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| Number | Title | Issue Date |
| 8377878 | Therapies for chronic renal failure The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certa... | 02/19/2013 |
| 8372805 | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 02/12/2013 |
| 8354376 | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 01/15/2013 |
| 8354375 | Repair of ligament using osteogenic proteins Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra... | 01/15/2013 |
| 8318467 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ... | 11/27/2012 |
| 8288400 | Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositi... | 10/16/2012 |
| 8247402 | Crystal form of pyrrolidylthiocarbapenem derivative Novel crystals of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3[[(3S,5S)-5-(sulfamoylaminomethyl)p yrrolidin-3-yl]thio]-1-azabicy... | 08/21/2012 |
| 8217048 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents.... | 07/10/2012 |
| 8211696 | Method useful for HCV RNA898 infection The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present i... | 07/03/2012 |
| 8192972 | Crystal structure of human JAK3 kinase domain complex and binding pockets thereof The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to meth... | 06/05/2012 |
| 8168190 | HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct... | 05/01/2012 |
| 8158578 | Methods for treating neurological deficits The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) wi... | 04/17/2012 |
| 8138143 | Methods for treating a neurological disorder by peripheral administration of a trophic factor The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor c... | 03/20/2012 |
| 8124392 | Crystal structure of Aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 02/28/2012 |
| 8119631 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 02/21/2012 |
| 8071295 | DNA-based methods of geochemical prospecting The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analyses of a population. The invention further relates to methods for the creation of databases co... | 12/06/2011 |
| 8067388 | Decoy-containing pharmaceutical compositions and method of using the same A pharmaceutical composition is provided for treatment and prevention of a disease caused by expression of a gene controlled by NF-κB or ets. The composition comprises at least one decoy and a pharmaceutically acceptable carrier. The decoy is an NF-κB decoy, an et... | 11/29/2011 |
| 8067224 | Presenilin associated membrane protein (PAMP) and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 11/29/2011 |
| RE42954 | Method for repairing a defect in an intervertebral disc Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra... | 11/22/2011 |
| 8017619 | Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositi... | 09/13/2011 |
| 8002891 | Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets. ... | 08/23/2011 |
| 7989498 | Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e... | 08/02/2011 |
| 7972813 | Tetrodotoxin-resistant sodium channel alpha subunit The present invention is directed to a chimp sodium channel alpha subunit and methods and compositions for making and using the same. ... | 07/05/2011 |
| 7960398 | Regulation of TNF-alpha The present invention relates to methods for identifying compounds useful for regulating TNF-alpha levels and/or activity. The invention also relates to methods for decreasing TNF-alpha levels and/or activity. Compounds and compositions according to this invention a... | 06/14/2011 |
| RE42461 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4-substituted aryl; | 06/14/2011 |
| 7919523 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 04/05/2011 |
| 7919079 | Cancer immunotherapy compositions and methods of use Cellular compositions and methods for inducing an immune response to tumor cells are described. The cellular compositions include a tumor antigen and cells that have been modified to express a cytokine and one or more of a tumor antigen, anti-CTLA4 antibody and an a... | 04/05/2011 |
| 7888065 | Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid ... | 02/15/2011 |
| 7883881 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ... | 02/08/2011 |
| 7846679 | Methods for detecting the presence of mutant mammalian presenilin protein The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 12/07/2010 |
| 7879606 | Compositions and methods useful for HCV infection The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present i... | 02/01/2011 |
| 7858083 | Pan cancer oncolytic vectors and methods of use thereof Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replica... | 12/28/2010 |
| 7838247 | Antibody specific for mutant presenilin 2 and method of use thereof The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 11/23/2010 |
| 7823591 | Female barrier contraceptive with vacuum anchoring A female condom has a pouch with an open end, a closed end, and a tubular body extending longitudinally therebetween. The female condom also includes an anchor attached to and outside of the closed end of the pouch. ... | 11/02/2010 |
| 7809541 | Crystal structure of aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 10/05/2010 |
| 7807659 | Caspase inhibitors and uses thereof The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this inventio... | 10/05/2010 |
| 7803369 | Devices and method for repair of larynx, trachea, and other fibrocartilaginous tissues Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra... | 09/28/2010 |
| 7795202 | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor c... | 09/14/2010 |
| 7790713 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 09/07/2010 |
| 7790669 | Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α) The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) wi... | 09/07/2010 |
