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| Number | Title | Issue Date |
| 5863528 | Porcine cytokines A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at leas... | 01/26/1999 |
| 5827740 | Adipogenic differentiation of human mesenchymal stem cells A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into t... | 10/27/1998 |
| 5811094 | Connective tissue regeneration using human mesenchymal stem cell preparations Isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particu... | 09/22/1998 |
| 5736396 | Lineage-directed induction of human mesenchymal stem cell differentiation Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of ch... | 04/07/1998 |
| 5736367 | Vectors and prokaryotes which autocatalytically delete antibiotic resistance A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular ... | 04/07/1998 |
| 5733542 | Enhancing bone marrow engraftment using MSCS Method and preparations for enhancing bone marrow engraftment in an individual by administering (i) a culturally expanded mesenchymal stem cell preparation and (ii) a bone marrow graft. The mesenchymal stem cells are administered in an mount effective to ... | 03/31/1998 |
| 5703073 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d... | 12/30/1997 |
| 5648393 | Treatment of male impotence with s-nitrosylated compounds Methods of relaxing corpus cavernosum smooth muscle, treating disease states responsive to prevention or relaxation of undesirable contractions of corpus cavernosum smooth muscle and of treating male impotence by administering an S-nitrosothiol such as a ... | 07/15/1997 |
| 5643736 | Monoclonal antibodies for human osteogenic cell surface antigens Monoclonal antibodies specific for normal human osteogenic cell subsets and the monoclonal hybridoma cell lines that synthesize and secrete these monospecific antibodies, as well as the uses of the monoclonal antibodies for diagnostic and/or therapeutic p... | 07/01/1997 |
| 5612314 | Nitrosylated neuropeptides Neuropeptides, particularly vasoactive intestinal peptide(VIP) and fragments, mutations and derivatives thereof that have corresponding activities to which have been directly or indirectly linked at least one NO or NO2 group, and their uses, in... | 03/18/1997 |
| 5599917 | Inhibition of interferon-γ with oligonucleotides Oligonucleotides and analogs thereof that bind to and preferably modulate the activity of interferon-γ, and methods for their use, including therapeutic and diagnostic methods are disclosed.... | 02/04/1997 |
| 5593876 | Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 01/14/1997 |
| 5591625 | Transduced mesenchymal stem cells Genetically engineered human stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins or for use in gene therapy. In addition to correction of genetic disorders, is the abi... | 01/07/1997 |
| 5589582 | Polynucleotides en coding porcine cytokines A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at leas... | 12/31/1996 |
| 5583101 | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contract... | 12/10/1996 |
| 5574068 | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Th... | 11/12/1996 |
| 5545614 | Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a skeletal muscle relaxing amount of nitroxyl ion(NO-), ... | 08/13/1996 |
| 5536723 | S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier. The invention also relates to methods for ... | 07/16/1996 |
| 5486359 | Human mesenchymal stem cells Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem ... | 01/23/1996 |
| 5484608 | Sustained-release drug delivery system A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created ... | 01/16/1996 |
| 5459076 | Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems Nitric oxide, nitrosonium, S-nitrosothiols, and S-nitroso-proteins can be detected in biological samples, using a method which involves injection of samples into a photolysis cell, prior to detection of chemiluminescence generated by the reaction between ... | 10/17/1995 |
| 5447729 | Multilamellar drug delivery systems A pharmaceutical preparation including a pharmaceutical agent incorporated into particles comprising (i) a core formed from a hydrophilic material, a hydrophobic material or a hydrophobic emulsion or dispersion and (ii) an alternating sequence of hydrophi... | 09/05/1995 |
| 5427797 | Systemic effects of nitric oxide inhalation Nitric oxide or nitric oxide releasing or delivering compounds administered by the inhalation route to humans and animals in need thereof have a systemic and pulmonary effect of preventing or treating blood platelet aggregation and coagulation and thus, a... | 06/27/1995 |
| 5385937 | Nitrosation of homocysteine as a method for treating homocysteinemia Administration of a nitrosating compound, such as nitroglycerin, nitric oxide, S-nitrosothiol, S-nitroso-protein, nitroprusside, sydnonimines, furoxans, nitrosonium salts, and related compounds is used for the treatment or prevention of disease states res... | 01/31/1995 |
| 5380758 | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Th... | 01/10/1995 |
| 5298506 | Use of guanylate cyclase inhibitors in the treatment of shock The invention relates to the administration of guanylate cyclase inhibitors, such as methylene blue, for the treatment of septic shock, cardiogenic shock, hypovolemic shock, obstructive shock, neuropathic shock and hypotension caused by excessive doses of... | 03/29/1994 |
