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| Number | Title | Issue Date |
| 5560377 | Dental floss The present disclosure relates to an improved floss implement comprising a composite of a multifilament yarn bonded to an extruded monofilament. Both elements are made of polymer compounds, preferably nylon, to provide desired ease of use of the monofilam... | 10/01/1996 |
| 4871757 | Heterocyclic compounds The invention is concerned with novel triazole derivatives of the formula ##STR1## wherein R1 is optionally substituted phenyl and R2 signifies substituted phenyl, as more precisely defined in the description, and R3 ... | 10/03/1989 |
| 4870219 | Novel tetrahydronaphthalene and indane derivatives Novel styryl-tetrahydromaphythalene and indane derivatives useful for treating neoplasms and dermatoses.... | 09/26/1989 |
| 4868111 | Gram-positive expression control sequences New gram-positive expression control DNA sequences useful in the expression of pro- or eukaryotic proteins in gram-positive organisms are provided having in the downstream direction of transcription a transcription initiation DNA sequence of gram-negative... | 09/19/1989 |
| 4865970 | Method of detecting ribosomal protein antibodies in systemic lupus erythematosus This invention provides methods for the diagnosis of systemic lupus erythematosus in patients, the sera of which contain antibodies reactive against ribosomal proteins P0, P1 and P2. A peptide containing an amino acid sequence corresponding to the carboxy... | 09/12/1989 |
| 4863969 | Treatment of premalignant lesions and certain malignant tumors 1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-(-methylstyryl)naphthalene possesses antihyperplastic, antimetaplastic, antineoplastic tumor-preventative and tumor-therapeutic properties and can accordingly be used in the treatment of precancerous or prem... | 09/05/1989 |
| 4861890 | Isomerization A process for producing chiral enamines by isomerizing a beta, gamma unsaturated amine with a rhodium-diphosphine complex with the addition of an achiral triarylphosphine and, if desired, hydrolyzing the compound of the enamine I obtained to the correspon... | 08/29/1989 |
| 4857648 | Isoquinoline derivatives The invention is concerned with novel isoquinoline derivatives of the formula ##STR1## wherein R1 is hydrogen, lower alkyl, lower alkoxy, aryl, aryloxy, aryl-lower alkyl or aryl-lower alkoxy and R2 is phenyl or substituted pheny... | 08/15/1989 |
| 4855085 | Asymmetric synthesis of natural vitamin E An asymmetric synthesis for Vitamin E in an optically active pure form for 4-(2,5-diloweralkanoyloxy)-3,4,6-trimethylphenyl-butan-2-one and intermediates therein.... | 08/08/1989 |
| 4853472 | Vitamin E intermediates A process for producing natural vitamin E and intermediates in this process.... | 08/01/1989 |
| 4851585 | Vitamin E intermediates Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.... | 07/25/1989 |
| 4849347 | Colorimetric biological assay Lactic acid produced by cells in culture is detected and used in a bioassay to determine cell growth and vitality. Lactic acid is detected by coupling the lactate dehydrogenase conversion of lactic acid to pyruvic acid to a reaction using micotinamide ade... | 07/18/1989 |
| 4841070 | Sulfinyl-ascorbic acid useful as an anti-oxidant The novel 5,6-sulfinyl-L-ascorbic acid and its stereoisomers, their manufacture by sulfinylating L-ascorbic acid or corresponding stereoisomers, compositions having oxidation-inhibiting properties which contain 5,6-sulfinyl-L-ascorbic acid or a stereoisom... | 06/20/1989 |
| 4841045 | Synthesis of vinblastine and vincristine type compounds A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.... | 06/20/1989 |
| 4839382 | Anticoccidial compositions Compositions comprising a mixture of the antibiotic frenolicin B with one of the ionophorous polyether anticoccidial agents, useful for the treatment and prevention of coccidiosis in animals and methods of treating coccidiosis ar disclosed.... | 06/13/1989 |
| 4837311 | Anti-retroviral compounds A-B-C wherein A and C are each independently 2',3' dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.... | 06/06/1989 |
| 4833259 | Light screening agents The novel sunscreen agents which are esters, namely esters of p-methoxy-cinnamic acid with d,1--tocopherol, pantolactone or panthenol.... | 05/23/1989 |
| 4833073 | Immunoassay for tetrahydrocannabinol metabolites Novel cannabinol derivatives are provided which can be used in improved immunoassays for the detection in blood or urine samples of cannabinol metabolites.... | 05/23/1989 |
| 4833245 | Heterocyclic compound The invention is concerned with novel heterocyclic compounds of the formula ##STR1## wherein R is C1-12 -alkyl, C3-12 -alkenyl, C3-12 -alkynyl or C3-8 -cycloalkyl and X signifies oxygen or sulfur, and none of th... | 05/23/1989 |
| 4831185 | Asymmetric synthesis of natural vitamin E An asymmetric synthesis for Vitamin E in an optically active pure form for 4-(2,5-diloweralkanoyloxy)-3,4,6-trimethylphenyl-butan-2-one and intermediates therein.... | 05/16/1989 |
