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| Number | Title | Issue Date |
| 5543323 | Plasmodium merozoite rhoptries antigenic polypeptides Novel antigenic polypeptides having at least one determinant immunologically cross-reactive with determinants on a polypeptide associated with the rhoptry organelles of the merozoite form of the malaria parasite Plasmodium falciparum are described. Also d... | 08/06/1996 |
| 5541108 | Gluconobacter oxydans strains A process for producing 2-keto-L-gulonic acid which comprises converting L-sorbose and/or D-sorbitol into 2-keto-L-gulonic acid with the aid of a microorganism or its cell free extract, said microorganism belonging to the species Gluconobacter oxydans cap... | 07/30/1996 |
| 5516930 | Intermediates in the production beta aminoalcohols Acid esters of formula, ##STR1## wherein R2 is lower-alkyl, or acid-addition salts thereof useful as intermediates in the production of beta-aminoalcohols.... | 05/14/1996 |
| 5512688 | Sulphonic acid esters which are useful as intermediates in the production of 댪minoalcohols Sulphonic acid esters of formula ##STR1## wherein R1 is lower-alkyl or phenyl, useful as intermediates in the production of ଲ-aminoalcohols.... | 04/30/1996 |
| 5512682 | Nitrile compounds useful as intermediates in the production of beta amino alcohols Nitriles of formula ##STR1## wherein R3 is acetoxy or benzyloxycarbonyl, useful as intermediates in the production of beta-aminoalcohols.... | 04/30/1996 |
| 5495025 | Isoindole compounds which are useful as intermediates The compound of the formula, ##STR1## wherein R4 is hydrogen, lower-alkanoyl or benzyloxycarbonyl and R2 is lower-alkyl or acid-addition salts thereof, useful as intermediates in the production of beta-aminoalcohols.... | 02/27/1996 |
| 5486463 | TNF-muteins The present invention is directed to a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof having selective binding affinity for the human p55-Tumor-Necrosis-Factor-Receptor characterized in that the amino acid sequence of hum... | 01/23/1996 |
| 5479260 | Optical process and apparatus for analysis of substances on sensor surfaces The optical process for analyzing substances is based on the measurement of the propagation properties of optical surface waves on sensor surfaces. In a wave guide layer structure in contact with a sample, guided light waves are decoupled with a grating c... | 12/26/1995 |
| 5478569 | Fat-soluble composition of colloidal fish gelatin Stable, cold water-dispersible, liquid or pulverous compositions of fat-soluble substances which contain fish gelatin as the protective colloid and a method of making same are described.... | 12/26/1995 |
| 5476932 | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives A process for preparing N4-acyl-5'-deoxy-5-fluorocytidine derivatives of formula III: ##STR1## by selective deacylation, wherein R is alkyl, cycloalkyl, alkenyl, aralkyl or aryl, which comprises reacting a compound of formula II, ##STR2## w... | 12/19/1995 |
| 5466708 | Oxetanones Novel compounds of the formula ##STR1## wherein Q, R1 and R2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of formula I which starts from the corr... | 11/14/1995 |
| 5455353 | 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides A process for the production of a ଲ-aminoalcohol 2-[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-decahydro-(4aS,8aS) -isoquinoline-3(S)-carboxamide of the formula ##STR1## via the oxazolidinone corresponding to the aminoalcohol 10, as wel... | 10/03/1995 |
| 5453497 | Process for producing N4 -acyl-5'-deoxy-5-fluorocytidine compounds A novel process for producing derivatives of the anti-tumor agent N4 -acyl-5'-deoxy-5-fluorocytidine using the novel 5'-deoxy-5-fluoro-N4, 2'-0,3'-0-triacylcytidine derivatives as intermediates is provided. 5-Deoxy-1,2,3-tri-0-acyl-³... | 09/26/1995 |
| 5446161 | Amino acid derivatives Compounds of the formula ##STR1## wherein and their pharmaceutically acceptable acid addition salts inhibit proteases of vital origin and can be used as medicaments for the treatment or prophylaxis of viral infections. They can be manufactured accord... | 08/29/1995 |
| 5437989 | Alcohol/aldehyde dehydrogenase from Gluconobacter oxydans DSM 4025 FERM BP-3812 A homogeneous alcohol/aldehyde dehydrogenase isolated from Gluconobacter oxydans DSM 4025 FERM BP-3812 is disclosed. The enzyme is capable in the presence of an electron acceptor, of catalyzing the conversion of L-sorbose to 2-keto-L-gulonic acid via L-so... | 08/01/1995 |
| 5428004 | Compounds useful as dual antagonists of platelet activating factor and leukotriene D4 The invention relates to compounds of the formula ##STR1## wherein R1 is OR6 or NHR7, R6 and R7, which may be, the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl having b... | 06/27/1995 |
| 5422104 | TNF-muteins It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or mor... | 06/06/1995 |
| 5410056 | Method for the production of folic acid The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This di... | 04/25/1995 |
| 5399496 | DNA shuttle vectors for E. coli, Gluconobacter, and Acetobacter Novel shuttle vectors which are useful as shuttle vectors among microorganisms belonging to Escherichia coli, Gluconobacter and Acetobacter comprising one or more marker genes, a replication origin functional in Escherichia coli, a replication origin func... | 03/21/1995 |
| 5393765 | Pharmaceutical compositions with constant erosion volume for zero order controlled release An erodible pharmaceutical composition providing a unique zero order controlled release profile is herein described. The erodible composition contains a therapeutically active substance having a solubility not greater than 80 mg/mL, a hydroxypropyl methyl... | 02/28/1995 |
| 5393760 | Guanidine derivatives Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The co... | 02/28/1995 |
| 5364563 | Powdered aqueous carotenoid dispersions A novel process for producing powdered carotenoid preparations, in which a suspension of a carotenoid in a high-boiling oil is brought into contact with superheated steam during a maximum period of 30 seconds, and subsequently emulsified the liquified sol... | 11/15/1994 |
| 5360908 | Isoquinoline derivatives A process for the preparation of isoquinoline derivatives of the formulas ##STR1## wherein R1 and R2 have the significances herein after set forth in the description, is described. The compounds of formula IV are obtained by asymmetr... | 11/01/1994 |
| 5302590 | Compounds useful as dual antagonists of platelet activating factor and leukotriene D4 The invention relates to compounds of the formula ##STR1## wherein R1 is OR6 or NHR7, R6 and R7, which may be, the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl having b... | 04/12/1994 |
