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| Number | Title | Issue Date |
| 8178347 | Gene regulatory networks and methods of interdiction for controlling the differentiation state of a cell The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor ... | 05/15/2012 |
| 8158595 | Modular aptamer-regulated ribozymes An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is provided. These switch platforms typically contain a sensor domain, c... | 04/17/2012 |
| 8147866 | Transmucosal delivery devices with enhanced uptake The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament.... | 04/03/2012 |
| 8147825 | Topical co-enzyme Q10 formulations and methods of use Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing an... | 04/03/2012 |
| 8124616 | Bicyclic PPAT inhibitors as antibacterial agents Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and preventio... | 02/28/2012 |
| 8119630 | Benzodiazepine derivatives and pharmaceutical compositions containing them Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV Formula (I) Wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 ... | 02/21/2012 |
| 8093045 | Fed-batch cell culture methods using non-animal-based hydrolysates The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and com... | 01/10/2012 |
| 8048350 | Structural hydrogel polymer device The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical... | 11/01/2011 |
| 8044199 | N-formyl hydroxylamines compounds Novel N-formyl hydroxylamine compounds of formula I: wherein R1 is hydrogen, alkyl, heteroaryl, heterocycloalkyl, aryl, heteroaryl or cycloalkyl; R3 is hydrogen, halogen or a... | 10/25/2011 |
| 8039221 | Methods for identifying and using MarR family polypeptide binding compounds Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides. ... | 10/18/2011 |
| 7977330 | Salts and crystal modifications thereof The invention relates to salts of 1-(2-Fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea and crystalline forms thereof, their production and usage, and pharmaceutical preparations containing such salts and crystalline forms. ... | 07/12/2011 |
| 7947453 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 05/24/2011 |
| 7923598 | Fatty acid hydroxylases and uses thereof The invention provides isolated nucleic acid molecules which encode novel fatty acid hydroxylases. The invention also provides recombinant expression vectors including hydroxylase nucleic acid molecules, host cells into which the expression vectors have been introdu... | 04/12/2011 |
| 7910301 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 03/22/2011 |
| 7863426 | Antibody purification The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange mater... | 01/04/2011 |
| 7807420 | Method for recovering a basic amino acid from a fermentation liquor The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor... | 10/05/2010 |
| 7785779 | P EF-TU expression units The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, ... | 08/31/2010 |
| 7691819 | Modulation of cell fates and activities by phthalazinediones Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survi... | 04/06/2010 |
| 7682784 | Methods for drug discovery disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 03/23/2010 |
| 7682783 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 03/23/2010 |
| 7635556 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 12/22/2009 |
| 7615635 | N-formyl hydroxylamines Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the ... | 11/10/2009 |
| 7612059 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 11/03/2009 |
| 7588761 | Human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα d... | 09/15/2009 |
| 7585976 | Hemiasterlin derivatives and uses thereof The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1 | 09/08/2009 |
| 7582624 | Benzodiazepine derivatives and pharmaceutical compositions containing them Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV. Formula (I) Wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6... | 09/01/2009 |
| 7566815 | Control of plant flowering time by regulation of phytochrome c expression Rice phyC mutants were isolated using a mutant panel isolation method. When the mutants were grown under long-day photoperiodic conditions, it was found that they flowered (exposed their panicles (heads)) about one week earlier than the control rice. The results ind... | 07/28/2009 |
| 7553828 | 9-aminomethyl substituted minocycline compounds The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 06/30/2009 |
| 7553616 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 06/30/2009 |
| 7550260 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 06/23/2009 |
| 7550258 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 06/23/2009 |
| 7541031 | Methods for treating rheumatoid arthritis using human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα d... | 06/02/2009 |
| 7521050 | Human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα d... | 04/21/2009 |
| 7504485 | Human antibodies that bind human IL-12 Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can... | 03/17/2009 |
| 7501255 | Levels of Pin1 in normal and cancerous tissue Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. The levels of Pin1 can be p... | 03/10/2009 |
| 7414076 | Methods and compositions for treating amyloid-related diseases Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease. ... | 08/19/2008 |
| 7405235 | Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reduci... | 07/29/2008 |
| 7329489 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/12/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7323492 | 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to thr... | 01/29/2008 |
