Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 6078948 | Platform-independent collaboration backbone and framework for forming virtual communities having virtual rooms with collaborative sessions Platform-independent collaboration backbone and framework for forming virtual communities having virtual rooms with collaborative sessions. Demon logic is embedded in a room page as downloadable platform-independent instructions. The demon, when downloade... | 06/20/2000 |
| 5827641 | In vitro cornea equivalent model This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an i... | 10/27/1998 |
| 5723754 | Tapetum-specific promoters from Brassicaceae spp Tapetum-specific promoters, designated A3 and A9 and capable of driving expression of 12.9 kDa and 11.6 kDa proteins in Arabidopsis thaliana and related proteins within the family Brassicaceae, have been discovered, isolated and cloned. The promoters can ... | 03/03/1998 |
| 5681581 | Controlled release pharmaceutical formulations of 3'-azido-3'-deoxythymidine and methods of use This invention is directed to controlled release pharmaceutical formulations of 3'-azido-3'-deoxythymidine, also known as AZT or zidovudine and methods of use thereof. The controlled release formulations of AZT achieve and maintain a therapeutic level of ... | 10/28/1997 |
| 5672686 | Bcl-Y - specific antibodies The present invention is directed to an isolated Bcl-Y protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences codi... | 09/30/1997 |
| 5670634 | Reversal of ଲ/A4 amyloid peptide induced morphological changes in neuronal cells by antisense oligonucleotides The invention provides oligonucleotides that inhibit the expression of ଲ/A4 peptide of Alzheimer's disease and Down's syndrome, and further provides methods for reversing morphological changes caused in neuronal cells by ଲ/A4 peptide.... | 09/23/1997 |
| 5663565 | System and method for the on-line measurement of key glue-line characteristics on corrugated board The system and method of the present invention determines glue-line characteristics, such as temperature, of corrugated board. Components of an on-line glue sensor's output signal that are oscillating at the fluting frequency are isolated. The components ... | 09/02/1997 |
| 5656725 | Peptides and compositions which modulate apoptosis The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed ... | 08/12/1997 |
| 5654961 | Routing system and method for a teleconferencing system In a networked videoconferencing system, a receiver with a number of receiving stations receives calls from a number of different calling stations. To get appropriate bandwidth, two calls are connected at the same time from the calling station to one of t... | 08/05/1997 |
| 5649095 | Method and apparatus for detecting computer viruses through the use of a scan information cache A method and apparatus is provided for scanning files for computer viruses which use the length of at least one portion (such as a fork) of a file. This length information is stored in a cache. During a scan, the then current size of the file portion is c... | 07/15/1997 |
| 5645833 | Inhibitor resistant serine proteases Serine proteases of the chymotrypsin superfamily are modified so that they exhibit resistance to serine protease inhibitors. If such modified serine proteases have fibrinolytic, thrombolytic, antithrombotic or prothrombotic properties, they are useful in ... | 07/08/1997 |
| 5643717 | Substrate useful for separating modified oligonucleotides Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12% polymer in at least 50% (volume:volume) organic solvent, the organic solvent being a denaturing agent. This su... | 07/01/1997 |
| 5643964 | Natural amino acid derivatives as metalloproteinase inhibitors Compounds of Formula (I) wherein R2 represents a group R6 --A-- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R | 07/01/1997 |
| 5641459 | Machine for synthesizing oligonucleotides A machine for synthesizing oligonucleotides has individual pumping modules for connection to each of a number of different monomers and to other fluids used in the synthesizing process. Each pumping module includes a pump and a three-port/three-way valve ... | 06/24/1997 |
| 5637464 | Method of detecting sub-ppb levels of oligonucleotides in biological fluids Disclosed is a method of detecting a single-stranded target oligonucleotide in a biological fluid. In this method, a biological fluid sample to-be-tested is contacted with helper and primer oligonucleotides, thereby forming a labelled, double-stranded mol... | 06/10/1997 |
| 5635640 | Micromachined device with rotationally vibrated masses A micromachined device has a plurality of rotationally dithered masses that are used to sense acceleration. To eliminate common modes, the masses are dithered in an equal and opposite manner. To help maintain this relationship between the movement of the ... | 06/03/1997 |
| 5634647 | Braking device particularly for skates Braking device, particularly usable for skates which include a shoe composed of a quarter which is articulated to a shell which is in turn associated with a supporting frame for two or more wheels. The device includes at least one elastic strut that allow... | 06/03/1997 |
| 5632637 | Cable connector A self-terminating connector has a movable conductor for automatically terminating a connector that carries an RF signal when the connector is disconnected from a corresponding connector. The connector terminates through a 75 ohm resistance that is mounte... | 05/27/1997 |
| 5630791 | Orthotic joint Disclosed is an orthotic joint for an orthotic knee, hip or other similar brace that would eliminate the use of sidebars and would automatically lock upon full extension. The locking mechanism could also be fixed in an unlocked position if desired. Instea... | 05/20/1997 |
| 5631598 | Frequency compensation for a low drop-out regulator A low drop-out voltage regulator is compensated by providing a compensation capacitor across an output terminal of the regulator and an output lead of an input stage which compares a reference voltage and a voltage derived from a regulated output signal a... | 05/20/1997 |
