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| Number | Title | Issue Date |
| 8168399 | Supports for assaying analytes and methods of making and using thereof Described herein are supports for assaying an analyte and methods of making and using thereof. ... | 05/01/2012 |
| 8163561 | Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The senso... | 04/24/2012 |
| 8158340 | Methods for detecting conformational changes in bioentities Described herein are methods for detecting conformational changes in bioentities. ... | 04/17/2012 |
| 8148092 | System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor... | 04/03/2012 |
| 8133422 | Alkylcellulose salt binder for green body manufacture A batch mixture including ceramic-forming ingredients, a pore former, a binder comprising an ammonium salt of an alkylated cellulose binder, and a liquid vehicle, as defined herein. Also disclosed is a method for producing a ceramic precursor article as defined here... | 03/13/2012 |
| 8129198 | Porous substrate plates and the use thereof A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The... | 03/06/2012 |
| 8105822 | Biosensor article and methods thereof A biosensor or cell culture article including: a substrate having a bio-compatible layer. The bio-compatible layer can be obtained from surface oxidation of a substrate coating comprising the reaction product of a suitable oxidizable polymer and modifier compound, s... | 01/31/2012 |
| 8101405 | Nanoparticulate affinity capture for label independent detection system A biosensor article including a substrate having nanoparticles on the substrate surface, the nanoparticle including: a polymer of formula (I) where (x), (y)... | 01/24/2012 |
| 8088877 | Photo or electron beam curable compositions A curable composition and a process for using the curable composition within a grating-coupled waveguide (GCW) sensor are disclosed. The composition can be used for facile replication of optical components, specifically those used in a label-independent detection sy... | 01/03/2012 |
| 8076090 | Label free biosensors and cells Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed. ... | 12/13/2011 |
| 8062900 | Optically readable microplate A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of pred... | 11/22/2011 |
| 8058347 | Composites and methods of making and using the composites A composite including interpenetrating networks of an organic polymer, such as from an acrylate or olefin, having urethane groups; and an inorganic polymer, the composite having a low or no-shrinkage characteristic, and a method for making the composite, as defined ... | 11/15/2011 |
| 8049883 | Wavelength tracker for swept wavelength sensor interrogation system A swept wavelength interrogation system includes a tunable light source for outputting a light beam that is tunable over a range of wavelengths and an optical reader head for distributing the light beam among a plurality of sensors and for measuring response spectra... | 11/01/2011 |
| 7998414 | System for high throughput GPCR functional assay A functional assay detection system for membrane bound proteins. The system comprises a biological array including a porous substrate having a plurality of membranes adhered thereto and a first side and a second side, a fluorescent labeling reagent configured to cou... | 08/16/2011 |
| 7981665 | Supports for assaying analytes and methods of making and using thereof Described herein are supports for assaying an analyte and methods of making and using thereof. ... | 07/19/2011 |
| 7978893 | System and method for microplate image analysis A system and a method as defined herein for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis. ... | 07/12/2011 |
| 7964262 | Layered silicate modified cordierite and method The disclosure provides a composition including a porous cordierite honeycomb body as defined herein having excellent strength, high thermal shock resistance, and reduced microcrack properties. The disclosure also provides methods of making and using the composition... | 06/21/2011 |
| 7939687 | Sol-gel-polymer nanocomposite and methods thereof A nanocomposite material including organic-inorganic polymeric interpenetrating networks having a low or no-shrinkage characteristic and a method for making the composite, as defined herein. ... | 05/10/2011 |
| 7937971 | Methods for drawing optical fibers using a fluid bearing Methods for producing optical fibers along nonlinear paths include incorporating fluid bearings. An optical fiber is drawn from a preform along a first pathway, contacted with a region of fluid cushion of a fluid bearing, and redirected along a second pathway as the... | 05/10/2011 |
| 7923241 | Cell culture article and methods thereof Disclosed is a cell culture article including: a substrate; a tie-layer attached to at least the substrate; and a bio-compatible layer attached to at least the tie layer, the bio-compatible layer having been obtained from surface oxidation of a polymer layer. Also d... | 04/12/2011 |
