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| Number | Title | Issue Date |
| 6870034 | Protein purification A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers. ... | 03/22/2005 |
| 6821956 | Therapeutic use of cis-element decoys in vivo The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes involved in cell growth, differentiation and signalling or to viral g... | 11/23/2004 |
| 6818394 | High density immobilization of nucleic acids Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nu... | 11/16/2004 |
| 6812335 | Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated. ... | 11/02/2004 |
| 6803194 | Use of ribozymes for functionating genes Double stranded DNAs, expression vectors and methods for their use are provided in which the intracellular expression of the double stranded DNAs is used to alter the phenotype of a target cell so that the function of a target nucleic acid that includes a nucleotide... | 10/12/2004 |
| 6790458 | Pharmaceutical compositions using semi-solid delivery vehicle A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is su... | 09/14/2004 |
| 6750321 | Insulin-like growth factor agonist molecules Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal. ... | 06/15/2004 |
| 6723564 | IR MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 04/20/2004 |
| 6722370 | Delivery of a composition to the liver by utilizing the portal vein In general, the invention features methods for delivering a composition to the liver in a non-surgical, percutaneous approach by utilizing the portal vein. Also disclosed are methods allowing for the liver-specific delivery of a composition. ... | 04/20/2004 |
| 6716586 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal. ... | 04/06/2004 |
| 6713451 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal. ... | 03/30/2004 |
| 6706530 | IR-MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 03/16/2004 |
| 6696473 | Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear r... | 02/24/2004 |
| 6693079 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 02/17/2004 |
| 6693078 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 02/17/2004 |
| 6689751 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 02/10/2004 |
| 6689356 | Recombinant baculoviruses producing insect toxins A recombinant baculovirus is provided with a genetic coding sequence for the production of a foreign protein that is toxic to insects. Preferred are nuclear polyhedrosis viruses, with preferred embodiments having been constructed and expressed in insect c... | 02/10/2004 |
| 6683103 | Sulfonamides for treatment of endothelin-mediated disorders Thienylsulfonamides and their pharmaceutically acceptable derivatives, pharmaceutical compositions, articles of manufacture, combinations, lyophilized powders and methods for the treatment of endothelin diseases using these formulations and sulfonamides a... | 01/27/2004 |
| 6680298 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 01/20/2004 |
| 6677305 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 01/13/2004 |
| 6660229 | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing Methods and kits that use nucleotide analogs to confer increased accuracy and improved resolution in the analysis and sequencing of oligonucleotide mixtures are provided.... | 12/09/2003 |
| 6656466 | Human tumor necrosis factor--immunoglobulin(TNFR1-IgG1) chimera composition The present invention relates to novel process for the preparation of glycoproteins by mammalian cell culture wherein the sialic acid content of the glycoprotein produced is controlled over a broad range of values by manipulating the cell culture environm... | 12/02/2003 |
| 6645775 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 11/11/2003 |
| 6637881 | Eyecup shield with finger ports An eyecup shield for use during ocular examinations. The eyecup shield is formed from a cylindrical member having a proximal end with an opening, a distal end with an opening, and a wall. The wall is substantially rigid and has one or more access ports wh... | 10/28/2003 |
| 6632794 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 10/14/2003 |
| 6620789 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 09/16/2003 |
| 6610296 | Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin The present invention provides methods of enhancing cognitive function in mammals by administering intracerebrally a homo-multimeric immunoadhesin molecule that contains the extracellular domain of AL-1, also known as ephrin-A5.... | 08/26/2003 |
| 6608031 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mam... | 08/19/2003 |
| 6602274 | Targeted transcutaneous cancer therapy The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provide... | 08/05/2003 |
| 6599232 | Needle spin for medical instrument A medical instrument includes a distal frame portion that accepts a needle cam. The needle cam has helical slots for accepting a collar, whereby the collar rides up and down the needle cam, to thereby cause the needle cam to rotate. Spin movement of the n... | 07/29/2003 |
| 6592508 | Fiberoptic-guided interstitial seed manual applicator and seed cartridge A method and apparatus for implanting seeds in or about a target area, such as a tumor, within a patient. The implantation device includes an implantation needle having a bore extending a longitudinally therethrough from a proximal end to a distal end of ... | 07/15/2003 |
| 6582904 | Method of quantifying tumour cells in a body fluid and a suitable test kit A method for the quantification of tumor cells in a body fluid is disclosed and entails first carrying out a reaction with the sample to be investigated, in which the RNA component of telomerase is specifically amplified, and then the amount of amplified ... | 06/24/2003 |
| 6576650 | Peripherally active anti-hyperalgesic opiates Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate rece... | 06/10/2003 |
| 6573362 | Cythohesin-PH peptides that affect the ability of integrins to adhere Isolated cytohesin-PH peptides that can inhibit the beta-2 integrins from adhering, wherein the cytohesin-PH peptide has an amino acid sequence that comprises about a 140 amino acid domain from cytohesin-2. Assay kits comprising the peptides also are prov... | 06/03/2003 |
| 6566513 | Lentivirus from the group of immunodeficiency viruses of drill monkeys (Mandrillus leucophaeus) and their use The present invention relates to an immunodeficiency virus of drill monkeys, its RNA, the corresponding cDNA, proteins derived therefrom and fragments of the nucleic acids or proteins. The invention likewise relates to the diagnostic use of the nucleic ac... | 05/20/2003 |
| 6566390 | Substituted and unsubstituted benzooxathiazoles and compounds derived therefrom The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.... | 05/20/2003 |
| 6566091 | Neurotrophic factor A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided here... | 05/20/2003 |
| 6566055 | Methods of preparing nucleic acids for mass spectrometric analysis This invention relates to methods for screening nucleic acids for polymorphisms by analyzing amplified target nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting... | 05/20/2003 |
| 6559295 | Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can ... | 05/06/2003 |
| 6558902 | Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules Mixtures containing a biological macromolecule, such as a nucleic acid molecule or a polypeptide, and a liquid matrix, which absorbs infrared (IR) radiation, are provided. These mixtures are useful for analysis of the biological macromolecule by IR matrix... | 05/06/2003 |