| 5630990 | Ozone generator with releasable connector and grounded current collector A generator is taught which uses alternating current or pulsating direct current to produce ozone from oxygen. The generator comprises a high voltage and ground electrode separated to form a gap for accommodating a dielectric member and gas to be reacted.... | 05/20/1997 |
| 5627764 | Automatic electronic messaging system with feedback and work flow administration A rule based electronic messaging system with a facility for automatically running a user's rules under system control without need for user intervention or attendance, having a feedback mechanism which reports status relating to users automatically proce... | 05/06/1997 |
| 5627055 | Finderons and methods of their preparation and use Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at l... | 05/06/1997 |
| 5627277 | Method for analyzing oligonucleotide analogs Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12% (weight:volume) polymer in at least 5M urea and at least 32% (volume:volume) organic solvent, the organic solv... | 05/06/1997 |
| 5625567 | Electronic circuit design system and method with programmable addition and manipulation of logic elements surrounding terminals A system and method for programmatically adding pads and ports and altering design logic at the terminals of electronic circuit designs is provided. In a preferred embodiment the system and method are implemented within a system that partitions arbitrary ... | 04/29/1997 |
| 5621157 | Method and circuitry for calibrating a micromachined sensor To calibrate an accelerometer having a ground plane, two fixed beams, and a movable beam centered between the fixed beams, a force/acceleration reference is produced by providing a change in voltage on the ground plane. Circuit gain is adjusted so that th... | 04/15/1997 |
| 5616565 | Cyclodextrin cellular delivery system for oligonucleotides Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is nonco... | 04/01/1997 |
| 5614622 | 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more mild conditions than existing methods. The invention further provides a nucleoside base protective group that is stable unde... | 03/25/1997 |
| 5614835 | Method and apparatus for handling a packaged integrated circuit device for testing A carrier is used to couple a packaged device having leads of a certain length to a testing device. The carrier includes an adapter for receiving packaged dies with leads that are cut so that they are otherwise too short for the testing device. The adapte... | 03/25/1997 |
| 5608728 | System and method for equalization of forward and reverse channels of a communication network system A system and method for equalization for forward and reverse channels of communicating highway network system having a branching tree topology. The system and method cause the forward channel to be adjusted first for equalization, then the reverse channel... | 03/04/1997 |
| 5606979 | Guide wire A method and apparatus for producing a guide wire including a core wire surrounded by a heat shrunk polymeric plastic sleeve of variable wall thickness. The core wire is inserted into the sleeve, and heat is applied to successive axially spaced annular zo... | 03/04/1997 |
| 5605890 | Cyclodextrin cellular delivery system for oligonucleotides Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is nonco... | 02/25/1997 |
| 5585772 | Magnetostrictive superconducting actuator An actuator in which a magnetostrictor is subjected to magnetic fields produced by a superconducting coil, and the magnetostrictor and coil are maintained at temperatures below the magnetic transition temperature of the magnetostrictor and the superconduc... | 12/17/1996 |
| 5581353 | Laser-based measurement apparatus and method for the on-line measurement of multiple corrugated board characteristics The apparatus and method of the present invention utilize a pair of fixed-position laser triangulation sensors, with one sensor located above the board and one directly below. Each sensor produces a measurement signal proportional to the distance between ... | 12/03/1996 |
| 5579519 | Extensible electronic document processing system for creating new classes of active documents An improved document processing system for creating computer procedures (i.e., methods) and associating them with an electronic document structured as a nested hierarchy of constituent objects. The system includes a document processing means for creating ... | 11/26/1996 |
| 5578716 | DNA methyltransferase antisense oligonucleotides The invention encompasses tumorigenicity-inhibiting antisense oligonucleotide sequences complementary to mRNA or double-stranded DNA that encodes mammalian DNA methyl transferase. It further encompasses methods for inhibiting tumorigenicity and pharmaceut... | 11/26/1996 |
| 5578224 | Method of making micromachined device with ground plane under sensor A polysilicon ground plane is formed over dielectric layers and under a suspended, movable mass in a surface micromachined device. The process includes steps of forming a diffused region in a substrate, forming the dielectric layers over the substrate, fo... | 11/26/1996 |
| 5570759 | Braking device particularly for skates Braking device, particularly for skates including a shoe associated with a frame having wheels. The device includes a rod member associated with the shoe and with a support for a brake that interacts with the ground. The rod member is hinged to the shoe a... | 11/05/1996 |
| 5570699 | Controlled surgical core biopsy system A controlled surgical core biopsy system that is operated with one hand. The system includes a gun unit, a needle adaptor system, and the needle assembly. The needle adaptor system links the needle assembly to the gun unit. The gun unit may have a single ... | 11/05/1996 |
| 5567445 | Gauge band randomizer An oscillating hauloff device for removing blown film from an extruding apparatus. The oscillating hauloff includes a stacked ring arrangement which provides a compact and stable structure. The turning bars and idler rolls are encompassed in the ring stru... | 10/22/1996 |
