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| Number | Title | Issue Date |
| 7736639 | Method of treating cancer by administering conjugates comprising human IL-18 and substitution mutants thereof Methods of treating cancer in patients in need thereof with human interleukin-18 (IL-18) polypeptides and substitution mutants thereof that are conjugated to water-soluble polymers at specific sites on the human IL-18 protein are disclosed. ... | 06/15/2010 |
| 7655425 | Uses of a chemokine receptor able to bind to MCP-1, MIP-1α and/or RANTES A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated... | 02/02/2010 |
| 7595039 | Methods of healing wounds by administering human IL-18 The present invention relates generally to the use of human IL-18, also known as interferon-γ-inducing factor (IGIF), in the treatment of skin wounds, surgical wounds, leg ulcers, diabetic ulcers, gastrointestinal mucositis, oral mucositis, and lung injury. ... | 09/29/2009 |
| 7442526 | Method for preparing a physiologically active IL-18 polypeptide The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”). ... | 10/28/2008 |
| 7399593 | Member of the TNF ligand family The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprising: i) a polypeptide having the amino acid sequence of FIG. (1) or ii) a variant of the polypeptide of i). ... | 07/15/2008 |
| 7368537 | Subunit vaccine against respiratory syncytial virus infection The present invention relates generally to methods of treating or preventing RSV infections, and more specifically, to compositions, and the use thereof, comprising one or more RSV G protein immunogen or fragment thereof capable of eliciting protective immunity with... | 05/06/2008 |
| 7316813 | Influenza vaccine composition An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilized in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may com... | 01/08/2008 |
| 7311902 | Conjugates comprising human IL-18 and substitution mutants thereof Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjuga... | 12/25/2007 |
| 7285280 | Vaccine The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly ... | 10/23/2007 |
| 7253260 | Human IL-18 crystal structure A novel human IL-18 native crystalline structure is identified. ... | 08/07/2007 |
| 7238349 | Composition The invention provides a monovalent influenza vaccine comprising a low dose of egg-derived influenza virus antigen from an influenza virus strain that is associated with a pandemic outbreak or has the potential to be associated with a pandemic outbreak, in combinati... | 07/03/2007 |
| 7186528 | Method for preparing a physiologically active IL-18 polypeptide A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease. ... | 03/06/2007 |
| 7008623 | Antibodies to CD23, derivatives thereof, and their therapeutic uses The invention relates to antibodies which bind to the CD23 (FCεRII) type II molecule particularly altered antibodies including antibodies which bind to the CD23 (FCεRII) type II molecule characterized by an affinity constant equal to or greater than 1×109 | 03/07/2006 |
| 6936698 | Monoclonal antibodies with reduced immunogenicity Antibodies having reduced immunogenicity and methods for making them are disclosed. ... | 08/30/2005 |
| 6881827 | Molecular cloning of a 7TM receptor (AXOR34) and screening methods thereof AXOR34 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR34 polypeptides and polynucleotides in diagnostic assays. Further disclosed are screening assays... | 04/19/2005 |
| 6750026 | Screening methods using ligands of the neutropeptide receptor HFGAN72 Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, method... | 06/15/2004 |
| 6706487 | Monoclonal antibody and the method of using the antibody Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided. ... | 03/16/2004 |
| 6664229 | Methods for treatment using novel ligands of the neuropeptide receptor HFGAN72 Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose or treat diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided.... | 12/16/2003 |
| 6365389 | Human protein kinase H2LAU20 The H2LAU20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H2LAU20 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 04/02/2002 |
| 6361967 | Axor10, a g-protein coupled receptor AXOR10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 03/26/2002 |
| 6358725 | Mouse aspartic secretase-1 (mASP1) Mouse mASP1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mouse mASP1. Such compounds are expec... | 03/19/2002 |
| 6355452 | Human histamine H3 gene variant-2 Human histamine H3 gene variant-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human histamine H3 gene variant-2 polypeptides and polynucleot... | 03/12/2002 |
| 6350446 | HAS2 splicing variant HOEFC11: a target in chronic renal failure, inflammatory diseases and myocardial ischemia HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of... | 02/26/2002 |
| 6342371 | Interleukin-1 homologue, IL-1H4 The IL-1H4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1H4 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 01/29/2002 |
| 6297359 | Protein phosphatase 1 binding protein, R5 Human PPP1R5 polypeptides and DNA (RNA) encoding such PPP1R5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such PPP1R5, or compounds which inhibit or stimulate PPP1R5 for d... | 10/02/2001 |
| 6294364 | Human FAS Fatty Acid Synthase polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising Fatty Acid Synthase polypeptides and polynucleotides in therapy, and diagnos... | 09/25/2001 |
| 6291223 | Mouse aspartic secretase-1 (mASP1) Mouse mASP1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mouse mASP1. Such compounds are expec... | 09/18/2001 |
| 6277977 | cDNA clone HAPOI67 that encodes a human 7-transmembrane receptor HAPOI67 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HAPOI67 polypeptides and polynucleotides in the design of protocols for the treatment of... | 08/21/2001 |
| 6277960 | cDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of... | 08/21/2001 |
| 6274717 | Splicing variant of human membrane-type matrix metalloproteinease-5 (MT-MMP5-L) The MT-MMP5-L polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MT-MMP5-L polypeptides and polynucleotides in therapy, and diagnostic assays for s... | 08/14/2001 |
| 6261819 | Compounds p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 07/17/2001 |
| 6214600 | Membrane-type matrix metalloproteinase-5 gene HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of... | 04/10/2001 |
| 6207803 | Human requiem Human REQUIEM polypeptides and DNA (RNA) encoding such REQUIEM and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such REQUIEM for the treatment of a susceptibility to viral inf... | 03/27/2001 |
| 6200775 | cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor HMTMF81 polypeptides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMTMF81 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as ... | 03/13/2001 |
| 6197931 | Human marco scavenger receptor Human Marco scavenger receptor polypeptides (HMarcoSR) and DNA (RNA) encoding such HMarcoSR and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HMarcoSR for the treatment of... | 03/06/2001 |
| 6174994 | 7TM receptor (H2CAA71) Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides in th... | 01/16/2001 |
| 6169166 | Polynucleotide and polypeptide sequences encoding rat mdr1b2 and screening methods thereof Rat mdr1b2 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rat mdr1b2. Further disclosed is meth... | 01/02/2001 |
| 6165751 | HLDAT86 polynucleotides HLDAT86 (Wnt-4) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLDAT86 (Wnt-4) polypeptides and polynucleotides in the design of protocols for ... | 12/26/2000 |
| 6143521 | Human bombesin receptor subtype-3sb Bombesin receptor subtype-3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Bombesin receptor subtype-3sb polypeptides and polynucleotides in ... | 11/07/2000 |
| 6130067 | Human EDG3sb gene The EDG3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EDG3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 10/10/2000 |
