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| Number | Title | Issue Date |
| 8137667 | Fully human antibodies against human 4-1BB Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject compris... | 03/20/2012 |
| 8129114 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least... | 03/06/2012 |
| 8067189 | Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators by measuring the level of collagen type IV VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulato... | 11/29/2011 |
| 7932031 | Methods for determining sensitivity to microtubule-stabilizing agents comprising ixabepilone by measuring the level of estrogen receptor 1 Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the mi... | 04/26/2011 |
| 7659384 | Polynucleotides encoding fully human antibodies against human 4-1BB Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject compris... | 02/09/2010 |
| 7601540 | Gamma secretase notch biomarkers The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The ... | 10/13/2009 |
| 7288638 | Fully human antibodies against human 4-1BB Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject compris... | 10/30/2007 |
| 7265260 | Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-indep... | 09/04/2007 |
| 7241565 | Liquid interface configurations for automated patch clamp recording A method of automatically conducting patch clamp testing is provided wherein a liquid interface is utilized. The liquid interface is defined in a liquid suspension between layers of distinct densities such that cells introduced into the liquid suspension float towar... | 07/10/2007 |
| 7225083 | Crystallographic structure of the androgen receptor ligand binding domain The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonis... | 05/29/2007 |
| 7214527 | Compositions and methods for hydroxylating epothilones Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing the... | 05/08/2007 |
| 7214493 | Polynucleotides encoding humanized antibodies against human 4-1BB A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effe... | 05/08/2007 |
| 7138104 | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrentl... | 11/21/2006 |
| 7138246 | Methods for identifying or screening for agents that modulate 17β-HSD3 Methods for determining whether a test agent inhibits a 17β-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17β-HSD3; obtaining a reaction mixture comprising the 17β-HSD3, androstenedione, and the test agent; measuring the amoun... | 11/21/2006 |
| 6960474 | Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and u... | 11/01/2005 |
| 6887673 | Humanized antibodies against human 4-1BB A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effe... | 05/03/2005 |
| 6884608 | Compositions and methods for hydroxylating epothilones Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing the... | 04/26/2005 |
| 6838074 | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrentl... | 01/04/2005 |
| 6808698 | Method for localization of blood clots A method wherein a radiolabelled compound is localized at a thrombus. Two-dimensional images, representing a physical property associated with the radiolabelled thrombus, are acquired and assembled into a three-dimensional matrix of data. The three-dimensional matri... | 10/26/2004 |
| 6795776 | Crystallographic structure of the androgen receptor ligand binding domain The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonis... | 09/21/2004 |
| 6794518 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer ... | 09/21/2004 |
| 6773696 | Contrast agent comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 08/10/2004 |
| 6770259 | Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation The present invention provides novel diagnostic compositions comprising a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, diagnostic kits comprising such compositions, and methods of concurrent imaging in a mammal comprising administering... | 08/03/2004 |
| 6743412 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer... | 06/01/2004 |
| 6713042 | Ascorbic acid analogs for metalloradiopharmaceuticals The invention relates to the use of ascorbic acid analogs as buffering reagents and chelating agents for the preparation of metalloradiopharmaceuticals. Also, invention relates to the use of ascorbic acid as a buffering reagent, a chelating agent, and a stabilizer f... | 03/30/2004 |
| 6689337 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d --Ln --Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present ... | 02/10/2004 |
| 6685914 | Macrocyclic chelants for metallopharmaceuticals This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and radiotherapy. This invention relates especially to the use... | 02/03/2004 |
| 6683163 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful fo... | 01/27/2004 |
| 6656448 | Matrix metalloproteinase inhibitors Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties;a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targetin... | 12/02/2003 |
| 6623981 | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states This invention relates to the detection of patients at risk for developing integrin antagonist/agonist mediated disease states. This invention relates to assays useful for the detection in a patient bodily fluid sample of drug-dependent antibodies which b... | 09/23/2003 |
| 6572840 | Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent Novel contrast agents for ultrasound diagnosis and a reproducible process for making the same are described, wherein the contrast agents comprise a microbubble composition comprising a lipid shell, a stabilizer coated on the lipid shell and perfluoropropa... | 06/03/2003 |
| 6572823 | Apparatus and method for reconstituting a solution An apparatus and method are provided for handling a solution. The apparatus comprises a housing and a vial assembly positioned within an enclosure of the housing. The vial assembly maintains at least one vial within the enclosure of the housing. A valve m... | 06/03/2003 |
| 6565828 | Macrocyclic chelants for metallopharmaceuticals This invention relates to new macrocyclic chelants and metal chelates thereof, methods of preparing the chelants and metal chelates, and pharmaceutical compositions comprising the macrocyclic chelants and metal chelates. This invention relates particularl... | 05/20/2003 |
| 6555133 | Formulation of fast-dissolving efavirenz capsules or tablets using super-disintegrants The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired imm... | 04/29/2003 |
| 6537520 | Pharmaceuticals for the imaging of angiogenic disorders The present invention describes novel compounds of the formula: (Q)d --Ln --Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present ... | 03/25/2003 |
| 6524554 | Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer The present invention provides novel radiopharmaceuticals comprising one to three pentapeptides, X1 X2 X3 X4 X5, independently attached to a metal chelator or bonding moiety, Ch, to which i... | 02/25/2003 |
