"Flight by machines heavier than air is unpractical and insignificant, if not utterly impossible."
Simon Newcomb, astronomer ; Said in 1902, less than two years before the first flight at Kitty Hawk
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| Number | Title | Issue Date |
| 6006745 | Device for delivering an aerosol A device for delivering an aerosol comprises a casing member, a valve stem, and a sealing member, wherein the sealing member comprises a thermoplastic elastomer comprising of a copolymer of about 80-95 mole % ethylene and about 5-20 mole % of at least one... | 12/28/1999 |
| 5776434 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 07/07/1998 |
| 5766573 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 06/16/1998 |
| 5736553 | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo4,5-C!quinolin-4-amine Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo4,5-c!-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological method... | 04/07/1998 |
| 5725841 | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.... | 03/10/1998 |
| 5702720 | Transdermal device for the delivery of flurbiprofen A transdermal drag delivery device involving an acrylate or methacrylate based copolymer, a skin penetration enhancer, a polyvinylpyrrolidone polymer, and a therapeutically effective amount of flurbiprofen.... | 12/30/1997 |
| 5698217 | Transdermal drug delivery device containing a desiccant A transdermal drug delivery device involving a carrier containing a dissolved drug. The device also involves a desiccant package that is inert to the carrier, permeable to water vapor, and defines a desiccant compartment containing a desiccant. The device... | 12/16/1997 |
| 5695743 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 12/09/1997 |
| 5693811 | Process for preparing tetrahdroimidazoquinolinamines A process for preparing 6, 7, 8, 9-tetrahydro-1H-imidazo4,5-c!quinolin-4-amines is disclosed. The process involves the reduction of a 1H-imidazo4,5-c!quinolin-4-amine or of a 6H-imidazo4,5-c!tetrazolo1,5-a!quinoline.... | 12/02/1997 |
| 5688520 | Transmucosal delivery of melatonin for prevention of migraine A method of reducing the frequency of and/or preventing migraine, involving the step of administering melatonin, preferably to and across a mucosal surface, in an amount and for a time sufficient to increase the period of time between episodes of migraine... | 11/18/1997 |
| 5688523 | Method of making a pressure sensitive skin adhesive sheet material A method of making a pressure sensitive skin adhesive sheet material whereby a coating medium involving a liquid and a polymer is applied to a base layer of a polymer, and the liquid is allowed to diffuse into the base layer.... | 11/18/1997 |
| 5681545 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 10/28/1997 |
| 5674473 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 10/07/1997 |
| 5669376 | Aerosol actuator having a linearly arranged canister receiving cavity, valve stem receptacle, orifice, and deagglomeration chamber An actuator for use in inhalation therapy comprising a nozzle .block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formula... | 09/23/1997 |
| 5655523 | Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation An inhalation device for dry powder containing a chamber capable of receiving a dose of powdered medicament. The chamber is in communication with a patient port in the form of a mouthpiece or nasal adapter. The inhalation device also contains a deagglomer... | 08/12/1997 |
| 5653961 | Butixocort aerosol formulations in hydrofluorocarbon propellant Pharmaceutical solution aerosol formulations of butixocort propionate as the sole active drug agent and a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and a mixture thereof.... | 08/05/1997 |
| 5648516 | Fused cycloalkylimidazopyridines 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon () biosynthesis in human cells, their pharmaceutical compositions containing such compounds and methods of inducing interferon () biosynthesis and... | 07/15/1997 |
| 5644063 | Imidazo[4,5-c]pyridin-4-amine intermediates Imidazo[4,5-c]pyridin-4-amines that induce interferon () biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon () biosynthesis involving the use of such compo... | 07/01/1997 |
| 5639469 | Transmucosal delivery system A device for delivering a heparinic anticoagulant across a mucosal surface in order to achieve or maintain a therapeutically effective blood level of the heparinic anticoagulant. The device involves a matrix containing a therapeutically effective amount o... | 06/17/1997 |
| 5627281 | Intermediate compounds of fused cycloalkylimidazopyridines 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines and their intermediate compounds are described. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon () biosynthesis and ... | 05/06/1997 |
| 5614210 | Transdermal device for the delivery of alfuzosin A transdermal drug delivery device involving an acrylate or methacrylate based adhesive copolymer, a skin penetration enhancer, and a therapeutically effective amount of alfuzosin.... | 03/25/1997 |
| 5612377 | Method of inhibiting leukotriene biosynthesis A method of inhibiting leukotriene biosynthesis, involving administering a compound of the formula: ##STR1## wherein M, R, R', R", and n are as defined herein. Also, a pharmaceutical composition involving such a compound and the use of such compounds... | 03/18/1997 |
| 5605674 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 02/25/1997 |
| 5605899 | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 02/25/1997 |
| 5602256 | Process for 1H-imidazo[4,5-C]quinolines A process for the preparation of 1-substituted,4-substituted-1H-imidazo-[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates.... | 02/11/1997 |
| 5585111 | Transdermal delivery device A transdermal drug delivery device involving a backing bearing at least one adhesive layer of an acrylate copolymer and a therapeutically effective amount of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole. The device optionally further involves (i) a s... | 12/17/1996 |
| 5578727 | Process for 1H-imidazo[4,5-c]quinolines A process for the preparation of 1-substituted,4-substituted-1H-imidazo-[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates.... | 11/26/1996 |
| 5569450 | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.... | 10/29/1996 |
| 5533498 | Aerosol actuator having a linearly arranged canister receiving cavity, valve stem receptacle, orifice, and deagglomeration chamber An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulat... | 07/09/1996 |
| 5527824 | Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.... | 06/18/1996 |
| 5525612 | 1-substituted 1H-imidazo-[4,5-c]quinolin-4-amines 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.... | 06/11/1996 |