Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| RE39150 | Composition for creating vascular occlusions A composition including 2-hexyl cyanoacrylate and goal is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked. ... | 06/27/2006 |
| 7011973 | Regulatory sequences capable of conferring expression of a heterologous DNA sequence in endothelial cells in vivo and uses thereof Described are recombinant DNA molecules comprising the regulatory sequences of an intron of the Endothelial Growth Factor (VFGF) receptor-2 gene (Flk-1) or of a gene homologous to the Flk-1 gene, being capable of conferring expression of a heterologous DNA sequence ... | 03/14/2006 |
| 6949338 | Methods and kits for obtaining and analyzing skin samples for the detection of nucleic acids Disclosed is a method for removing polynucleotide from the skin. This polynucleotide can be used to detect dermatitis and distinguish an irritant reaction from an allergic reaction by characterizing the polynucleotide according to the polypeptide which it encodes. A... | 09/27/2005 |
| 6921533 | Method of using monoclonal antibodies against leukocyte adhesion receptor β-chain Monoclonal antibodies and method for ameliorating an immune response disorder. The monoclonal antibodies are specific for an epitope present on the leukocyte adhesion receptor β-chain. ... | 07/26/2005 |
| 6916917 | Chimeric pro-caspases and methods of using same The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a ... | 07/12/2005 |
| 6911528 | Hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G↓CF site recognized by the autoproteolytic do... | 06/28/2005 |
| 6906035 | Antimicrobial cationic peptides A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods f... | 06/14/2005 |
| 6890745 | Protease specific cleavable luciferases and methods of use thereof Provided are methods and compositions useful in detecting protease activity in a sample, as well as methods of identifying agents that modulate protease activity. The methods and compositions provide a modified luciferase polynucleotide sequence and a luciferase pol... | 05/10/2005 |
| 6890485 | High throughput chemical handling system A high throughput chemical handling system includes a chemical storage module, a transport module, and one or more liquid handling modules. The transport module may implement parallel chemical transport, and the system may include a plurality of asynchronously opera... | 05/10/2005 |
| 6883372 | Airborne gravity gradiometers This invention concerns gravity gradiometers for airborne surveys for minerals. The gravity gradiometer comprises an inertially stabilized platform, a rotor that is between 0.4 and 1.5 m in diameter mounted in the stabilized platform, and between twelve and seventy ... | 04/26/2005 |
| 6884870 | Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells The invention provides a fusion protein including a reporter polypeptide, a linker polypeptide comprising a protease cleavage site, and a repressor polypeptide. The repressor polypeptide represses the activity of the reporter polypeptide by conferring a specific loc... | 04/26/2005 |
| 6878567 | Method and apparatus for fabrication of passivated microfluidic structures in semiconductor substrates A method and apparatus for fabrication of passivated microfluidic structures is disclosed. The method includes providing a substrate having a microfluidic structure formed therein. The microfluidic structure is embedded by an embedding layer. The method further incl... | 04/12/2005 |
| 6872533 | STK15 (STK6) gene polymorphism and methods of determining cancer risk The present invention provides methods for determining cancer susceptibility in a human subject by identifying in a nucleic acid sample from the subject, a nucleotide occurrence of a single nucleotide polymorphism (SNP) of the STK15 gene, including the STK15 Ile31 p... | 03/29/2005 |
| 6872574 | Proteomic analysis The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. ... | 03/29/2005 |
| 6867045 | Method for diagnosis of thrombotic disorders The present invention provides an in vitro method useful for the diagnosis of a thrombotic disorder in a subject, having or at risk of having the disorder. Specifically, the disorder exemplified herein is associated with APC resistant Factor V and Va. The clotting t... | 03/15/2005 |
| 6863888 | Oncoprotein protein kinase An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detec... | 03/08/2005 |
| 6859838 | Media player with programmable playlists An internet-based personalizable broadcast network for viewing information in the form of streaming audio and/or video. The network includes an input for receiving streaming media content, organized into a plurality of news channels. The network includes some type o... | 02/22/2005 |
| 6858208 | Growth differentiation factor-8 A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated i... | 02/22/2005 |
| 6852492 | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DN... | 02/08/2005 |
