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| Number | Title | Issue Date |
| 8114428 | Methods for manufacturing a composition for treating bone and/or cartilage defects The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone a... | 02/14/2012 |
| 8093217 | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oli... | 01/10/2012 |
| 8076639 | Method and system for desorption atmospheric pressure chemical ionization A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. ... | 12/13/2011 |
| 8017125 | Copolymers for suppression of autoimmune diseases, and methods of use Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymer... | 09/13/2011 |
| 7931687 | Tissue engineered osteochondral implant Compositions, methods of production and use, and kits for an osteochondral graft involving both articular cartilage and underlying bone are provided. ... | 04/26/2011 |
| 7910377 | Methods and apparatuses for preparing a surface to have catalytic activity The invention provides methods and apparatuses that utilize mass spectrometry for preparation of a surface to have catalytic activity through molecular soft-landing of mass selected ions. Mass spectrometry is used to generate combinations of atoms in a particular ge... | 03/22/2011 |
| 7847244 | Enclosed desorption electrospray ionization An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sam... | 12/07/2010 |
| 7840987 | Television messaging vocal response generation In a messaging system adapted to operate in a television environment, the invention teaches a method and apparatus for allowing a user to enter textual outgoing message, which is translated to speech by text to speech module. The speech is than delivered to a target... | 11/23/2010 |
| 7747454 | System and method for real time management of a drug regimen A system for managing a prescribed drug regimen for a user, the system including at least one electronic device (Pod) for interactive communication with at least one user, a Pod server coupled via a communication link to each Pod, said Pod server including an analys... | 06/29/2010 |
| 7647617 | Method for association between telephony and television network equipment A method for user assisted association between a television and a telephony device is provided. A set-top box requests an identification code from a server. The server identifies the set-top box, generates the code and transmits it to the set-top box. The set-top bo... | 01/12/2010 |
| 7571458 | Method and apparatus for selecting and displaying multi-media messages Apparatus and method for remote viewing of selected messages at a subscriber remote receiving location, the apparatus including at least one messaging server (such as, but not limited to, a unified messaging system, voice-mail system, fax server system, or any other... | 08/04/2009 |
| 7566767 | Synthetic peptides and methods of use for autoimmune disease therapies The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also provides kits for assaying binding of a composition to a water-soluble M... | 07/28/2009 |
| 7556929 | Compositions and methods for screening anti-cancer agents in yeast Methods and kits for identifying novel anti-tumor agents are provided. ... | 07/07/2009 |
| 7544933 | Method and system for desorption atmospheric pressure chemical ionization A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. ... | 06/09/2009 |
| 7456252 | Therapeutic peptides for demyelinating conditions The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition. ... | 11/25/2008 |
| 7448157 | Harpoon device and methods of use A harpoon device is provided which has attachable components, including a plurality of lengths of shaft segments joined by a coupler and a variety of functional units. ... | 11/11/2008 |
| 7412795 | Collapsible dredge and methods of use therefor A unitary, rotational, and collapsible luring dredge capable is rapid and convenient assembly for use and collapse for storage is provided, as are methods and kits for use. ... | 08/19/2008 |
| 7381790 | Copolymers for suppression of autoimmune diseases, and methods of use Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymer... | 06/03/2008 |
| 7381557 | Compositions and methods for bacterial immunity and secretion of proteins Attenuated strains of Gram negative bacteria carrying a mutation in one or more ysc genes or homologs are provided, as are methods of use for immunization against infection with a pathogenic strain and for delivery of a therapeutic agent. ... | 06/03/2008 |
| 7381373 | System and method for preparative mass spectrometry A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion tra... | 06/03/2008 |
| 7361311 | System and method for the preparation of arrays of biological or other molecules A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions acc... | 04/22/2008 |
| 7346919 | Television messaging vocal response generation In a messaging system adapted to operate in a television environment, the invention teaches a method and apparatus for allowing a user to enter textual outgoing message, which is translated to speech by text to speech module. The speech is than delivered to a target... | 03/18/2008 |
| 7335897 | Method and system for desorption electrospray ionization A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing ... | 02/26/2008 |
| 7328549 | Process for aseptic vacuum filling and stoppering of low viscosity liquids in syringes A process by which low viscosities liquids are filled into syringes without gas bubbles utilizing lowered temperature and valves to isolate the filling system from the vacuum. The liquid may be drug, device, pharmaceutical, and/or biotech products. ... | 02/12/2008 |
| 7249952 | Methods and apparatus for simulating dental procedures and for training dental students A training system using haptically enhanced simulations of dental procedures to provide the sensorimotor involvement needed for dental training. To provide touch feedback in combination with a realistic visual experience, the system integrates a haptic stylus interf... | 07/31/2007 |
| 7247437 | Vibrionaceae replication factors and methods of use thereof The invention relates to compositions, methods and kits useful in modulating bacterial cell DNA replication and for treating pathogenic bacterial. ... | 07/24/2007 |
| 7189697 | Compositions and uses of a galectin for treatment of dry eye syndrome Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provide... | 03/13/2007 |
| 7177018 | Multiplex illuminator and device reader for microcantilever array A device reader having a multiplex illuminator, the illuminator, and methods for reading deflection of a large number of microcantilevers are provided. The illuminator includes a micro-optical subassembly for illuminating cantilevers (illuminator) that uses a plural... | 02/13/2007 |
| 7141385 | Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectiv... | 11/28/2006 |
| 7074929 | Certain alkylene diamine-substituted heterocycles This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula II, IV, V, VII–IX and X... | 07/11/2006 |
| 7048907 | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotop... | 05/23/2006 |
| 7034034 | Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety... | 04/25/2006 |
| 6994992 | Androgen-induced suppressor of cell proliferation and uses thereof The invention provides novel AS3 nucleic acid sequences, AS3 polypeptides, anti-AS3 antibodies, and methods for modulating cell proliferation and detecting compounds that modulate cell proliferation. Diagnostic and therapeutic methods utilizing compositions of the i... | 02/07/2006 |
| 6979728 | Articles of manufacture and methods for array based analysis of biological molecules The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemical... | 12/27/2005 |
| 6967021 | Use of Galectin-3 to promote the re-epithelialization of wounds Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3 protein and/or a galectin-7 protein are provided. Pharmaceutical composit... | 11/22/2005 |
| 6943199 | Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are part... | 09/13/2005 |
| 6858713 | Chemically modified biological molecules and methods for coupling biological molecules to solid support The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the gla... | 02/22/2005 |
| 6808886 | Methods for array-based comparitive binding assays The invention provides computer systems, computer program products and methods for in silico array-based methods for determining the relative amount of biological molecules (e.g., nucleic acid sequences) in two or more samples. The invention also provides novel arra... | 10/26/2004 |
| 6762056 | Rapid method for determining potential binding sites of a protein A method for discovering proteins and protein geometries, and a method for conducting whole proteome assays on a single test surface are disclosed. A test surface is provided featuring a surface containing a random distribution of randomly shaped features of a size ... | 07/13/2004 |
