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| Number | Title | Issue Date |
| 6677501 | P2X7 receptor-deficient mice and uses thereof The invention provides non-human, genetically-modified mammals and genetically modified animals cells having a functionally disrupted P2×7 receptor gene. Also provided are methods for producing genetically modified mice in which one or both P | 01/13/2004 |
| 6622258 | Data protection in a ring network A method for reconfiguring a ring of nodes connected by a working fiber and a protection fiber upon disruption of the signal in either the working fiber or the protection fiber includes signaling the other nodes. Each node determines whether it is a node ... | 09/16/2003 |
| 6604033 | Wireless diagnostic system for characterizing a vehicle's exhaust emissions The invention features a method and apparatus for remotely characterizing a vehicle's emissions performance. The method features the steps of: i) generating data representative of the vehicle's emissions performance with at least one microcontroller dispo... | 08/05/2003 |
| 6599514 | Antifungal composition Antifungal compositions having enhanced antifungal activity comprising an antifungal agent and a food additive are described. Also described are a method for inhibiting fungal growth using the compositions with enhanced activity and the use of a food addi... | 07/29/2003 |
| 6580955 | Apparatus, method and medium for enhancing the throughput of a wafer processing facility using a multi-slot cool down chamber and a priority transfer scheme An apparatus, method and medium is provided for increasing the efficiency with which wafers are transferred among different processing chambers in a wafer processing facility. A multi-slot cooling chamber allows multiple wafers to be cooled while other wa... | 06/17/2003 |
| 6542585 | Distributed splitter for data transmission over twisted wire pairs A system that provides video signal communication between a source of the video signal and a plurality of units that include destinations of the video signal includes an interface coupled to the source and to telephone lines, each of which serves at least... | 04/01/2003 |
| 6517585 | Lower limb prosthesis A lower limb prosthesis for an above-knee amputee has an adaptive control system which includes a knee flexion control device arranged to resist flexion at the knee joint both hydraulically and pneumatically by means of a dual piston and cylinder assembly... | 02/11/2003 |
| 6513969 | Pressure perturbation calorimetry instruments and methods A calorimeter that includes a sample cell, a reference cell, a pressure system that applies a variable pressure to the sample cell, and a pressure controller that controls the pressure applied by the pressure system to the sample sell. By applying identic... | 02/04/2003 |
| 6471978 | Localized use of nitric oxide-adducts to prevent internal tissue damage A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide ... | 10/29/2002 |
| 6447723 | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments The disclosed spotting instrument includes one or more sensors that are mechanically fixed to the instrument's printhead. The sensors enable the instrument to detect whether a substrate is mounted in a particular holder of the instrument's substrate stati... | 09/10/2002 |
| 6440660 | Oligonucleotide mediated reversal of drug resistance The present invention provides methods of resensitizing an anti-drug-resistant infectious agent to a drug. Also disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to a region of pfmdr1 nucleic acid, and methods of down-reg... | 08/27/2002 |
| 6436876 | Processing of oxide superconductors A method for preparing a BSCCO-2223 oxide superconducting article includes annealing an oxide superconductor article comprised of BSCCO-2223 oxide superconductor at a temperature selected from the range of about 500° C.ࣘTࣘ787° C. and an annealing at... | 08/20/2002 |
| 6391883 | Bicyclic amines A compound of formula (I): ##STR1## wherein R1 represents a group of formula (A) where each of W, X, Y and Z and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom a... | 05/21/2002 |
| 6341250 | Low energy method for changing the inclinations of orbiting satellites using weak stability boundaries and a computer process for implementing same When a satellite is orbiting the earth in an elliptic orbit, it has a certain inclination with respect to the earth's equator. The usual way to change the inclination is perform a maneuver by firing the rocket engines at the periapsis of the ellipse. This... | 01/22/2002 |
| 6316457 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The ... | 11/13/2001 |
| 6306651 | Specific tolerance in transplantation In general, the invention features, a method of inducing tolerance in a recipient mammal, e.g., a human, of a first species to a tissue obtained from a mammal, e.g., a swine, e.g., a miniature swine, of a second species, which tissue expresses an MHC anti... | 10/23/2001 |
| 6294517 | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, or stimulate nitric... | 09/25/2001 |
| 6291424 | Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 09/18/2001 |
| 6262600 | Isolator for transmitting logic signals across an isolation barrier A logic isolation circuit has a transmitter circuit for receiving a logic input signal and providing a periodic signal to an isolation barrier, and a receiving circuit for receiving the periodic signal from the isolation barrier and for providing an outpu... | 07/17/2001 |
| 6177985 | Apparatus and method for testing optical fiber system components An optical switching assembly selectively connects an optical source and a detector to at least one fiber optic device. The assembly includes first and second groups of optical paths, and first and second optical switches. The first optical switch selecti... | 01/23/2001 |
| 6054127 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 04/25/2000 |
| 5955331 | Recombinant retroviruses with amphotropic and ecotropic host ranges Packaging cell lines useful for the generation of helper-free recombinant retroviruses with amphotropic or ecotropic host ranges, methods of constructing such packaging cell lines and methods of using the recombinant retroviruses to introduce DNA of inter... | 09/21/1999 |
| 5919693 | Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum The present invention describes the isolation and sequence of genes from Flavobacterium heparinum encoding heparin and heparan sulfate degrading enzymes, heparinase II and heparinase III (EC 4.2.2.8). It further describes a method of expressing and an exp... | 07/06/1999 |
| 5892320 | Field emission display with self-aligned grid A field emission display includes a substrate (400) having a trench (402) formed therein, an emitter (418) formed in the trench (402), a dielectric layer (412) disposed on the substrate (400), and a grid material layer (406) disposed on the dielectric lay... | 04/06/1999 |
| 5876783 | Radiopaque medical devices A method and apparatus for producing a guide wire including a core wire a distal portion of which is surrounded by a helically wound spring. The coils forming the distal portion of the spring include a annular layer of radiopaque material, e.g., gold, ion... | 03/02/1999 |
