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Attorney: Griswold; Gary L., Kirn; Walter N., Ringsred; Ted K.


Number of patents: 31
Last date: December 28, 1999

NumberTitleIssue Date
6006745Device for delivering an aerosol
A device for delivering an aerosol comprises a casing member, a valve stem, and a sealing member, wherein the sealing member comprises a thermoplastic elastomer comprising of a copolymer of about 80-95 mole % ethylene and about 5-20 mole % of at least one...
12/28/1999
5776434Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
07/07/1998
5766573Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
06/16/1998
5736553Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo›4,5-C!quinolin-4-amine
Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo›4,5-c!-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological method...
04/07/1998
5725841Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid....
03/10/1998
5702720Transdermal device for the delivery of flurbiprofen
A transdermal drag delivery device involving an acrylate or methacrylate based copolymer, a skin penetration enhancer, a polyvinylpyrrolidone polymer, and a therapeutically effective amount of flurbiprofen....
12/30/1997
5698217Transdermal drug delivery device containing a desiccant
A transdermal drug delivery device involving a carrier containing a dissolved drug. The device also involves a desiccant package that is inert to the carrier, permeable to water vapor, and defines a desiccant compartment containing a desiccant. The device...
12/16/1997
5695743Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
12/09/1997
5693811Process for preparing tetrahdroimidazoquinolinamines
A process for preparing 6, 7, 8, 9-tetrahydro-1H-imidazo›4,5-c!quinolin-4-amines is disclosed. The process involves the reduction of a 1H-imidazo›4,5-c!quinolin-4-amine or of a 6H-imidazo›4,5-c!tetrazolo›1,5-a!quinoline....
12/02/1997
5688520Transmucosal delivery of melatonin for prevention of migraine
A method of reducing the frequency of and/or preventing migraine, involving the step of administering melatonin, preferably to and across a mucosal surface, in an amount and for a time sufficient to increase the period of time between episodes of migraine...
11/18/1997
5688523Method of making a pressure sensitive skin adhesive sheet material
A method of making a pressure sensitive skin adhesive sheet material whereby a coating medium involving a liquid and a polymer is applied to a base layer of a polymer, and the liquid is allowed to diffuse into the base layer....
11/18/1997
5681545Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
10/28/1997
5674473Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
10/07/1997
5669376Aerosol actuator having a linearly arranged canister receiving cavity, valve stem receptacle, orifice, and deagglomeration chamber
An actuator for use in inhalation therapy comprising a nozzle .block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formula...
09/23/1997
5655523Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation
An inhalation device for dry powder containing a chamber capable of receiving a dose of powdered medicament. The chamber is in communication with a patient port in the form of a mouthpiece or nasal adapter. The inhalation device also contains a deagglomer...
08/12/1997
5653961Butixocort aerosol formulations in hydrofluorocarbon propellant
Pharmaceutical solution aerosol formulations of butixocort propionate as the sole active drug agent and a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and a mixture thereof....
08/05/1997
5648516Fused cycloalkylimidazopyridines
6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon (଱) biosynthesis in human cells, their pharmaceutical compositions containing such compounds and methods of inducing interferon (଱) biosynthesis and...
07/15/1997
5644063Imidazo[4,5-c]pyridin-4-amine intermediates
Imidazo[4,5-c]pyridin-4-amines that induce interferon (଱) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (଱) biosynthesis involving the use of such compo...
07/01/1997
5639469Transmucosal delivery system
A device for delivering a heparinic anticoagulant across a mucosal surface in order to achieve or maintain a therapeutically effective blood level of the heparinic anticoagulant. The device involves a matrix containing a therapeutically effective amount o...
06/17/1997
5627281Intermediate compounds of fused cycloalkylimidazopyridines
6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines and their intermediate compounds are described. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (଱) biosynthesis and ...
05/06/1997
5614210Transdermal device for the delivery of alfuzosin
A transdermal drug delivery device involving an acrylate or methacrylate based adhesive copolymer, a skin penetration enhancer, and a therapeutically effective amount of alfuzosin....
03/25/1997
5612377Method of inhibiting leukotriene biosynthesis
A method of inhibiting leukotriene biosynthesis, involving administering a compound of the formula: ##STR1## wherein M, R, R', R", and n are as defined herein. Also, a pharmaceutical composition involving such a compound and the use of such compounds...
03/18/1997
5605674Medicinal aerosol formulations
A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane....
02/25/1997
56058991-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi...
02/25/1997
5602256Process for 1H-imidazo[4,5-C]quinolines
A process for the preparation of 1-substituted,4-substituted-1H-imidazo-[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates....
02/11/1997
5585111Transdermal delivery device
A transdermal drug delivery device involving a backing bearing at least one adhesive layer of an acrylate copolymer and a therapeutically effective amount of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole. The device optionally further involves (i) a s...
12/17/1996
5578727Process for 1H-imidazo[4,5-c]quinolines
A process for the preparation of 1-substituted,4-substituted-1H-imidazo-[4,5-c]quinolines, intermediates in the preparation of such compounds, and processes for the preparation of such intermediates....
11/26/1996
5569450Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid....
10/29/1996
5533498Aerosol actuator having a linearly arranged canister receiving cavity, valve stem receptacle, orifice, and deagglomeration chamber
An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulat...
07/09/1996
5527824Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis
Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed....
06/18/1996
55256121-substituted 1H-imidazo-[4,5-c]quinolin-4-amines
1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use....
06/11/1996
 
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