Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 5446153 | Intermediates for imidazo[4,5-c]pyridin-4-amines Imidazo[4,5-c]pyridin-4-amines that induce interferon () biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon () biosynthesis involving the use of such compo... | 08/29/1995 |
| 5444065 | Fused cycloalkylimidazopyridines as inducer of interferon biosynthesis 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon () biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon () bio... | 08/22/1995 |
| 5439670 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 08/08/1995 |
| 5416113 | Substituted di-t-butylphenols Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents.... | 05/16/1995 |
| 5400920 | One-time fill aerosol valve A valve for delivering a metered dose of a medicinal aerosol formulation. The valve has a filling state, a filled state, a metering state, and a dispensing state. A metering chamber is formed when the device is taken from the filled state to the metering ... | 03/28/1995 |
| 5395937 | Process for preparing quinoline amines A process that involves reacting a 3-nitroquinoline-2,4-disulfonate with an amine or a substituted amine to selectively aminate at the 4-position to yield 1H-imidazo[4,5-c]quinolin-4-amines is disclosed.... | 03/07/1995 |
| 5393362 | Method for improving adhesion to metal A method of applying a layer of exogenous inorganic oxide to a metal article which method involves heating a coating of a coupling agent for a temperature and for a time sufficient to convert the coating to a layer of exogenous inorganic oxide. Also a met... | 02/28/1995 |
| 5389640 | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermedi... | 02/14/1995 |
| 5385736 | Transdermal melatonin delivery system A pressure sensitive adhesive coated sheet material for delivering melatonin through the skin. The sheet material has a flexible backing bearing a pressure sensitive adhesive coating involving an acrylic copolymer, melatonin, 2-(2-ethoxyethoxy)ethanol, an... | 01/31/1995 |
| 5380760 | Transdermal prostaglandin composition Transdermal drug formulations containing a prostaglandin, optionally a lipophilic excipient, and a polyisobutylene pressure sensitive adhesive.... | 01/10/1995 |
| 5372819 | Tramsdermal drug delivery device Polymer blends containing a very low density polyethylene copolymer of ethylene and 1-butene, 1-hexene, or 1-octene and about 15 to about 600 parts by weight of a linear low density polyethylene copolymer of ethylene and 1-octene, based on 100 parts by we... | 12/13/1994 |
| 5367076 | Process for imidazo[4,5-C]quinolin-4-amines A process is disclosed for preparing 1-substituted-1H-imidazo[4,5-c]quinolin-4-amines. The process involves reacting a 1-substituted-1H-imidazo[4,5-c]quinoline-5-oxide with an acylating agent and reacting the product thereof with an aminating agent.... | 11/22/1994 |
| 5352784 | Fused cycloalkylimidazopyridines [6,7]-propylene-, -butylene- or -pentylene-fused imidazopyridin-4-amines that induce interferon () biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon () bi... | 10/04/1994 |
| 5348730 | Method for preparing medicinal aerosol formulation containing coated medicament A method for preparing a self-propelling, powder dispersing aerosol composition comprising at least 0.0001% by weight of a finely-divided solid medicament coated with a non-perfluorinated surface active dispersing agent which constitutes at least 0.0001% ... | 09/20/1994 |
| 5347998 | Breath actuated inhaler having an electromechanical priming mechanism An inhalation device for use with a pressurized aerosol canister. The device involves an electromechanical mechanism for applying a priming force to the aerosol canister prior to or at the start of inhalation. The device also involves a blocking mechanism... | 09/20/1994 |
| 5347036 | Substituted di-t-butylphenols Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents.... | 09/13/1994 |
| 5346905 | 1-substituted 1H-imidazo-[4,5-C]quinolin-4-amines 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.... | 09/13/1994 |
| 5290539 | Device for delivering an aerosol A device for delivering an aerosol, comprising: a casing member, a valve stem, and a diaphragm, wherein the diaphragm comprises a thermoplastic elastomer comprising a ethylene/1-butene copolymer. Also disclosed are sealing members comprising such an elast... | 03/01/1994 |
| 5275212 | Aerosol filling method A process for preparing a medicinal aerosol formulation containing a propellant that is gaseous at standard temperature and pressure and filling the formulation into a metered dose aerosol canister. The process involves mixing the propellant and the drug ... | 01/04/1994 |
| 5268376 | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.... | 12/07/1993 |
| 5266575 | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines 2-Ethyl 1H-imidazo[4,5-c]quinolin-4-amines, which are active as immunomodulators and antiviral agents, and intermediates in the preparation of such compounds, pharmaceutical compositions and pharmacological methods of use.... | 11/30/1993 |
