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| Number | Title | Issue Date |
| 8067621 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bo... | 11/29/2011 |
| 7989442 | Progesterone receptor modulators The present invention provides new progesterone receptor modulators which are (cis)-8-fluorodibenzo[b,f]pyrido[1,2-d]oxazepine-1-amine compounds and uses thereof. ... | 08/02/2011 |
| 7772227 | Tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives as cannabinoid CB1 receptor agonists The invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivative having the general Formula (I) wherein X is CH2, O or S; R represents 1-3 substituents independently selected from H, (C1-4)alkyl, (C1-4)alkyloxy and ha... | 08/10/2010 |
| 7700634 | (Indol-3-yl) heterocycle derivatives as agonists of the cannabinoid CB1 receptor Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing th... | 04/20/2010 |
| 7696190 | 16Alpha-methyl or ethyl substituted estrogens The invention makes a 16α-substituted steroidal compound available having formula 1, wherein the dotted ring is a fully saturated, a fully aromatic or a saturated ring with a Δ5-10 double bond; R1 is (C1-C3)alkyl or (C2-... | 04/13/2010 |
| 7691836 | Progesterone receptor modulators The subject invention provides a compound according to Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt and/or hydrate f... | 04/06/2010 |
| 7687515 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I wherein each of the substituents is given the definition as set forth in the specification and clai... | 03/30/2010 |
| 7674909 | Tetrahydroquinoline derivatives and their use as FSH receptor modulators The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are H, Me; R3 is (2-6C)heterocycloalkyl(1-4C)alkyl, (2-5C)heteroaryl(1-4C)al... | 03/09/2010 |
| 7671080 | 1-benzylindole-2-carboxamide derivatives The present invention relates to i-benzylindole-2-carboxamide derivatives of formula I, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 1-benzylindole-2-carboxamide derivatives and t... | 03/02/2010 |
| 7655653 | Tetrahydrobenzfluorene derivatives A compound having the formula I wherein the O—(CH2)n—N(R1,R2) substituent on the phenyl ring can be in meta or para position; n is 2-4 R... | 02/02/2010 |
| 7655645 | Indole derivatives The invention relates to indole derivative having the general Formula I wherein A represents a 5-membered aromatic heterocyclic ring, wherein X1, X2 and X3 are independently selected from N,... | 02/02/2010 |
| 7618985 | Isoquinoline derivatives The invention relates to isoquinoline derivatives having the general Formula I wherein X is O, S or NH; Y is OH or NH2; m is 0, 1 or 2; n is 1 or 2; R1 is H, when Y is NH2; or R1 ... | 11/17/2009 |
| 7618963 | Bicyclic heteroaromatic compounds A bicyclic heteroaromatic compound according to general formula I, or a pharmaceutically acceptable salt thereof, wherein R1 is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl; all op... | 11/17/2009 |
| 7605170 | 8-azabicyclo[3.2.1]octane derivatives The present invention relates to a 8-azabicyclo[3.2.1] octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable ... | 10/20/2009 |
| D601337 | Pill case for holding a blister pack | 10/06/2009 |
| 7589095 | 4-phenyl-pyrimidine-2-carbonitrile derivatives The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula I wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutical... | 09/15/2009 |
| 7582622 | Steroids having a mixed androgenic and progestagenic profile The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to the formula (I) wherein, R... | 09/01/2009 |
| 7566778 | (Pyrido/thieno)-[f]-oxazepine-5-one derivatives The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula I wherein R1, R2 and R3 are independently H or (C1-4)alkyl; Ar represen... | 07/28/2009 |
| 7531571 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having formula 1 wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl gr... | 05/12/2009 |
| 7528123 | Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11 Disclosed is a novel class of steroid compounds based on estradiol, and carrying an 11β-substitution. Said substitution is a hydrocarbon group which may be linear or branched, provided that it comprises, as the longest chain on carbon atom no. 11 of the steroid ske... | 05/05/2009 |
| 7514236 | Identification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499-1695 of SEQ ID NO:1 or by nucleotides 387-1427 of SEQ ID NO:2, respectivel... | 04/07/2009 |
| 7507824 | Spiro(2H-1benzopyran-2,4′-piperidine) derivates as glycine transport inhibitors The present invention relates to spiro[2H-1-benzopyran-2,4′-piperidine] derivatives having general formula (I), or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising sa... | 03/24/2009 |
