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| Number | Title | Issue Date |
| 7390931 | Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. Wh... | 06/24/2008 |
| 7250433 | Tetrazole and oxadiazolone substituted β-amino acid derivatives This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula wherein G is wherein R1 through R4 | 07/31/2007 |
| 7230135 | Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described. ... | 06/12/2007 |
| 7101886 | Phenylalkyl and pyridylalkyl piperazine derivatives This invention relates to compounds of the formula 1 wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containi... | 09/05/2006 |
| 7071339 | Process for preparing functionalized γ-butyrolactones from mucohalic acid A process for preparing functionalized γ-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meaning... | 07/04/2006 |
| 7018818 | Intermediates in the preparation of therapeutic fused bicyclic amino acids The invention presents compounds of formula (I), where R represents H or a suitable carboxylic acid protecting group, which are intermediates in the preparation of therapeutic fused bicyclic amino acids. ... | 03/28/2006 |
| 7001917 | Pyrazole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 | 02/21/2006 |
| 6956050 | Imidazole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 | 10/18/2005 |
| 6932961 | Oxazinocarbazoles for the treatment of CNS diseases The present invention provides isotopically labeled oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R1, R2, R3 and R4 ... | 08/23/2005 |
| 6924377 | Process for preparing highly functionalized γ-butyrolactams and γ-amino acids The invention relates to a process for preparing highly functionalized γ-butyrolactams and γ-amino acids by reductive amination of mucohalic acid or its derivatives, and discloses a process for preparing pregabalin, a GABA analog with desirable medicinal activity.... | 08/02/2005 |
| 6919377 | Cyclohexylamine derivative as subtype selective NMDA receptor antagonists Described are compounds of Formula I and Formula II and their pharmaceutically acceptable salts. The compounds of Formulas I and II are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral isch... | 07/19/2005 |
| 6911555 | Cyclic nitromethyl acetic acid derivatives The invention provides salts of formula (I) wherein X is a basic counterion selected from a group I or group II metal and a primary, secondary or tertiary amine; n is 0, 1 or 2; and R1 | 06/28/2005 |
| 6869960 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor A compound of the formula: or a pharmaceutically acceptable salt, ester or ether thereof, wherein R1 through R12 are independently hydrogen or the like; X1 and X2 are indepen... | 03/22/2005 |
| 6846953 | Aromatic amides Aromatic and heteroaromatic amides of the formula where R1, R2 and R3 can be alkyl, X is alkylene, and R4 is an unsubstituted or substituted aromatic or heteroaromatic group ... | 01/25/2005 |
| 6828341 | Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists Described are cyclohexylamine derivatives of Formula I and pharmaceutically acceptable salts thereof, wherein R1, g, *, R, V, B, E, Y, G, H, X1, and d are as defined in the description. The compou... | 12/07/2004 |
| 6821963 | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical,... | 11/23/2004 |
| 6696440 | Treatment of asthma with MEK inhibitors This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II: ##STR1##... | 02/24/2004 |
| 6245802 | Method for treating pain The present invention provides a method for treating pain comprising administering to a mammal an analgesic composition comprising duloxetine and one or more NSAIDs or acetaminophen.... | 06/12/2001 |
| 6201127 | Process for preparing benzyl-substituted rhodanine derivatives The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. Also provided are novel benzyl-substituted thiolamides and benzyl-substituted hemithioacetals. Such compounds are useful as intermediates in preparing t... | 03/13/2001 |
