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| Number | Title | Issue Date |
| 7915420 | Aryl piperidine amides The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic... | 03/29/2011 |
| 7576105 | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators. ... | 08/18/2009 |
| 7504426 | Heterocyclic compounds Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis. ... | 03/17/2009 |
| 7504414 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 03/17/2009 |
| 7498343 | Mycobacterial inhibitors The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemi... | 03/03/2009 |
| 7482364 | Phenylalkynes Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 01/27/2009 |
| 7456208 | CCK-1 receptor modulators Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. ... | 11/25/2008 |
| 7446104 | Phenylalkynes Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 11/04/2008 |
| 7358261 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alky... | 04/15/2008 |
| 7276610 | Aryl piperidine amides The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic... | 10/02/2007 |
| 7271261 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 09/18/2007 |
| 7250434 | CCK-1 receptor modulators Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. ... | 07/31/2007 |
| 7250427 | Aryl-substituted benzimidazole and imidazopyridine ethers Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 07/31/2007 |
| 7241759 | Benzo[1,2,5]thiadiazole compounds Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases. ... | 07/10/2007 |
| 7202269 | GlyT2 modulators Certain α-, β-, and γ-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. ... | 04/10/2007 |
| 7179818 | Substituted aminoquinuclidine compounds This invention is directed towards substituted aminoquinuclidine compounds useful as delta-opioid receptor modulators, delta-opioid receptor agonists useful as analgesics and delta-opioid receptor antagonists useful as immunosuppressants, antiinflammatory agents, ag... | 02/20/2007 |
| 7179808 | Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders This invention is directed to substituted heteroaryl and heterocyclic compounds as nicotinamide adenine dinucleotide oxidase hydride donor inhibitors useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder. ... | 02/20/2007 |
| 7071191 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/04/2006 |
| 6888001 | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of t... | 05/03/2005 |
| 6884803 | Phenylalkynes Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and us... | 04/26/2005 |
| 6436959 | 4-[aryl(piperidin-4-yl)]aminobenzamides 4-[aryl(piperidin-4-yl)]aminobenzamides are delta-opioid receptor agonists/antagonists. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful immunosuppr... | 08/20/2002 |
| 6376221 | Production of thebaine and oripavine There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination... | 04/23/2002 |
| 6369228 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.... | 04/09/2002 |
| 6313309 | 4-thionaphthyl--1H--imidazoles which are useful-adrenoceptoR agonists/ antagonists 4-thionaphthyl-1H-imidazoles are 댒 -adrenoceptor agonists/antagonists. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful agents to ... | 11/06/2001 |
| 6306876 | 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives 4-[aryl(8-azabicyclo[3.2.1]octan-3yl)]aminobenzoic acid derivatives are delta-opioid receptor modulators. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their antagonist effect, such compounds may also be useful i... | 10/23/2001 |
| 6213123 | Method for making thin walled, closed-ended, tubular articles of thermoplastic elastomer A process for drawing, with plug assist, thin walled, closed-ended, tubular articles of thermoplastic elastomer is disclosed as well as a thermoplastic elastomer and apparatus therefor. According to the process, a plug, extensible into the mold cavity, is... | 04/10/2001 |
| 6214815 | Triphasic oral contraceptive A method of contraception in which an estrogen and a progestogen are administered daily in a three phase sequence for 21 days is disclosed. In the first phase a combination of an estrogen and a progestogen in a low but contraceptively effective daily dosa... | 04/10/2001 |
| 6063803 | Octahydropyrrolo-[3,4-c]carbazoles useful as analgesic agents This invention relates to a series of compounds of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. Compounds of the invention alleviate pain in animal models at levels comparable to known an... | 05/16/2000 |
| 6040320 | 2-substituted imidazoles useful in the treatment of inflammatory diseases This invention relates to substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them, methods of using them and intermediates useful in their manufacture. The compounds of the invention modulate the production of a numbe... | 03/21/2000 |
| 5965583 | Substituted imidazoles useful in the treatment of inflammatory disease This invention relates to a series of substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammat... | 10/12/1999 |
| 5681822 | Soluble 2-chloro-2'-deoxyadenosine formulations Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol and, optionally, propylene glycol.... | 10/28/1997 |
| 5508424 | 4-arylisoindole analgesics The 4-arylisoindoles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso that there is 0 or 1 unsaturated bond in the isoindole ... | 04/16/1996 |
| 5418236 | Anxiolytic aroyl piperidinyl and piperazinylacyl pyrroles Aroyl(piperidinyl and piperazinyl)acyl pyrroles of the following formula have anxiolytic activity: ##STR1## wherein, Y is selected from the group consisting of N, CH or COH; A1 is selected from the group consisting of ##STR2## n is an... | 05/23/1995 |
| 5284857 | Substituted thienopyrans as antihypertensive agents Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.... | 02/08/1994 |
| 5260453 | Substituted thienopyrans as antihypertensive agents Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents... | 11/09/1993 |
