Haley, Jr.; James F. - US Patent Attorneys and Agents

Attorney: Haley, Jr.; James F.

Number of patents: 238
Last date: May 01, 2012

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Number	Title	Issue Date
8168190	HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct...	05/01/2012
8158578	Methods for treating neurological deficits The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) wi...	04/17/2012
8138143	Methods for treating a neurological disorder by peripheral administration of a trophic factor The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor c...	03/20/2012
8124392	Crystal structure of Aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto...	02/28/2012
8119631	Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace...	02/21/2012
8071295	DNA-based methods of geochemical prospecting The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analyses of a population. The invention further relates to methods for the creation of databases co...	12/06/2011
8067388	Decoy-containing pharmaceutical compositions and method of using the same A pharmaceutical composition is provided for treatment and prevention of a disease caused by expression of a gene controlled by NF-κB or ets. The composition comprises at least one decoy and a pharmaceutically acceptable carrier. The decoy is an NF-κB decoy, an et...	11/29/2011
8067224	Presenilin associated membrane protein (PAMP) and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,...	11/29/2011
RE42954	Method for repairing a defect in an intervertebral disc Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra...	11/22/2011
8017619	Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositi...	09/13/2011
8002891	Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets. ...	08/23/2011
7989498	Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e...	08/02/2011
7972813	Tetrodotoxin-resistant sodium channel alpha subunit The present invention is directed to a chimp sodium channel alpha subunit and methods and compositions for making and using the same. ...	07/05/2011
7960398	Regulation of TNF-alpha The present invention relates to methods for identifying compounds useful for regulating TNF-alpha levels and/or activity. The invention also relates to methods for decreasing TNF-alpha levels and/or activity. Compounds and compositions according to this invention a...	06/14/2011
RE42461	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4-substituted aryl;	06/14/2011
7919523	Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T...	04/05/2011
7919079	Cancer immunotherapy compositions and methods of use Cellular compositions and methods for inducing an immune response to tumor cells are described. The cellular compositions include a tumor antigen and cells that have been modified to express a cytokine and one or more of a tumor antigen, anti-CTLA4 antibody and an a...	04/05/2011
7888065	Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid ...	02/15/2011
7883881	Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ...	02/08/2011
7846679	Methods for detecting the presence of mutant mammalian presenilin protein The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri...	12/07/2010
7879606	Compositions and methods useful for HCV infection The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present i...	02/01/2011
7858083	Pan cancer oncolytic vectors and methods of use thereof Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replica...	12/28/2010
7838247	Antibody specific for mutant presenilin 2 and method of use thereof The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri...	11/23/2010
7823591	Female barrier contraceptive with vacuum anchoring A female condom has a pouch with an open end, a closed end, and a tubular body extending longitudinally therebetween. The female condom also includes an anchor attached to and outside of the closed end of the pouch. ...	11/02/2010
7809541	Crystal structure of aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto...	10/05/2010
7807659	Caspase inhibitors and uses thereof The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this inventio...	10/05/2010
7803369	Devices and method for repair of larynx, trachea, and other fibrocartilaginous tissues Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra...	09/28/2010
7795202	Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor c...	09/14/2010
7790713	Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace...	09/07/2010
7790669	Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α) The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) wi...	09/07/2010
7772366	Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace...	08/10/2010
7767879	Transgenic animal model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and...	08/03/2010
7745444	Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents....	06/29/2010
7714119	AAV vector compositions and methods for enhanced expression of immunoglobulins using the same Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequen...	05/11/2010
7709224	Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective prot...	05/04/2010
7700609	Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositi...	04/20/2010
7666647	Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ...	02/23/2010
7666646	Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design The present invention relates to the X-ray analysis of crystalline molecules or molecular complexes of human Pim-1. The present invention also relates to Pim-1-like binding pockets. The present invention provides a computer comprising a data storage medium encoded w...	02/23/2010
7662826	Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or ...	02/16/2010
7662623	Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective prot...	02/16/2010

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Attorney: Haley, Jr.; James F.