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| Number | Title | Issue Date |
| 8173020 | Method for removing contaminants from water using a membrane biofilm reactor Apparatus and methods for water treatment are described, particularly for the simultaneous removal of nitrate, perchlorate, and other organic contaminates from contaminated water using a membrane biofilm reactor (MBfR). ... | 05/08/2012 |
| 8153604 | CNS-tumor treatment method and composition A method, aerosol composition, and aerosolizing device for treating a brain tumor in a subject are disclosed. The method includes intranasally administering to the subject, an amount of a telomerase inhibitor, such as an oligonucleotide telomerase inhibitor, effecti... | 04/10/2012 |
| 7998938 | Cancer treatment by combined inhibition of proteasome and telomerase activities A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obt... | 08/16/2011 |
| 7931807 | Method for removing contaminants from ground water Apparatus and methods for water treatment are described, particularly for the simultaneous removal of nitrate, perchlorate, and other organic contaminates from contaminated water using a membrane biofilm reactor (MBfR). ... | 04/26/2011 |
| 7871568 | Rapid test apparatus Provided herein are methods and devices for rapid testing of solid, semi-solid, or liquid specimens, such as stool, blood, urine, saliva, or swab specimens of the cervix, urethra, nostril, and throat, and for environmental testing. ... | 01/18/2011 |
| 7834138 | Segmented polymers and their conjugates Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are us... | 11/16/2010 |
| 7815801 | Removal of selenium in contaminated wastewater streams Compositions and methods for the removal of selenium species from water containing high-salt concentrations and/or petroleum contaminants are described. The compositions and methods use a selenium-reducing microorganism adapted to adverse environments. ... | 10/19/2010 |
| 7794656 | Device for handling and analysis of a biological sample An apparatus for detection of an analyte of interest in a solid, semi-solid, or liquid biological sample, using a lateral flow assay test strip, is described. The apparatus minimizes sample handling and manipulation upon introduction of the sample into a sample-rece... | 09/14/2010 |
| 7595007 | Amino acid and carbohydrate polymers for use in soil retention, water conservation, water clarification, and dust control Water-soluble amino acid copolymers, modified polysaccharides, acrylamide polymers, and combinations thereof, are described, for uses including flocculation of solids, particularly flocculation of soil, such as in an agricultural setting. Also described are methods ... | 09/29/2009 |
| 7595002 | Use of amino acid and carbohydrate polymers in soil retention, water conservation, and water clarification Water-soluble amino acid copolymers, modified polysaccharides, acrylamide polymers, and combinations thereof are described for use in flocculation of solids, particularly flocculation of soil, preferably in agricultural settings. ... | 09/29/2009 |
| 7547509 | Cyanovirin variant-polymer conjugates The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof, and methods of preparing such conjugates. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water solu... | 06/16/2009 |
| 7417069 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF... | 08/26/2008 |
| 7282370 | System and apparatus for sequential processing of analytes An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside... | 10/16/2007 |
| 7267941 | Cyanovirin variant-polymer conjugates The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugate... | 09/11/2007 |
| RE39793 | Compositions for sorting polynucleotides The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each consist of a plurality of subunits 3 to 6 nucleotides in length selected fr... | 08/21/2007 |
| 7115583 | Microbubble compositions and methods for oligonucleotide delivery The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or ... | 10/03/2006 |
| 7098348 | Triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl... | 08/29/2006 |
| 7091305 | Copolymers of amino acids and methods of their production Disclosed are copolymers based on aspartic acid or its precursor molecules and methods of their production. The copolymers are water-soluble over a wide range of composition and molecular weight. Their preparation involves conversion of a polysuccinimide to copolyme... | 08/15/2006 |
| 7053170 | Preparation of high molecular weight polysuccinimides Described are methods of production of polysuccinimides having molecular weights up to 200,000 daltons and higher. The polysuccinimides of the invention are essentially unbranched and uncrosslinked. They can be modified by crosslinking, ring-opening, and/or other fu... | 05/30/2006 |
| 7049431 | Antisense antibacterial cell division composition and method Antisense oligomers directed to bacterial cell division and cell cycle-encoding nucleic acids are capable of selectively modulating the biological activity thereof, and are useful in treatment and prevention of bacterial infection. The antisense oligomers are substa... | 05/23/2006 |
| 7045311 | Whole cell assay systems for cell surface proteases The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirec... | 05/16/2006 |
| 7019151 | Triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R... | 03/28/2006 |
| 7005521 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions provide a versatile and low-cos... | 02/28/2006 |
| 6982092 | Method of complexing a nucleic acid with a lipid-conjugated polyamide In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologica... | 01/03/2006 |
| 6943259 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CH... | 09/13/2005 |
| 6919456 | Catalytic compositions and methods for asymmetric aldol reactions Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of formula I,... | 07/19/2005 |
| 6897023 | Method for determining relative abundance of nucleic acid sequences Disclosed are methods for identifying nucleic acid sequences which are of different abundances in different nucleic acid source populations, e.g. differentially expressed genes or genomic variations among individuals or populations of individuals. In one embodiment,... | 05/24/2005 |
| 6881581 | High-density lipoprotein assay device and method An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design is such that removal of non-HDL lipoproteins from a sample and assay of HDL cholesterol in the sample occur without inter... | 04/19/2005 |
| 6875747 | Antisense to c-myc for treatment of polycystic kidney disease A method of treating polycystic kidney disease by administering an oligonucleotide antisense to c-myc is described. The antisense oligonucleotide is preferably a morpholino oligonucleotide. ... | 04/05/2005 |
| 6846921 | Chimeric antisense oligonucleotides and cell transfecting formulations thereof Chimeric oligonucleotide of the formula 5′-W—X1—Y—X2—Z-3′, where W represents a 5′-O-alkyl nucleotide, each of X1 and X2 represents a block of seven to twelve phosphodiester-linked 2′-O-alkyl ribonucleotide... | 01/25/2005 |
| 6825313 | Copolymers of amino acids and methods of their production Disclosed are copolymers based on aspartic acid or its precursor molecules and methods of their production. The copolymers are water-soluble over a wide range of composition and molecular weight. Their preparation involves conversion of a polysuccinimide to copolyme... | 11/30/2004 |
| 6818113 | Microfluidic device with sample injector and method of using A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions and first, second, and third s... | 11/16/2004 |
| 6784291 | Splice-region antisense composition and method Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is R... | 08/31/2004 |
| 6747152 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. ... | 06/08/2004 |
| 6677153 | Antisense antibacterial method and composition The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use. More particularly, the invention relates to antisense oligo... | 01/13/2004 |
| 6654505 | System and apparatus for sequential processing of analytes An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar a... | 11/25/2003 |
| 6653460 | Voltage-gated calcium channel antagonist and method A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of ... | 11/25/2003 |
| 6620843 | Anticancer treatment using triptolide prodrugs Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents 5-fluorouracil and irinotecan.... | 09/16/2003 |
| 6610827 | Potassium channel subunit polypeptide and polynucleotide compositions and uses therefor The present invention provides novel potassium channel subunits (denoted Kv-SL1 and Kv-SL2, and collectively as Kv-SL) and polynucleotides which identify and encode them. The invention also provides expression vectors and host cells comprising nucleic aci... | 08/26/2003 |
| 6569893 | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents Compounds which are prodrugs of triptolide or its derivatives, containing an amino acid or oligopeptide moiety, are used for anticancer or immunosuppressive treatment. The compounds are of the structure: ##STR1## where X1 is OH or OR1 | 05/27/2003 |
