Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7332610 | Method of preparing amine stereoisomers This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates. ... | 02/19/2008 |
| 7256310 | Levalbuterol salt Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler. ... | 08/14/2007 |
| 7256297 | Methods of preparing sulfinamides and sulfoxides This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared. ... | 08/14/2007 |
| 7220781 | Meta-benzamidine derivatives as serine protease inhibitors Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted... | 05/22/2007 |
| 7157585 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 01/02/2007 |
| 7129378 | Method of preparing amine stereoisomers This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfiny... | 10/31/2006 |
| 7074934 | Serine protease inhibitors Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents. ... | 07/11/2006 |
| 7067516 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 06/27/2006 |
| 7053078 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 05/30/2006 |
| 6936611 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 08/30/2005 |
| 6916957 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 07/12/2005 |
| 6900196 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 05/31/2005 |
| 6878725 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 04/12/2005 |
| 6855715 | Serine protease inhibitors Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents. ... | 02/15/2005 |
| 6784182 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, factor Xa and are useful in the treatment of cardiov... | 08/31/2004 |
| 6740682 | Meta-benzamidine derivatives as serine protease inhibitors The novel compound 3-amidinobenzoyl-D-phenylglycine-3-phenylanilide is useful as a serine protease inhibitor. ... | 05/25/2004 |
| 6656694 | Method for identifying a ligand for a biological substrate A method of identifying a ligand for a second binding site (5) on a biological substrate (1) is disclosed. The method comprises determining the effect of a candidate compound (9) on the binding of a probe compound (2) which binds to a first binding site (... | 12/02/2003 |
| 6419047 | Portable ladder having resistance to slippage A ladder is provided which has considerably reduced tendency to slip. Typically, the ladder 1 has rungs 5 and side members 2 with end caps 3 resting on the ground 4. Securing member 6, made typically from aluminium alloy, has friction member 7 provided wi... | 07/16/2002 |
| 6419045 | Ladders An apparatus is provided for a portable ladder which has essentially parallel side members, the apparatus comprising having a pair of arcuate arms for attachment to the upper end of each side member of the ladder, at least one resilient roller mounted on ... | 07/16/2002 |
| 6414026 | Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease A method of alleviating a fibrotic disease selected from lung fibrosis and liver cirrhosis in a warm blooded animal, which comprises administering an effective amount of at least one compound having the formula (I) ##STR1## in which X stands for the oxyge... | 07/02/2002 |
| 6402143 | Apparatus and method for playing a game A board game apparatus for a game that requires exercise of both judgement and ability to solve problems, simulates a capitalist system and provides players with opportunity to trade off potential reward against risk according to their ability to solve pr... | 06/11/2002 |
| 6348497 | Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease A method of alleviating loosening of prosthetic joints by administering an effective amount of at least one compound having the formula (I) ##STR1## in which X stands for the oxygen or sulphur atom or for the imino (--NH--) or sulphonyl (--SO2 ... | 02/19/2002 |
| 6262069 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors ##STR1## The invention relates to serine protease inhibitor compounds of fornula (I) where R1 is hydrogen, halo, cyano, nitro or hydroxyl, amino, alkoxy, alkyl amminoalkyl, hydroxyalkyl, thiol, alkylthio, aminosulphonyl alkoxyalkyl, alkoxyc... | 07/17/2001 |
| 6245352 | Pharmaceutical formulation The present invention relates to a pharmaceutical formulation, which comprises from 5 to 15% by weight of tamoxifen citrate and a first disintegrant which is croscarmellose sodium, the percentage by weight of croscarmellose sodium present in the formulati... | 06/12/2001 |
| 6160009 | Excitatory amino acid receptor modulators Compounds of the formula ##STR1## in which R1 and R2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.... | 12/12/2000 |
| 6054448 | 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ... | 04/25/2000 |
| 5990165 | Pharmaceutical compounds A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally ... | 11/23/1999 |
| 5986114 | Benzopyranol derivatives The invention relates to benzopyranol derivatives which are intermediates in a process for stereoselectively forming N-substituted dihydro-2,3 benzodiazopines which are useful as AMPA receptor antagonists. The process includes an opening reduction step wh... | 11/16/1999 |
| 5925782 | Synthetic excitatory amino acids The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.... | 07/20/1999 |
| 5925680 | Synthetic excitatory amino acids The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.... | 07/20/1999 |
| 5919954 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to ... | 07/06/1999 |
| 5916920 | 3-substituted Bicyclo3.1.0!hexane-6-carboxylic acids Compounds of the formula ##STR1## in which X represents a bond, S, O or NRa ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.... | 06/29/1999 |
| 5912248 | Excitatory amino acid receptor antagonists Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.... | 06/15/1999 |
| 5906985 | Pharmaceutical compounds Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R1 is hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, phenyl, naphthyl, C1-10 alkyl-phenyl, C2-... | 05/25/1999 |
| 5891899 | Pharmaceutical xanthene compounds A pharmaceutical compound of the formula: ##STR1## in which A is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OPO(OH)OR' B is a bond, C1-6 alkylene or C2-6 ... | 04/06/1999 |
| 5665878 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to ... | 09/09/1997 |
| 5641798 | Bicyclic compounds and their use as excitatory amino acid receptor antagonists This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides intermediates useful in the synthesis of excitatory amino acid ant... | 06/24/1997 |
| 5591867 | Synthesis of kainic acid This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.... | 01/07/1997 |
| 5441984 | Urea, thiourea and guanidine derivatives The present invention provides novel urea, thiourea and guanidine derivatives, pharmaceutical formulations thereof and a method of using same to prevent diabetic complications.... | 08/15/1995 |
