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Attorney: Harbour; John W.


Number of patents: 57
Last date: October 30, 2007

1    
NumberTitleIssue Date
7288540Phenylalkynes
Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4
10/30/2007
6573267Useful aroyl aminoacyl pyrrole compounds
This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to,...
06/03/2003
6521655Substituted imidazoles useful in the treatment of inflammatory diseases
This invention relates to a series of substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory c...
02/18/2003
6492387Isoindolyl and isoquinolinyl aroyl pyrrole compounds
This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders....
12/10/2002
6426356Imidazoethyl thiophenes
Certain imidazoethyl thiophenes/thiazoles and benzothiophenes of the formula: ##STR1## where Z is CH or N; and X is independently selected from the group consisting of hydrogen, C1-4 alkyl, bromine, chlorine, iodide, trifluoromethyl, C4-1
07/30/2002
6067749Papaver somniferum strain with high concentration of thebaine and oripavine
There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination...
05/30/2000
5641757Stable 2-chloro-2'-deoxyadenosine formulations
Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol, m-cresol, a buffer and sodium chloride or a solubilizing agent such as propylene glycol or polyethylene glycol....
06/24/1997
56211134-[(thien-2-yl)methyl]-imidazole analgesics
The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl, X is hydrogen, C1-4 alkyl, bromine or chlorine, and Y is hydrogen, C1-4 alkyl, bromine or chlorine; with the proviso that X and Y are not bot...
04/15/1997
5601092Method for making thin walled closed ended tubular articles of thermoplastic elastomers
A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is...
02/11/1997
5565456Anxiolytic aroyl piperidinyl and piperazinylacyl pyrroles
Aroyl(piperidinyl and piperazinyl)acyl pyrroles of the following formula have anxiolytic activity: ##STR1## wherein, Y is selected from the group consisting of N, CH or COH; A1 is selected from the group consisting of ##STR2## n is a...
10/15/1996
55435304-arylisoindole analgesics
The 4-arylisoindoles of the following formula are effective analgesics: ##STR1## including the purified stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## Rb is hydroxy or C1-5 alkylcarbonyloxy....
08/06/1996
5458936Polyesterurethane condom
A condom of thermoplastic elastomer is drawn from a polyesterurethane....
10/17/1995
5457212Process for the preparation of enantiomerically pure thienopyran derivatives
A process for the preparation of enantiomerically pure thienopyran derivatives of the formula ##STR1## is described. The thienopyran derivatives are relaxants of smooth muscle tone and as such are useful in vascular tissue for the treatment of h...
10/10/1995
53876021.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
1,5-Diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals....
02/07/1995
5382666Heterocyclic intermediates
Biphenylyl tetrazoles for treating hypertension in mammals of the formula: ##STR1## where X is CH2, O, S, N--R4, NH, NCHO, NCOCH3 or NCO2 R4 ; R1 and R2 are the same or different...
01/17/1995
5256658Angiotensin II inhibitors
Biphenylyl tetrazoles for treating hypertension in mammals of the formula: ##STR1## where X is CH2, O, S, N--R4, NH, NCHO, NCOCH3 or NCO2 R4 ; R1 and R2 are the same or different...
10/26/1993
4933414Radiation active silicon compounds having amide limited mercaptan functional groups
Mercaptan substituted silicon compounds are produced by the reaction of amine with carboxyl. UV curable silicon compositions are produced from such compounds....
06/12/1990
4897459Catalyst for producing fluorosilicone polymers
Sodium fluorosilanolate catalyst is disclosed which has improved effectiveness as a catalyst to produce fluorosilicone polymer and which at the same time improves fluorosilicone polymer purity....
01/30/1990
4888384Stable, two package water emulsions of silicone hydride fluids
An emulsion where water is a continuous phase and having a discontinuous oil phase comprising: (a) silicone hydrides containing units of the formula: Ra Hb SiO.sub.(4-a-b)/2 where a may be 0, 1, or 2; b may be 1 or 2; a+b may be 1, 2, or 3; R...
12/19/1989
4868157Dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives as host resistance enhancers in AIDS-immunocompromised hosts and methods of use
Disclosed are specific dipeptidyl 2-amino-1,2-dideoxy-D-glucoses which, either alone, or in combintion with an anti-AIDS drug, e.g. azidothymidine, protect an immunocompromised human host, resulting from an AIDS-related virus, against opportunistic, bacte...
09/19/1989
4868155Dipeptidyl 4-0-,6-0-acyl-2-amino-2-deoxy-D-glucose compositions and methods of use in AIDS-immunocompromised human hosts
Disclosed are specific dipeptidyl 4-0, 6-0-acyl-2-amino-2-deoxy-D-glucose derivatives which, either alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, protect against opportunistic bacterial, fungal and viral infection in a human host i...
