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| Number | Title | Issue Date |
| 8173815 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 05/08/2012 |
| 8163920 | Quinolinone-carboxamide compounds as 5-HTreceptor agonists The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 re... | 04/24/2012 |
| 8163794 | Crystalline form of a 3-phenoxymethylpyrrolidine compound The invention provides a crystalline hydrochloride salt of (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline ... | 04/24/2012 |
| 8158659 | Dual-acting imidazole antihypertensive agents The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT | 04/17/2012 |
| 8158580 | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical com... | 04/17/2012 |
| 8153686 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists The invention provides amino- and amido-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, and n are defined in the speci... | 04/10/2012 |
| 8153675 | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S) -2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2 -carboxylic acid. This invention also provides pharmaceutical compositions comprising the crysta... | 04/10/2012 |
| 8143298 | Dual-acting antihypertensive agents The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have A... | 03/27/2012 |
| 8143279 | Benzimidazole-carboxamide compounds as 5-HTreceptor agonists The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate... | 03/27/2012 |
| 8143277 | Method of using compounds having βadrenergic receptor agonist and muscarinic receptor antagonist activity This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, W, a,... | 03/27/2012 |
| 8138345 | Diamide compounds having muscarinic receptor antagonist and βadrenergic receptor agonist activity This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities. The inven... | 03/20/2012 |
| 8134006 | Dialkylphenyl compounds having βadrenergic receptor agonist and muscarinic receptor antagonist activity This invention relates to compounds of formula I: wherein R1 and R2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereo... | 03/13/2012 |
| 8133905 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compou... | 03/13/2012 |
| 8124627 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, R1, R2, and R3 are as defined in the specification. The compounds... | 02/28/2012 |
| 8119796 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula ... | 02/21/2012 |
| 8119634 | Dual-acting pyrazole antihypertensive agents In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These ... | 02/21/2012 |
| 8106232 | 3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a phar... | 01/31/2012 |
| 8106082 | Dual-acting antihypertensive agents The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT | 01/31/2012 |
| 8101794 | Crystalline forms of a 3-carboxypropyl-aminotetralin compound The invention provides crystalline solid forms of (S)-4-((2S,3S)-7-carbamoyl-1,1 -diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid. The invention also provides pharmaceutical compositions comprising such crystalline solid for... | 01/24/2012 |
| 8101791 | Aminotetralin compounds as mu opioid receptor antagonists The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a... | 01/24/2012 |
| 8101766 | Crystalline form of a biphenyl compound The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof... | 01/24/2012 |
| 8101575 | Glycopeptide phosphonate derivatives Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial ... | 01/24/2012 |
| 8093354 | Process for preparing glycopeptide phosphonate derivatives Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less wast... | 01/10/2012 |
| 8084417 | Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacteria... | 12/27/2011 |
| 8080572 | Dual-acting antihypertensive agents In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compou... | 12/20/2011 |
| 8080565 | Substituted 4-amino-benzylpiperidine compounds This invention provides 4-amino-1-benzylpiperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes ... | 12/20/2011 |
| 8067439 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specificat... | 11/29/2011 |
| 8053448 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides methods of using compounds of formula Ib below to treat pulmonary disorders. wherein: R4 is hydrogen or (1-4C)alkyl; q is 0, 1, or 2; | 11/08/2011 |
| 8044195 | Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacter... | 10/25/2011 |
| 8044045 | Indazole-carboxamide compounds as 5-HTreceptor agonists The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 10/25/2011 |
| 8034946 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 10/11/2011 |
| 8030502 | Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; p... | 10/04/2011 |
| 8030445 | Glycopeptide derivative Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical composit... | 10/04/2011 |
| 8017783 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 09/13/2011 |
| 8017617 | Amidine-containing compounds useful as muscarinic receptor antagonists The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. ... | 09/13/2011 |
| 8013152 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula ... | 09/06/2011 |
| 8013005 | Dual-acting antihypertensive agents The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1... | 09/06/2011 |
| 8008278 | Diarylmethyl and related compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a,... | 08/30/2011 |
| 8003755 | Hydrochloride salts of a glycopeptide phosphonate derivative Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are pro... | 08/23/2011 |
| 8003664 | Indazole-carboxamide compounds The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 08/23/2011 |