| 4831151 | Antimicrobial imidazolium derivatives Compounds of the formula ##STR1## wherein the various substituents are defined hereinbelow and the pharmaceutically acceptable acid addition salts thereof, possess pharmacological properties. In particular, they possess antibacterial, antimycoti... | 05/16/1989 |
| 4826830 | Topical application of glyciphosphoramide Topical application of glyciphosphoramide for treatment of cancerous ulcerations and tumor conditions are disclosed.... | 05/02/1989 |
| 4827004 | Isoprene derivatives Novel Isoprene Derivatives which have mucosa-protective and gastric acid secretion-inhibiting properties and are useful for combatting ulcers both by treating and as a prophylaxis against gastric and/or duodenal ulcers.... | 05/02/1989 |
| 4824972 | Hydroquinone derivatives Compounds of the general formula ##STR1## wherein R represents an ether protecting group and R1 is a group of (a)-(d) useful as intermediates.... | 04/25/1989 |
| 4824971 | 2-allylchromans Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.... | 04/25/1989 |
| 4822890 | Method for the production of amino terminus protected naturally occurring amino acids A method for the production of substantially 100% pure N-urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protec... | 04/18/1989 |
| 4816566 | Polypeptides having interferon activity A polypeptide having interferon activity which has an amino acid sequence corresponding to an amino acid sequence of an interferon selected from rIFN-, hybrid rIFN-, rIFN-ଲ and rIFN-γ interferons in which at least one cysteine residue... | 03/28/1989 |
| 4812164 | Herbicidal heterocyclic compounds The invention is concerned with novel C1-4 -alkyl, C2-4 -alkenyl and C3 or 4 -alkynyl enol ethers of 3-aryluracils of the formula ##STR1## wherein R1, R2, R3, R4, R5 a... | 03/14/1989 |
| 4810645 | Microbial production of mature human leukocyte interferon K and L This invention relates to the microbial production, via recombinant DNA technology, of new human leukocyte interferons, Le IF-K and Le IF-L for use in the treatment of viral and neoplastic diseases, and to the means and end products of such production.... | 03/07/1989 |
| 4808701 | Cyclic peptides having appetite regulating activity Cyclic peptides with appetite regulating activity.... | 02/28/1989 |
| 4808734 | 16-cycloalkyl-7-fluoro-prostacyclins 16-Cycloalkyl-7-fluoro prostacyclins having a 16 lower alkyl or fluoro substituent useful as blood platelet anti-aggregating agent, vasodilators, cyto protective lowering agents, anti-ulcerogenic agent and for treating peripheral vascular diseases such as... | 02/28/1989 |
| 4806661 | Chromanemelonate esters Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.... | 02/21/1989 |
| 4801685 | Microbial production of mature human leukocyte interferon K and L This invention relates to the microbial production, via recombinant DNA technology, of new human leukocyte interferons, Le IF-K and Le IF-L for use in the treatment of viral and neoplastic diseases, and to the means and end products of such production.... | 01/31/1989 |
| 4801724 | Vitamin E intermediate A process for producing alpha-tocopherol and intermediates in this process.... | 01/31/1989 |
| 4800168 | Two reagent system for the colorimetric determination of chloride ions in body fluids A method for measuring chloride ion concentration in a sample of body fluid, e.g., serum or plasma is described in which a sample blank is made in the same cuvette after the test measurement has been made.... | 01/24/1989 |
| 4792616 | Diaryl ethers Novel diaryl ethers of the formula ##STR1## wherein A is CR3 or N and R1, R2, R3, R4, R5, n and R6 are as defined hereinafter, processes for their preparation, herbicidal co... | 12/20/1988 |
| 4789750 | 2-(trimethyl-tridecenyl)-tetramethylchroman intermediates for vitamin E 6-Etherified hydroxy -2-(4',8',12'-trimethyl-5'-tridecenyl)-2,5,7,8-tetramethylchromans with an oxo or hydroxy substituent at the 2' position which may be substituted with an arylsulfonyl or a carboxyalkyl at the 3' position and containing a single o... | 12/06/1988 |
| 4788210 | 1,2,4-Triazole compounds The invention is concerned with novel heterocyclic compounds of the formula ##STR1## wherein R1, R2 and R3 are as hereinafter set forth, and their acid addition salts, processes for the preparation of these compounds,... | 11/29/1988 |
| 4788213 | Benzopyranyl and benzothiopyranyl compounds and uses Novel p-[2(4,4-dimethyl-6-heterophenyl)substituted phenyl derivatives and salts thereof which are useful for combatting neoplasms and dermatoses including oral and topical compositions containing said derivatives which are suitable for such uses.... | 11/29/1988 |
| 4780251 | Phenyl substituted-2,4,6,8-nonatetraenoic acid The compounds 9-phenyl-3,7-dimethyl-2,4,6,8-nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modi... | 10/25/1988 |