| 7919634 | Fused thiophenes, articles, and methods thereof Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein. ... | 04/05/2011 |
| 7919328 | Fluorescent ion doped glass and method for using the fluorescent ion doped glass to enhance fluorescence imaging techniques A fluorescent ion doped glass (or other fluorescing material) and a method for using the fluorescent ion doped glass to enhance a fluorescence imaging technique are described herein. In one embodiment, the fluorescent ion doped glass (or other fluorescing material) ... | 04/05/2011 |
| 7916763 | Current driven frequency-stepped radiation source and methods thereof A wavelength tunable system including: a laser having a lasing cavity and an external cavity; a frequency-adjuster in the external cavity; and an adjustable current source to adjust the laser diode current, and a method of use as defined herein. ... | 03/29/2011 |
| 7914874 | Fugitive pore former for porous ceramic articles Disclosed are ceramic batch compositions for forming porous ceramic articles. The ceramic forming precursor batch compositions include ceramic forming inorganic batch components and a cyclododecane pore forming agent. Also disclosed are methods for manufacturing por... | 03/29/2011 |
| 7867936 | Process for passivating porous ceramic articles and an article made therefrom A method for passivating a porous ceramic article containing microcracks including filling the microcracks with a liquid, such as water, and then applying a washcoat as described herein. ... | 01/11/2011 |
| 7867700 | Porous substrate plates and the use thereof A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The... | 01/11/2011 |
| 7842516 | Detectable labels, methods of manufacture and use Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interaction... | 11/30/2010 |
| 7824624 | Closed flow-through microplate and methods for using and manufacturing same A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . that is helpful for example with testing new drugs. A method... | 11/02/2010 |
| 7819320 | System and method for image analysis pointing-error correction The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be ... | 10/26/2010 |
| 7816096 | Assay solution compositions and methods for GPCR arrays Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about... | 10/19/2010 |
| 7799885 | Photo or electron beam curable compositions A curable composition and a process for using the curable composition within a grating-coupled waveguide (GCW) sensor are disclosed. The composition can be used for facile replication of optical components, specifically those used in a label-independent detection sy... | 09/21/2010 |
| 7781203 | Supports for assaying analytes and methods of making and using thereof A support for performing an assay, including: a substrate having a pre-blocked binding polymer directly or indirectly attached to the substrate, the pre-blocked binding polymer having a plurality of maleic anhydride reactive groups capable of attaching to a biomolec... | 08/24/2010 |
| 7704296 | Fine porosity low-microcracked ceramic honeycombs and methods thereof Disclosed are high-porosity cordierite honeycomb substrates having fine pore size, narrow pore size distribution, little or no microcracking, and a high thermal shock resistance. The porous ceramic honeycomb substrates generally include a primary cordierite ceramic ... | 04/27/2010 |
| 7691580 | Reverse protein delivery into cells on coded microparticles Systems, methods and kits that utilize uniquely coded microparticles for performing protein assays are provided. The uniquely coded microparticles are used as a substrate for reverse protein delivery into cells. The microparticles and methods offer the possibility o... | 04/06/2010 |
| 7682802 | Assay solution compositions and methods for GPCR arrays Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about... | 03/23/2010 |
| 7678539 | Arrays of biological membranes and methods and use thereof The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an a... | 03/16/2010 |
| 7671227 | Asymmetric bis-silanes and methods for making and their use An asymmetric bis-silane compound of the formula A3Si—R1—SiB3 where A, B, and R1 are as defined herein, and to methods for making the bis-silane compound and their use to form layers or films of me... | 03/02/2010 |
| 7609923 | Preterminated fiber optic cable including downstream splitter An optical splitter adjacent a downstream end of a fiber optic cable is operable for supplying an optical signal to at least one optical fiber from the downstream end of the fiber. A preterminated fiber optic distribution cable includes a first access location havin... | 10/27/2009 |
| 7582486 | Double resonance interrogation of grating-coupled waveguides A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical ag... | 09/01/2009 |
| 7473533 | Membrane arrays and methods of manufacture The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR micr... | 01/06/2009 |
