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...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
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| Number | Title | Issue Date |
| 8163718 | Nucleoside analogues containing phosphonate or phosphonamide groups Novel compounds having structure (1) wherein Z, is N or CH to form a purine, Y, R1, R2′ and R2 are defined in the specification, are provided for use in the treatment of tumors and ... | 04/24/2012 |
| 8158810 | ALDH-2 inhibitors in the treatment of addiction Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing age... | 04/17/2012 |
| 8148376 | 3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors The present invention discloses 3,4-dihydroquinoxalin-2(1H)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases r... | 04/03/2012 |
| 8134000 | Imidazolyl pyrimidine inhibitor compounds A compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. | 03/13/2012 |
| 8124764 | Fused heterocyclyc inhibitor compounds The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compoun... | 02/28/2012 |
| 8093226 | Cytostatic 7-deazapurine nucleosides The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic... | 01/10/2012 |
| 8088792 | Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human disease... | 01/03/2012 |
| 8088771 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. | 01/03/2012 |
| 8088754 | Anti-proliferative compounds, compositions, and methods of use thereof Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1... | 01/03/2012 |
| 7795269 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, ca... | 09/14/2010 |
| 7795268 | Method of treating hepatic disease using Aadenosine receptor antagonists The invention is related to methods of treating hepatic fibrosis using A2B adenosine receptor antagonists and utility in the treatment of liver damage caused by alcohol abuse, surgical intervention, viral hepatitis, the ingestion of hepatotoxic drugs, or ... | 09/14/2010 |
| 7776868 | Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as Aadenosine receptor antagonists The present invention relates to novel compounds that are A2A adenosine receptor antagonists having the structure of Formula I and to their use in treating mammals for various disease states, such as obesity, CNS... | 08/17/2010 |
| 7741331 | A2B adenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, ca... | 06/22/2010 |
| 7732453 | Pyrido[2,3-B] pyrazin-3(4H)-ones for use as stearoyl CoA desaturase inhibitors The present invention discloses pyrido[2,3-B]pyrazin-3(4h)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases re... | 06/08/2010 |
| 7713946 | Partial and full agonists Aadenosine receptors Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin ... | 05/11/2010 |
| 7696181 | Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. The structure of the compou... | 04/13/2010 |
| 7662819 | Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediat... | 02/16/2010 |
| 7625881 | Prodrugs of Aadenosine receptor antagonists Disclosed are prodrugs of A2B adenosine receptor antagonists, having the following structure and their use in treating mammals for various disease states. ... | 12/01/2009 |
| 7601721 | Substituted heterocyclic compounds Disclosed are novel piperazine and piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, diabetes, intermittent claudication, Prinzmetal's (variant) angina, stabl... | 10/13/2009 |
| 7579504 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 08/25/2009 |
| 7566717 | Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent cl... | 07/28/2009 |
| 7521554 | Aadenosine receptor antagonists Disclosed are processes for the synthesis of novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea. ... | 04/21/2009 |
| 7517888 | Aadenosine receptor antagonists Disclosed are A1 adenosine receptor antagonists having the general formula The compounds are useful for treating various disease states, in particular disease states for which diuretic treatment is appropriate.... | 04/14/2009 |
| 7514417 | A adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial... | 04/07/2009 |
| 7449473 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as Aadenosine receptor antagonists Disclosed are novel compounds that are A2B adenosine receptor antagonists having the following structure: wherein R1 and R2 are independently chosen from hydrogen, optionally substituted alk... | 11/11/2008 |
| 7432276 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 10/07/2008 |
| 7423045 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 09/09/2008 |
| 7381714 | A1 adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial... | 06/03/2008 |
| 7317017 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract dis... | 01/08/2008 |
| 7304070 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract di... | 12/04/2007 |
| 7300923 | Partial and full agonists of A1 adenosine receptors Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infa... | 11/27/2007 |
| 7271169 | Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, inte... | 09/18/2007 |
| 7271157 | Aadenosine receptor agonists Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonist having the structure of Formula I: wherein R is optionally subst... | 09/18/2007 |
| 7262198 | Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri... | 08/28/2007 |
| 7262176 | Adenosine A receptor agonists Disclosed are novel compounds that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia. ... | 08/28/2007 |
| 7238700 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is... | 07/03/2007 |
| 7208496 | Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, inte... | 04/24/2007 |
| 7205303 | Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, m particular cardiovascular diseases such as atrial and ventricular arrhythmias, inter... | 04/17/2007 |
| 7189730 | Aadenosine receptor antagonists Disclosed are novel A2A adenosine receptor antagonists of the formula: wherein: R1 is optionally substituted aryl or optionally substituted heteroaryl; | 03/13/2007 |
| 7163928 | Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ... | 01/16/2007 |
