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| Number | Title | Issue Date |
| 8173602 | Detecting CYP24 expression level as a marker for predisposition to cancer This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides m... | 05/08/2012 |
| 8101370 | Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ... | 01/24/2012 |
| 8093020 | Allelic discrimination analysis using an efficiency related value (EFR) In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target... | 01/10/2012 |
| 8021837 | Detection of chromosomal abnormalities associated with breast cancer Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 09/20/2011 |
| 7741104 | Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample throug... | 06/22/2010 |
| 7648826 | Detecting expression level as a marker for predisposition to cancer This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides m... | 01/19/2010 |
| 7608270 | Dosage form A pharmaceutical or dietetic dosage form comprising of effective quantity of an active substance chemically or physically bound to a support comprising sporopollenin, or other similar exine coating of spores, of a plant or fungus, optionally with further excipients.... | 10/27/2009 |
| 7595175 | Polyketides and their synthesis Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or... | 09/29/2009 |
| 7563583 | Heregulin variants The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-β1 having enhanced affinity for the ErbB-3 and ErbB-4 recepto... | 07/21/2009 |
| 7537895 | Comparative genomic hybridization Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 05/26/2009 |
| 7534567 | Detection of nucleic acid sequence differences by comparative genomic hybridization The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits... | 05/19/2009 |
| 7455964 | Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ... | 11/25/2008 |
| 7413899 | Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ... | 08/19/2008 |
| 7408023 | Peptoids incorporating chemoselective functionalities Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made e... | 08/05/2008 |
| 7264817 | Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it Disclosed is an invention related to the preparation and use of vaccines against pathogenic organisms, such as herpes virus. The vaccines hereof are based upon the use of truncated, membrane-free derivatives of a membrane-bound polypeptide from the pathogen. These p... | 09/04/2007 |
| 7238784 | Rh antibody Rh antibody hybrids for use in testing red blood cells for the presence of one or more Rh factors. The Rh hybrid antibody may also be used in therapeutic procedures which require the use of Rh antisera. The hybrid antibody includes an IgG anti-Rh antibody which has ... | 07/03/2007 |
| 7238484 | Comparative genomic hybridization Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 07/03/2007 |
| 7094534 | Detection of chromosoal abnormalities associated with breast cancer Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 08/22/2006 |
| 7071322 | HIV envelope polynucleotides and immunogenic composition Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together ... | 07/04/2006 |
| 7045513 | DHEA composition and method Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation comprises, in solid form, DHEA, at least 85% of which is present as ... | 05/16/2006 |
| 7041293 | HIV env antibodies The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in vitro. ... | 05/09/2006 |
| 6989237 | Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample throug... | 01/24/2006 |
| 6962971 | Chemokines and methods for inducing the differentiation of fibroblasts to myofibroblasts This invention is based on the discovery that chemokines induce fibroblasts to differentiate to myofibroblasts, which play a critical role in wound healing and are implicated in a number of fibrotic diseases. This activity has been localized to a peptide in the N-te... | 11/08/2005 |
| 6913767 | Compositions for microencapsulation of antigens for use as vaccines Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with an... | 07/05/2005 |
| 6854468 | Treatment of subnormal bone mineral density A method of treating an individual to increase the individual's bone mineral density (BMD) is disclosed. The method includes co-administering a calcitonin-like agent and a DHEA-like agent. Also disclosed are methods for potentiating the effect of treatment with a ca... | 02/15/2005 |
| 6818184 | Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample throug... | 11/16/2004 |
| 6806055 | HIV envelopolype peptides A method for the rational design and preparation of vaccines based on HIV envelope polypeptides is described. In one embodiment, the method for making an HIV gp120 subunit vaccine for a geographic region comprises determining neutralizing epitopes in the V2 and/or C... | 10/19/2004 |
| 6716592 | Materials and methods relating to the diagnosis and treatment of diabetes and obesity The diagnosis of diabetes based on the level or ratio of P- and A-type inositolphosphoglycans (IPGs) in a sample from a patient is disclosed. ... | 04/06/2004 |
| 6686334 | Use of inhibitors of protein kinase C epsilon to treat pain The role of the &3xb5; isozyme of protein kinase C ("PKC&3xb5;") in pain perception, particularly hyperalgesia, methods of lessening pain through administration of inhibitors of PKC&3xb5;, methods of identifying compounds that modulate pain, and pharmaceu... | 02/03/2004 |
| 6610499 | Capillary array and related methods The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sa... | 08/26/2003 |
| 6605591 | Treatment of subnormal bone mineral density A method of treating an individual to increase the individual's bone mineral density (BMD) is disclosed. The method includes co-administering a calcitonin-like agent and a DHEA-like agent. Also disclosed are methods for potentiating the effect of treatmen... | 08/12/2003 |
| 6585979 | HIV envelope polypeptides and immunogenic composition Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usuall... | 07/01/2003 |
| 6552010 | Treatment of SLE with dehydroepiandrosterone This invention provides a method of treating systemic lupus erythematosus (SLE) with (DHEA) and a related pharmaceutical product.... | 04/22/2003 |
| 6534285 | Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use Diagnostic product and vaccine for Acquired Immuno-deficiency Syndrome (AIDS) and methods for making and using same, wherein viral polypeptide sequences from an AIDS associated retrovirus are expressed directly or as a fusion polypeptide in a prokaryotic ... | 03/18/2003 |
| 6495330 | Materials and methods relating to the diagnosis and treatment of pre-eclampsia and diabetes The present invention relates to materials and methods for the diagnosis and treatment of pre-eclampsia, and more particularly to the role of P-type inositolphosphoglycans (IPGs) in the occurrence of pre-eclampsia. Methods of diagnosing pre-eclampsia by d... | 12/17/2002 |
| 6417506 | High density array fabrication and readout method for a fiber optic biosensor The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding comple... | 07/09/2002 |
| 6387638 | Heregulin variants The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-댡 having enhanced affinity for the ErbB-3 an... | 05/14/2002 |
| 6335167 | Comparative genomic hybridization (CGH) Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substant... | 01/01/2002 |
| 6331404 | HIV envelope polypeptides A method for the rational design and preparation of vaccines based on HIV envelope polypeptides is described. In one embodiment, the method for making an HIV gp120 subunit vaccine for a geographic region comprises determining neutralizing epitopes in the ... | 12/18/2001 |
| 6271204 | Cyclitol containing carbohydrates from human tissue which regulate glycogen metabolism The present invention provides for an isolated P-type substance having a structure identical to a P-type substance obtained from human liver or placenta, which is a cyclitol containing carbohydrate comprising Mn2+ and Zn2+ and relate... | 08/07/2001 |
