Hess; Susan L. - US Patent Attorneys and Agents

Attorney: Hess; Susan L.

Number of patents: 33
Last date: May 22, 2012

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Number	Title	Issue Date
8183276	Therapeutic agents The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed. ...	05/22/2012
8163956	Inhibitors of GLYT1 transporters A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are ...	04/24/2012
8129397	Substituted thieno[2,3-d]pyrimidines as AMPA modulators The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention...	03/06/2012
8058441	Tetrahydroquinoline derivatives The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is formyl, (1-6C)alkylcarbonyl or (1-6C)alkylsulfonyl; R2 and R3 are H or (1-4C)alk...	11/15/2011
8058436	Method for the preparation of enantiomerically pure mirtazapine The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with ...	11/15/2011
8034804	(Pyrido/thieno)-[f]-oxazepine-5-one derivatives The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula I wherein R1, R2 and R3 are independently H or (C1-4)alkyl; Ar represen...	10/11/2011
8026236	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for t...	09/27/2011
7998958	Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors Disclosed are novel gamma secretase inhibitors of the formula: Also disclosed are methods for inhibiting gamma secretase, for treating one or more neurodegenerative diseases, for inhibiting the deposition of beta amyloid prot...	08/16/2011
7994314	Method for the preparation of an enantiomerically pure benzazepine The invention relates to the preparation of mirtazapine precursors and mirtazapine preferably having a substantial enantiomeric excess. ...	08/09/2011
7985758	Piperidine derivatives for treatment of Alzheimer's disease Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions. ...	07/26/2011
7960560	1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione The invention relates to A 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivative having the general Formula I wherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, OR4, COOR	06/14/2011
7960365	Compounds with medicinal effects due to interaction with the glucocorticoid receptor The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R	06/14/2011
7947714	Piperidine glycine transporter inhibitors The present invention is directed to piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseas...	05/24/2011
7932251	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for t...	04/26/2011
7906504	2-(1-oxo-1-isoquinolin-2-yl)acetamide derivatives Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the spec...	03/15/2011
7893088	6-substituted isoquinoline derivatives The present invention relates to 6-substituted isoquinoline derivatives having the general Formula I wherein X is O, S or NH; Y is OH or NH2; m is 0, 1 or 2; n is 0 or 1; o is 0 or 1; R1 is H, when Y i...	02/22/2011
7868193	16,17-carbocyclic condensed steroid compounds having selective estrogenic activity The invention discloses a steroid compound having the formula (1), wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C	01/11/2011
7868017	9-azabicyclo[3.3.1]nonane derivatives The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable s...	01/11/2011
7858794	Tetrahydroquinoline derivatives The present invention relates to tetrahydroquinoline derivatives having gene formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are H or Me; R3 is H, hydroxy, (1-4C)alkoxy, (di)(1-4C)alkylamino(2-4C)alkoxy o...	12/28/2010
7838518	1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders The present invention relates to 1-arylsulfonyl-3 substituted indole or indoline derivatives having the general formula (I) (I) wherein the dotted line represents an optional bond; n is 0 or 1; m is 0-5 and Ar, R6-R11 are defined in the description. The invention fu...	11/23/2010
7838516	15 β-substituted steroids having selective estrogenic activity The invention provides 15β-substituted steroidal compounds having selective estrogen receptor activity according to Formula I: wherein, R1 is H, C1-5 alkyl, C1-...	11/23/2010
7820707	Heterocyclic derivatives The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention...	10/26/2010
7820649	Quinazolinone and isoquinolinone acetamide derivatives Disclosed herein are quinazolinone or isoquinolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specifica...	10/26/2010
7812036	Androgens The compounds of the subject invention have a structure according to formula I: wherein each of the substituents is given the definition as set forth in the specification and claims, or a salt or hydrate form thereof. ...	10/12/2010
7807686	2-(4-oxo-4H-quinazolin-3-yl)acetamides and their use as vasopressin V3 antagonists The present invention relates to 2-(4-oxo4H-quinazolin-3-yl) acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression. ...	10/05/2010
7795280	Indoles useful in the treatment of androgen-receptor related diseases This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof.	09/14/2010
7763732	Indole derivatives Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing th...	07/27/2010
7737136	Non-steroidal progesterone receptor modulators The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-...	06/15/2010
7051906	Package for a pharmaceutical product and method of sterilizing the package The invention provides a pharmaceutical package including a polypropylene bottle in which is disposed a solution containing a pharmaceutical product, where the solution does not fill the bottle completely and some air is disposed in the bottle, and where the package...	05/30/2006
6921757	Organic compounds Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals ...	07/26/2005
6777429	Ophthalmic composition The present invention is related to an ophthalmic composition comprising ketotifen as a pharmaceutically active agent. ...	08/17/2004
6774137	Ophthalmic composition The present invention is related to an ophthalmic composition comprising ketotifen as a pharmaceutically active agent. ...	08/10/2004
6670379	Piperidine compounds for use as ccr-3 inhibitors ##STR1## Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more halogen atoms, Ar2 is phenyl or naphthyl which is unsubstituted or substituted by one or more substituents selected from halogen, ...	12/30/2003

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Attorney: Hess; Susan L.