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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 7807158 | Antibodies against IL-13 receptor alpha1 and uses thereof The instant specification discloses an antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of this antibody is selected from t... | 10/05/2010 |
| 7776590 | Stable cell lines expressing hERG A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided. ... | 08/17/2010 |
| 7615216 | Antibodies against CCR5 and uses thereof Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease. ... | 11/10/2009 |
| 7501496 | Anti-OX40L antibodies This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a ben... | 03/10/2009 |
| 7491821 | Inhibitors of P2X Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders: wherein R1 is —C(═S)CH3, pyridyl, pyrimid... | 02/17/2009 |
| 7476676 | Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3β This invention relates to the use of inhibitors of glycogen synthase kinase-3β to increase bone formation. ... | 01/13/2009 |
| 7456185 | Substituted quinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and R7 | 11/25/2008 |
| 7449472 | Methods of inhibiting p38 with substituted bicyclic pyrimidines The present invention discloses compounds corresponding to the formula wherein A, X, Y, R, R1 and R2 are as defined within, pharmaceutical formulations, methods of making and uses thereof. ... | 11/11/2008 |
| 7439247 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors The present invention discloses compounds corresponding to formula wherein A, R, X, Y, R, R1 and R2 are as defined above, pharmaceutical formulations, methods of making and uses thereof. ... | 10/21/2008 |
| 7410994 | Indole derivatives as anti-inflammatory agents This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other... | 08/12/2008 |
| 7361648 | Heterocyclylakylamines as muscarinic receptor antagonists This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined... | 04/22/2008 |
| 7320987 | 6-Alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or C... | 01/22/2008 |
| 7285561 | Imidazo-substituted compounds as p38 kinase inhibitors The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, m... | 10/23/2007 |
| 7285559 | Imidazo-substituted compounds as p38 kinase inhibitors The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, m... | 10/23/2007 |
| 7238698 | Substituted quinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and ... | 07/03/2007 |
| 7196097 | 6-alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloallkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or ... | 03/27/2007 |
| 7189731 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6 is hydrogen or lower alkyl; R7 is hydroge... | 03/13/2007 |
| 7186840 | Quinoline derivatives as anti-inflammatory agents This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR | 03/06/2007 |
| 7157580 | Aminopyrimidine and aminopyridine anti-inflammation agents Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein ... | 01/02/2007 |
| 7141584 | 2-(substituted-phenyl)amino-imidazoline derivatives This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) ... | 11/28/2006 |
| 7141562 | Substituted benzoxazinones and uses thereof Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO2— or —(CRaRb)r—, n is 1 or 2, R... | 11/28/2006 |
| 7135470 | Thienopyridazines as IKK inhibitors The invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R1 are as defined herein. Also provided are compositions comp... | 11/14/2006 |
| 7135476 | Spiro tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, R | 11/14/2006 |
| 7105525 | 6-alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or C... | 09/12/2006 |
| 7105666 | Synthesis of purine derivatives The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine s... | 09/12/2006 |
| 7091200 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is... | 08/15/2006 |
| 7091347 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors The present invention discloses compounds corresponding to formula wherein A, R, X, Y, R, R1 and R2 are as defined above, pharmaceutical formulations, methods of making and uses thereof. | 08/15/2006 |
| 7081462 | Imidazo-substituted compounds as p38 kinase inhibitors The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, m... | 07/25/2006 |
| 7081531 | Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists Compounds having the formula (I), Ar—(F)-(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridg... | 07/25/2006 |
| 7074939 | Indole derivatives as anti-inflammatory agents This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; an... | 07/11/2006 |
| 7074763 | Stable formulations of nerve growth factor Aqueous formulations of nerve growth factor suitable for lyophilization and subsequent reconstitution in which nerve growth factor is admixed with sugars and buffer are provided. ... | 07/11/2006 |
| 7071177 | P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ... | 07/04/2006 |
| 7049317 | CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein R1–R4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containi... | 05/23/2006 |
| 7049325 | Quinoline derivatives as anti-inflammatory agents This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR | 05/23/2006 |
| 7019007 | CCR-3 receptor antagonists (I) The invention provides compounds of Formula (I): wherein: R1–R4, A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions c... | 03/28/2006 |
| 6984643 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists Compounds of Formula (I): wherein Ar1 is aryl; Ar2 is hydrogen, cycloalkyl, aryl or heteroaryl; Z is —C(═O) or a single bond; R1, R2, R3, R4 and R | 01/10/2006 |
| 6977265 | Piperidine CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein: R1-R5, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions co... | 12/20/2005 |
| 6965030 | 6-alkoxy-pyrido-pyridine The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or CH; and... | 11/15/2005 |
| 6951918 | Peptidic procollagen C-proteinase inhibitors This invention relates to compounds of Formula (I) wherein R1-R7, A, Z and n are as described in the Summary of the Invention that are inhibitors of procollagen C-proteinase, pharmaceutical compos... | 10/04/2005 |
| 6949560 | Imidazo-substituted compounds as p38 kinase inhibitors The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods... | 09/27/2005 |