| 7504390 | Benzoxazepine derivatives and their use as AMPA receptor stimulators The present invention relates to benzoxazepine derivative having the general formula I, wherein X represents CO or SO2; R1, R2, R3 and R4 are independently selected from H, (C1-4)alkyl, (C1-4 | 03/17/2009 |
| 7482469 | 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives The invention relates to 2-(benzimidazol-1-yl)-acetamide bisaryl derivative having the general Formula I wherein n is 0 or 1; Ar1 represents a diradical derived from a 5- or-6-membered aromatic ring, optionally c... | 01/27/2009 |
| 7459425 | Reagents for protection of peptide/proteins carbamylation in urea solutions utilizing non-ethylene-diamine like compounds The present invention generally relates to non-ethylene diamine like compounds that prevent and/or delay carbamylation of peptides. ... | 12/02/2008 |
| 7435817 | C-14 oxidation of morphine derivatives The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (... | 10/14/2008 |
| 7435791 | Process for rapid solution synthesis of peptides The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d): (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, | 10/14/2008 |
| 7432075 | Indentification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499-1695 of SEQ ID NO:1 or by nucleotides 387-1427 of SEQ ID NO:2, respectivel... | 10/07/2008 |
| 7396854 | Use of serotonergic compound for a method of treatment of hot flushes in post-menopausal women The present invention relates to a method of treatment of hot flushes with a 5-HT2C receptor agonist and in particular to the use of the selective 5-HT2C receptor agonists 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine and (S)-(+)-3-[(... | 07/08/2008 |
| 7375109 | Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity The present invention resides in glycine substituted thieno[2,3-d]pyrimidine derivatives according to general formula I, or a pharmaceutically acceptable salt thereof, wherein X is O or H,... | 05/20/2008 |
| 7375106 | Synergistic combination of an opioid analgesic and a NSAID The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given sequentially or simultaneously can be used for the treatment of pain diminis... | 05/20/2008 |
| 7357046 | Method for dissolution testing of a pharmaceutical delivery device The invention relates to a vessel for dissolution testing of a pharmaceutical delivery device, comprising: an inert vessel wall and an inert vessel bottom such that the vessel is able to hold a fluid medium; an inert retainer provided by or at the vessel wall or ves... | 04/15/2008 |
| 7354728 | Coactivation of nuclear receptors The invention provides a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as the use of a polynucleotide encoding such protein, for use in an assa... | 04/08/2008 |
| 7345036 | (Pyrido/thieno)—[f]—oxazepine-5-one derivatives The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula (I) or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of th... | 03/18/2008 |
| 7335659 | Substituted 10-aryl-11-benzo[]fluorenes and 7-aryl-5, 6-dihydro-benzo[]anthracenes for selective effects on estrogen receptors This invention provides a compound, or its possible salt, having the formula, wherein: Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or... | 02/26/2008 |
| 7329510 | Full length human HCN1Ichannel subunit and variants This invention relates to a DNA sequence encoding a member of the hyperpolarized activated ion channel family (HCN) and variants thereof, and the use of said sequences in assays for the measurement of gene expression. It also relates to assays for screening of I | 02/12/2008 |
| 7326715 | 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives Disclosed herein are 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives having Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims; or a phar... | 02/05/2008 |
| 7323454 | Etonogestrel esters The subject invention provides new progestogen esters and uses thereof. ... | 01/29/2008 |
| 7320873 | Use of antibodies against specific MHC-peptide complexes The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune disease. The MHC-peptide complex is associated with rheumatoid arthritis. M... | 01/22/2008 |
| 7317006 | Thieno[2,3-]pyrimidines with combined LH and FSH agonistic activity The invention relates to thieno[2,3-d]pyrimidine derivatives according to general formula I, or a pharmaceutically acceptable salt thereof, wherein N(R1)R2 are joined in a (2-6C)heterocycloalkyl ring. The compoun... | 01/08/2008 |