| 5264219 | Transdermal drug delivery backing Polymer blends containing a very low density polyethylene copolymer of ethylene and 1-butene, 1-hexene, or 1-octene and about 15 to about 600 parts by weight of a linear low density polyethylene copolymer of ethylene and 1-octene, based on 100 parts by we... | 11/23/1993 |
| 5244677 | Application system for drug containing microemulsions The invention deals with devices, in particular with bandage strips, for a transdermal delivery of drugs to patients, whereby the drug formulations include highly viscous preparations, topical solutions of a low viscosity and micro-emulsions of a low visc... | 09/14/1993 |
| 5238944 | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological methods... | 08/24/1993 |
| 5225201 | Salsalate tablet A salsalate tablet containing hydroxypropyl cellulose as a binder substantially uniformly dispersed in the tablet. The tablet has good mechanical strength, exhibits a relatively low incidence of capping, and does not require a discrete outer film coating ... | 07/06/1993 |
| 5225183 | Medicinal aerosol formulations A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.... | 07/06/1993 |
| 5223261 | Transdermal estradiol delivery system A pressure-sensitive adhesive sheet material for delivering estradiol to skin, the sheet material comprising a backing with a layer of a pressure-sensitive adhesive adjacent thereto, said pressure-sensitive adhesive layer comprising a pressure-sensitive a... | 06/29/1993 |
| 5192548 | Device A sheet material comprising discrete depressions which are at least partially filled with micronized medicament and which are useful as or in a drug delivery device. This sheet material is useful in devices which provide for aerosolization of the medicame... | 03/09/1993 |
| 5190795 | Method for improving adhesion to metal A method of applying a layer of exogenous inorganic oxide to a metal article which method involves heating a coating of a coupling agent for a temperature and for a time sufficient to convert the coating to a layer of exogenous inorganic oxide. Also a met... | 03/02/1993 |
| 5175296 | Imidazo[4,5-c]quinolin-4-amines and processes for their preparation A process and intermediates for preparing 1-substituted-1H-imidazo[4,5-c]quinolin-4-amines. The process involves reacting a 1-substituted-1H-imidazo[4,5-c]quinoline-5N-oxide with an isocyanate and hydrolysing the product thereof. Also, a process for ... | 12/29/1992 |
| 5166343 | Triazolo[1,5-c]pyrimido[1,4]-azines as bronchodilators Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]azines have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic in... | 11/24/1992 |
| 5147938 | Acrylate adhesives containing polymerizable fluorochemical surfactants Pressure-sensitive acrylate-based adhesive copolymers comprising polymerized acrylate units and polymerized fluorochemical surfactant units and a process for preparing same. Also prepolymeric compositions comprising the monomeric components of an acrylate... | 09/15/1992 |
| 5115803 | Aerosol actuator providing increased respirable fraction An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a conduit chamber, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of ... | 05/26/1992 |
| 5113860 | Non-invasive transmucosal drug level monitoring method Non-invasive transmucosal drug monitoring methods involving devices comprising an acid-functional polymeric resin dispersed substantially throughout a hydrophobic support matrix. The device when adhered to a mucosal surface can absorb some chemicals in am... | 05/19/1992 |
| 5108433 | Tensioning means for prosthetic devices This invention provides improved prosthetic devices for the replacement of a ligament or a tendon. The tension borne by the prosthetic ligament or tendon can be readily increased or decreased without disturbing the attachment of the device to bone and wit... | 04/28/1992 |
| 5103037 | Substituted di-t-butylphenols Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosyn... | 04/07/1992 |
| 5100320 | Dental packaging material and cartridge A cartridge made of a material that does not to a significant extend absorb polar components from a dental composition stored therein. The force required to extrude a dental composition from the cartridge increases less over time in a cartridge of the inv... | 03/31/1992 |
| 5089493 | Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]-azines have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic i... | 02/18/1992 |
| 5089413 | Method and apparatus for culturing with microbiological dry culture medium A device useful for growing aerobic microorganisms, particularly molds. The device employs a relatively small amount of water-reconstitutable medium that can be sealed in order to prevent desiccation and contamination of the medium yet still provide an ad... | 02/18/1992 |
| 5069204 | Inhaler An inhalation device comprising: (i) a breath-actuated inhaler comprising a medicament reservoir mounted within a housing which comprises a mouthpiece and breath-actuation means which prevents dispensing from the reservoir until a patient inhales through ... | 12/03/1991 |
