and an opti... | 03/03/1987 |
| 4643710 | Valve apparatus for photoactivation patient treatment system Manually overridable servo controlled valve mechanisms for controlling the flow of fluids through a flexible tube for use in a photoactivatable reagent treatment system wherein photoactivatable reagents, in contact with patient blood cells, are irradiated... | 02/17/1987 |
| 4637986 | Flow cytometry lysing reagent with leukoprotective agent for producing a 3-part WBC count Lysing reagents for use in flow cytometry instruments. Lysing reagents suitable for lysing red blood cells are provided thereby permitting 3-part differential counting of white blood cells. The reagents comprise a leukoprotective agent for preserving the ... | 01/20/1987 |
| 4623328 | Pump monitor for photoactivation patient treatment system A preferred patient blood treatment system for the photoactivation of reagents in contact with a patient's blood employs an infusion pump for adding anti-coagulation reagent to the blood during extracorporeal operations. The infusion pump is preferably dr... | 11/18/1986 |
| 4597966 | Histidine stabilized immunoglobulin and method of preparation Histidine-stabilized immunoglobulin preparations and a method for their manufacture are disclosed. The present invention is particularly well suited for stabilization of human gamma globulin (IgG) preparations having a relatively low protein content. Pref... | 07/01/1986 |
| 4596550 | Method and apparatus for ultrafiltration measurement in a two pump dialysis system A blood flow system for processing blood has two phases of operation, an arterial phase and a venous phase. During the arterial phase, the system is filled with blood through operation of an arterial blood pump. When a predetermined blood pressure level i... | 06/24/1986 |
| 4596547 | Valve apparatus for photoactivation patient treatment system Manually overridable servo controlled valve mechanisms for controlling the flow of fluids through a flexible tube for use in a photoactivatable reagent treatment system wherein photoactivatable reagents, in contact with patient blood cells, are irradiated... | 06/24/1986 |
| 4596035 | Methods for enumerating 3-part white cell differential clusters Methods useful for differentiating and enumerating subpopulations of particles in a sample and more particularly relates to the enumeration of leukocyte subclasses. Enumeration is accomplished by utilizing two light scatter parameters and converting these... | 06/17/1986 |
| 4581334 | Simultaneous detection of leukocyte phagocytic and killing ability Methods for the determination of phagocytic and killing ability of selected leukocyte subclasses based upon the use of three part differentials obtained by light scatter characteristics and gated fluorescence. Particles having multiple fluorescent labels ... | 04/08/1986 |
| 4578056 | Patient photopheresis treatment apparatus and method Provided are apparatus and methods of use for extracorporeally treating a patient whereby blood is withdrawn from the patient, separated into a leukocyte enriched portion which, in contact with a photoactivatable reagent, is irradiated and all blood porti... | 03/25/1986 |
| 4574876 | Container with tapered walls for heating or cooling fluids Flexible container means for the warming or cooling of fluids. A preferred embodiment, useful for the warming of plasma following cryogellation techniques prior to its return to the patient, comprises container means formed by the heat sealing of polymeri... | 03/11/1986 |
| 4573962 | Cassette drawer assembly for photoactivation patient treatment system Cassette drawer assembly for receiving an irradiation cassette wherein patient blood is irradiated to photoactivate a reagent in contact therewith, said irradiated blood being returned to the patient as part of the complete treatment.... | 03/04/1986 |
| 4573960 | Three phase irradiation treatment process In a system for altering cells such as by irradiating said cells when in contact with a photoactivatable reagent useful for the extracorporeal treatment of a patient's blood, a three phase method for performing the operations in a safe and efficacious man... | 03/04/1986 |
| 4573961 | Electronic control methods for puvapheresis apparatus Methods are provided for ensuring the safety of a patient undergoing extracorporeal treatment by irradiation of a photoactivatable reagent in contact with the patient's blood including simultaneous digital and analog monitoring of temperature, voltage and... | 03/04/1986 |
| 4568328 | Automated photophoresis blood portion control methods and apparatus Automated control methods and apparatus are provided for the separation and collection of desired blood portions for use in an extracorporeal photophoresis treatment system wherein a photoactivatable agent, in contact with leukocyte enriched blood from a ... | 02/04/1986 |
| 4546770 | Pulmonary monitor A pulmonary monitor for measuring a complex set of variables utilizing a group of three pushbuttons arranged to operate in hierarchical a hierarchical pattern for facilitating operator control of the functions of the monitor.... | 10/15/1985 |
| 4501583 | Hemodialysis access monitors A monitoring arrangement is provided for detecting for extreme pressure conditions in blood tubing lines of a hemodialysis system. The arrangement includes a first pushbutton switch and a pivoted lever arm. A clamping means is located at a first end of th... | 02/26/1985 |
| 4499183 | Detecting intracellular antigens in swelled and fixed cells with labeled antibody Methods and reagent kits for the detection of intracellular antigens such as TdT and antinuclear antibodies. The methods involve swelling the cells with a hypotonic solution for increasing the localization of large molecular weight substances such as anti... | 02/12/1985 |
| 4498982 | Reverse osmosis water purification system A reverse osmosis system including a high pressure pump and pump motor is enclosed in an unvented enclosure to reduce the amount of noise which would otherwise be transmitted into the surrounding environment. The pump motor is cooled by the flow of inlet ... | 02/12/1985 |
| 4492752 | Method for discriminating between unstained and absorbing dye stained cells Method for discriminating unstained cells from stained cells in a heterogeneous population. Specified cell types are stained with an absorbing stain and all cells are passed through the class of flow cytometry instrumentation employing focused collimated ... | 01/08/1985 |
| 4490135 | Single needle alternating blood flow system A two-pump single needle hemodialysis system is provided in which a flexible blood accumulator bag is located between the dialyzer and the second, venous blood pump. The accumulator bag is filled as the first, arterial blood pump is operated. Blood is pum... | 12/25/1984 |
| 4490134 | Dual phase blood flow system and method of operation A blood flow system for processing blood has two phases of operation, an arterial phase and a venous phase. During the arterial phase, the system is filled with blood through operation of an arterial blood pump. When a predetermined blood pressure level i... | 12/25/1984 |
| 4487839 | Immunoassay methods employing patterns for the detection of soluble and cell surface antigens Methods for determining the presence of antigens or antibodies in an aqueous sample or presence of antigens on the surface of cells. A preferred embodiment employs fluorescent antigens which compete with the sample antigens for antibody binding sites. The... | 12/11/1984 |
| 4487601 | Bubble detector circuit with variable reference level A bubble detector system is provided which dynamically responds to changes in energy transmission efficiency. The output of a detector is coupled to a dynamic reference level circuit, which develops a reference level that changes slowly in a time-varying ... | 12/11/1984 |
| 4486189 | Dual mode hemodialysis system A hemodialysis system capable of operation in either a single needle mode or a double needle mode includes an arterial blood pump which is the sole blood pump in the system during the double needle mode. For single needle mode operation a venous blood pum... | 12/04/1984 |