09/19/1989
4866035Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
Disclosed are specific dipeptidyl saccharide derivatives which alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, provide protection against opportunistic infection in human individuals whose resistance to infection has been specificall...
09/12/1989
4866036Dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose compositions and methods of use in aids-immunocompromised human hosts
Disclosed are specific dipeptidyl 5-0, 6-0-Acyl-2-amino-2-deoxy-D-glucofuranoses, which, either alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, provide protection in human individuals whose resistance to infection has been speci...
09/12/1989
4833190Zinc borate as a smoke suppressant
Zinc borate is added to high hydrocarbon content silicone containing compositions to reduce smoke emission....
05/23/1989
4808634Low density silicon foam
Ketoxime compounds are added to foamable elastomeric silicone foam contain organic alcohol as a hydroxyl source to reduce foam density....
02/28/1989
4800127Thermal shock resistant silicone coating composition
Thermal shock resistant silicone coating formulations are disclosed to contain polydiorganosiloxane fluid, silicone resin and mica....
01/24/1989
4764560Interpenetrating polymeric network comprising polytetrafluoroethylene and polysiloxane
There is provided a composition having interpenetrating matrices comprising (a) a first polymer network characterized by nodes interconnected by fibrils and (b) a second polymer network comprising diorganosiloxy units. In another aspect, there are provide...
08/16/1988
4762859Low density silicone foam
Treated filler having surface nitrogen groups is added to silicone foam to reduce density....
08/09/1988
4758646Curable hydrophilic silicone polyether polymer
A bis (alkoxysilyl) polyether is produced and utilized as a fabric sizing agent....
07/19/1988
4755370Purification of silicon halides
A method for the selective removal of boron halides and other Lewis acid-type impurities from silicon halides is disclosed. Treatment of contaminated silicon halides with siloxanes, which react with the impurities, allow the distillation of silicon halide...
07/05/1988
4728450Torque grease
A torque grease comprising: (A) 100 parts by weight of a polyorganosiloxane represented by the general formula: ##EQU1## wherein R1 is a C.sub.(1-12) monovalent radical selected from the group consisting of alkyl radicals, alkenyl radicals...
03/01/1988
4728687Silicone elastomer composition
A vulcanizable silicone elastomer composition which has novel crosslinking points comprises (A) 100 parts by weight of a polyorganosiloxane having a polymerization degree of at least 100, wherein the organic groups are selected from monovalent substituted...
03/01/1988
4728567Silicone foam backed polyimide film
There is disclosed a plastic film or metal foil composite sheet containing: (a) a first layer of plastic film or metal foil having firmly adhered to at least one side thereof, (b) a second layer of silicone foam....
03/01/1988
4725648Polyorganosiloxane composition
The present invention relates to a polyorganosiloxane composition and, more particularly, to a polyorganosiloxane composition having good curing properties at room temperature and producing cured materials having good water absorption properties. The poly...
02/16/1988
4725658Novel silicone-ester waxes
There are provided novel silicone-ester waxes having the general unit formula ##EQU1## where R is hydrogen or an organic radical, R1 is an ester-containing radical having at least 12 carbon atoms, a and b are independently selected in...
02/16/1988
4724167Treated silica fillers and process for making the same
A treatment for finely divided silica reinforcing fillers is provided which utilizes low temperature and hydroxy or alkoxy containing diorganopolysiloxane as the treating agent. The treatment of fillers in this manner facilitates the manufacture and incor...
02/09/1988
4705704Novel aminofunctional polysiloxane emulsions for treating textiles
There are provided substantially trialkylsiloxy terminated polysiloxanes having at least one amino or substituted amino group linked to at least one trifunctional siloxy unit of said polysiloxane through an alkylene or arylene bridge. Emulsions of such po...
11/10/1987
4689248Silicone coated optical fibers
The present invention provides curable silicone compositions, comprising: (a) a substantially linear olefinic group-containing polydiorganosiloxane; (b) a resinous olefinic group-containing polysiloxane; (c) a reactive organic monomer; (d) an organohydrogenpolysiloxane,...
08/25/1987
4681913Method for preventing premature curing of silicone compositions and compositions made thereby
There is provided a method for preventing premature curing of curable silicone compositions comprising admixing with said curable composition an amount of Lewis base effective to neutralize any Lewis acid present therein....
07/21/1987
4680364Room temperature vulcanizable silicone compositions having improved adhesion
There is provided a room temperature vulcanizable silicone rubber composition which upon curing to the solid, elastic state exhibits improved adhesion to various substrates, comprising: (a) a polydiorganosiloxane wherein the silicon atom at each polymer chain ...
07/14/1987
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