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| Number | Title | Issue Date |
| 7649015 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other... | 01/19/2010 |
| 7439350 | Nucleotide analogs Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed i... | 10/21/2008 |
| 7390791 | Prodrugs of phosphonate nucleotide analogues A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of t... | 06/24/2008 |
| 6818633 | Antiviral compounds and methods for synthesis and therapy Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods fo... | 11/16/2004 |
| 6653296 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula (IA) and (IB) ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 11/25/2003 |
| 6635278 | Pharmaceutical formulations The invention provides compositions comprising the nucleotide analog 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and an alkaline excipient with or without L-carnitine-L-tartrate. The compositions are more stable those previously describ... | 10/21/2003 |
| 6479231 | Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1 (hOAT1) Secretion of small molecules from systemic blood circulation into urine is one of the physiologically essential functions of the kidney. Human organic anion transporter (hOAT1) is a key component in the renal tubular secretion of negatively charged molecu... | 11/12/2002 |
| 6479673 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 11/12/2002 |
| 6465649 | Methods for the dealkylation of phosphonate esters Disclosed are methods for the dealkylation of phosphonate esters by use of trimethylchlorosilane as the dealkylating agent. In particular, this invention is directed to the discovery that high yields for the dealkylation of phosphonate esters can be achie... | 10/15/2002 |
| 6451340 | Nucleotide analog compositions The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its form... | 09/17/2002 |
| 6432631 | Gene encoding organic anion transporter This invention is concerned with human organic anion transporter ("hOAT"). Isolated nucleic acid encoding hOAT is provided, along with isolated hOAT polypeptide. hOAT nucleic acid and/or hOAT polypeptide are employed in transgenic animals, recombinant cel... | 08/13/2002 |
| 6225460 | Nucleotide analogs Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is h... | 05/01/2001 |
| 6110721 | Polypeptides and coagulation therapy Novel polypeptides (NPs) are provided which are capable of protein C activation without significant fibrinogen clotting activity, and vice versa. NPs having enhanced protein C activating properties in relation to fibrinogen clotting are useful in particul... | 08/29/2000 |
| 6069249 | Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R2)2 OC(O)X(R)a, wherein R2 independently is H, C | 05/30/2000 |
| 6057305 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 05/02/2000 |
| 6005096 | Pyrimidine derivatives A compound having the structure ##STR1## wherein R1 is H or a linker group; R24 is independently halo or C1 -C2 haloalkyl; R25 is independently --SH, --OH, .dbd.S or .dbd.O; A is independently N or C;... | 12/21/1999 |
| 5977061 | N6 - substituted nucleotide analagues and their use Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic ... | 11/02/1999 |
| 5977089 | Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability Compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R2)2 OC(O)X(R)a, wherein R2 independently is H, C1 | 11/02/1999 |
| 5935946 | Nucleotide analog composition and synthesis method The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis.... | 08/10/1999 |
| 5869467 | 9-(2-phosphonylmethoxyethyl) guanine This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of py... | 02/09/1999 |
| 5854228 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk1 alk2 and alk3 ar... | 12/29/1998 |
| 5837871 | Nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are h... | 11/17/1998 |
| 5792756 | Prodrugs of phosphonates There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may a... | 08/11/1998 |
| 5767100 | Compounds and methods for making and using same In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame re... | 06/16/1998 |
| 5763588 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) ##STR1## wherein R1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the tota... | 06/09/1998 |
| 5756486 | Method for dosing therapeutic compounds The internally cyclized congeners of hydroxy-substituted nucleotide analogues have been found to exhibit substantially lower toxicity in vivo than their uncyclized analogues, while retaining essentially the same antiviral activity. This was unexpected bec... | 05/26/1998 |
| 5750729 | Compounds and methods for making and using same In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame re... | 05/12/1998 |
| 5733896 | N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, their preparation and use N-(3-Fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, method of producing them and their use as active principles of drugs. The invention relates to suppression of multiplication of viruses, particularly retroviru... | 03/31/1998 |
| 5733788 | PMPA preparation Purified preparations of PMPA are provided, together with analytical methods for the detection of undesired contaminants in PMPA preparations. The PMPA compositions of the invention are of particular utility in therapeutics intended for the treatment or p... | 03/31/1998 |
| 5726174 | Nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyridimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and ar... | 03/10/1998 |
| 5696265 | Vinyl ethers of nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are h... | 12/09/1997 |
| 5696263 | Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives Compounds are provided that generally have the structure BCH2 CH(R)OCH2 P(O)(OH)2, wherein B is a purinyl or pyrimidinyl base and R is C1-2 alkyl substituted with azido or amino, straight or branched alkenyl of ... | 12/09/1997 |
| 5693798 | Phosphonate nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are h... | 12/02/1997 |
| 5693771 | Methods for making nucleoside analogs In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame re... | 12/02/1997 |
| 5688778 | Nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are h... | 11/18/1997 |
| 5686611 | Nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are h... | 11/11/1997 |
| 5686629 | Method and cyclic carbonates for nucleotide analogues An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed ... | 11/11/1997 |
| 5663159 | Prodrugs of phosphonates There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may a... | 09/02/1997 |
| 5650510 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk1 alk2 and alk3 ar... | 07/22/1997 |
| 5641763 | N-phosphonylmethoxyalkyl derivatives of pyrimdine and purine bases and a therapeutical composition therefrom with antiviral activity This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of py... | 06/24/1997 |
