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| Number | Title | Issue Date |
| 7723349 | Aza spiro alkane derivatives as inhibitors of metalloproteases The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. T... | 05/25/2010 |
| 7683060 | Triazolotriazines as kinase inhibitors The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pa... | 03/23/2010 |
| 7678798 | Piperazinylpiperidine derivatives as chemokine receptor antagonists The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the... | 03/16/2010 |
| 7425630 | Processes for preparing pyrazolo[3,4-d]pyrimidine ethers The present invention relates to processes for preparing pyrazolo[3,4-d]pyrimidine ether compounds that are modulators of glucose metabolism and therefore useful in the treatment of metabolic disorders such as diabetes and obesity. ... | 09/16/2008 |
| 7132426 | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or trea... | 11/07/2006 |
| 6953787 | 5HT2C receptor modulators The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.... | 10/11/2005 |
| 6894045 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands Compounds provided herein are novel substituted tetrahydropurinones of Formula (I): wherein R3 is aryl substituted with 0-5 XAr or heteroaryl substituted with 0-4 XhAr. Such compounds a... | 05/17/2005 |
| 6818648 | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof The present invention provides novel compounds, and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsey, irritable bowl sy... | 11/16/2004 |
| 6787315 | Methods for identifying ligand binding sites in a biomolecule Methods of identifying ligand binding sites in a target molecule such as a polynucleotide or polypeptide, as well as methods for determining whether a particular site in a target molecule is at or near the ligand binding site, are provided. Ligand binding affinities... | 09/07/2004 |
| 6750344 | Amine compounds and combinatorial libraries comprising same The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with build... | 06/15/2004 |
| 6730484 | Methods for identifying ligand binding sites in a biomolecule Methods of identifying ligand binding sites in a target molecule such as a polynucleotide or polypeptide, as well as methods for determining whether a particular site in a target molecule is at or near the ligand binding site, are provided. Ligand binding affinities... | 05/04/2004 |
| 6730485 | Methods for identifying ligand binding sites in a biomolecule Methods of identifying ligand binding sites in a target molecule such as a polynucleotide or polypeptide, as well as methods for determining whether a particular site in a target molecule is at or near the ligand binding site, are provided. Ligand binding affinities... | 05/04/2004 |
| 6525056 | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders Corticotropin releasing factor (CRF) antagonists of Formula (I): ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as wel... | 02/25/2003 |
| 6521636 | Imidazo-pyridines as corticotropin releasing factor antagonists The present invention describes novel imidazo-pyridines of formula I: ##STR1## wherein D is aryl or heteroaryl or pharmaceutically acceptable salt forms thereof, which are useful as corticotropin releasing factor antagonists.... | 02/18/2003 |
| 6518271 | 1H-imidazo[4,5-d]pyridazin-7-one, and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and coloni... | 02/11/2003 |
| 6509338 | Pyrazolo[1,5-A]triazine corticotropin releasing factor antagonists The present invention describes novel pyrazolo[1,5-a]triazines of formula: ##STR1## wherein R3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.... | 01/21/2003 |