| 6849395 | Gene cluster screening of clones having DNA from mixed populations of organisms Disclosed is a process of screening clones having DNA from an uncultivated microorganism for a specified protein, e.g. enzyme, activity by screening for a specified protein, e.g. enzyme, activity in a library of clones prepared by (i) recovering DNA from a DNA popul... | 02/01/2005 |
| 6849717 | Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon Nematodes, such as Caenorhabditis elegans, that express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in th... | 02/01/2005 |
| 6846663 | Regulation of target protein activity through modifier proteins The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain an... | 01/25/2005 |
| 6846644 | Oncoprotein protein kinase An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detec... | 01/25/2005 |
| 6840995 | Process for producing fast-setting, bioresorbable calcium phosphate cements A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solu... | 01/11/2005 |
| 6838238 | Morphatides: novel shape and structure libraries This invention provides a method for identifying one or more complexes from a library of complexes, wherein said complex or complexes are selected for their ability to perform a preselected or desired function on a target molecule or by having a pre-selected structu... | 01/04/2005 |
| 6835911 | Method and system for optically sorting and/or manipulating carbon nanotubes A method, apparatus, and system for optically sorting and/or manipulating carbon nanotubes by creating an optical dipole trap with a focused light source (e.g., a laser) are described in detail herein. In one representative embodiment, light from the light source ma... | 12/28/2004 |
| 6835717 | β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted ... | 12/28/2004 |
| 6835541 | Aberrantly methylated genes as markers of breast malignancy The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid rece... | 12/28/2004 |
| 6835193 | Methods for controlled depth injections into interior body cavities A flexible tissue injection catheter is used to accomplish injections at a precisely controlled depth of precisely controlled volumes of a therapeutic or diagnostic agent into an interior body cavity, such as the epicardium or myocardium of the heart. In one embodim... | 12/28/2004 |
| 6833445 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication. ... | 12/21/2004 |
| D500062 | Can compressor and storage appliance housing with handle | 12/21/2004 |
| 6832380 | Client-server application partitioning with metering technique for distributed computing Client-server software partitions Windows applications into multi-media and other less-observable instructions such that client may run audio/visual-related commands remotely, thereby appearing to client-user as when application were run solely by central server. Cl... | 12/14/2004 |
| 6831160 | Method of affinity purifying proteins using modified bis-arsenical fluorescein The present invention features methods for purifying polypeptides of interest using a modified Fluorescein arsenical helix binder (FlAsH) compound immobilized on a solid support. An exemplary FlAsH target sequence motif is also presented. Examples of modification of... | 12/14/2004 |
| 6831921 | Wireless internet access system A wireless network access system and method that provides a multiplicity of access point devices, each being capable of relaying information. The upstream network access may include an omni-directional antenna for downstream communications. The wireless network is p... | 12/14/2004 |
| 6825042 | Microplate lid A microplate lid having a substantially flat, generally rectangular top with first and second pairs of opposite sides. A flange depends from the top of the first and second pairs of sides, the flange bearings at least one recess area along each side of the first pai... | 11/30/2004 |
| 6821760 | Methods for producing L-aspartic acid This invention relates to a method for producing L-aspartic acid comprising treating an ammonium fumarate solution with aspartase to generate an ammonium L-aspartate solution; adding fumaric acid to the solution; and then crystallizing L-aspartic acid from the solut... | 11/23/2004 |
| 6818407 | Anti-endotoxic antimicrobial cationic peptides and methods of use therfor A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of ... | 11/16/2004 |
| 6818145 | Antifreeze/coolant composition A durable antifreeze/coolant composition for coolants for the cooling systems of internal combustion engines is disclosed. The composition is excellent in inhibiting corrosion of metal portions, especially iron and aluminum portions and effectively inhibits cavitati... | 11/16/2004 |
| 6815418 | TGF-α polypeptides, functional fragments and methods of use therefor Disclosed are TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand s... | 11/09/2004 |
| 6814933 | Multiwell scanner and scanning method A multiwell plate scanner comprises a detector for measuring an attribute of a sample which is scanned continuously over wells of a multiwell plate. A signal obtained during the scan may be sampled and digitized based on detector position over the multiwell plate. T... | 11/09/2004 |
