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| Number | Title | Issue Date |
| 7396679 | Oncolytic adenovirus Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promote... | 07/08/2008 |
| 7307071 | RAF-MEK-ERK pathway inhibitors to treat cancer Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bc... | 12/11/2007 |
| 7078030 | Oncolytic adenovirus Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promote... | 07/18/2006 |
| 7001596 | Oncolytic adenovirus Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promote... | 02/21/2006 |
| 6890747 | Phosphoinositide 3-kinases The present invention relates PI3K crystals, polypeptide muteins, polypeptide fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods of modifying PI3Kγ activity, and methods of modulating PI3Kγ activity. These include polypeptides and ... | 05/10/2005 |
| 6764674 | Adenovirus E1B shuttle vectors Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution therefore of a heterologous gene that substantially exhibits the temp... | 07/20/2004 |
| 6762284 | Nucleotide sequences that encode phosphatidylinositol-3′ kinase associated proteins and uses thereof Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3′kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino acids, and... | 07/13/2004 |
| 6723316 | Herpes simplex virus-1 Glycoprotein C mutants for treating unwanted hyperproliferative cell growth The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex virus, which is cytopathic to susceptible target cells, such as neoplastic cells. Preferably, the virus does not produce a funct... | 04/20/2004 |
| 6682920 | Compositions and methods for identifying PKB kinase inhibitors Compositions and methods are described that are useful to assay for compouds that affect PKB kinase activity which have medical applications for the diagnosis and treatment of disease.... | 01/27/2004 |
| 6660259 | Herpes simplex virus for treating unwanted hyperproliferative cell growth The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex-type 1 virus, which is cytopathic to susceptible hyperproliferative cells, such as neoplastic cells. Preferably, the ... | 12/09/2003 |
| 6635244 | Adenovirus E1B-55K single amino acid mutants and methods of use Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for trea... | 10/21/2003 |
| 6569655 | Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustr... | 05/27/2003 |
| 6558918 | Nucleic acid that encode a cell growth regulatory protein Compositions of matter consisting of a family of related nucleic acid sequences that encode proteins, termed Cell Growth Regulatory Proteins, that phosphorylate cell cycle targets, and methods of using the nucleotide sequences and the proteins encoded the... | 05/06/2003 |
| 6511825 | Cell signaling polypeptides and nucleic acids The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, in... | 01/28/2003 |
| 6500653 | Nucleic acids and polypeptides which resemble RHO and which interact with cell signaling pathways and proteins The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction... | 12/31/2002 |
| 6428960 | Selection method for producing recombinant baculovirus The present invention provides a novel method for producing recombinant baculoviruses expressing genes of interest by inserting a selectable marker gene, specifically the puromycin resistance (pac) gene, adjacent to the gene of interest into the baculovir... | 08/06/2002 |
| 6391630 | Plasmids that encode green fluorescent protein Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that... | 05/21/2002 |
| 6296845 | Selective killing and diagnosis of p53+ neoplastic cells Methods and compositions for treating and diagnosing neoplastic disease using viruses are provided. Preferably, mutant adenovirus lacking viral proteins which bind and/or inactivate p53 are administered to a patient having a neoplasm which comprises cells... | 10/02/2001 |
| 6225060 | Baculovirus expression system and method for high throughput expression of genetic material The present invention provides novel recombinant baculovirus expression systems for expressing foreign genetic material in a host cell. Such expression systems are readily adapted to an automated method for expression foreign genetic material in a high th... | 05/01/2001 |
| 6133419 | Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3' kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino ... | 10/17/2000 |
| 6133243 | Liposomal-viral DNA complexes for treating disease Methods and compositions for treating cancer consisting of viral DNA in association with liposomal material, the viral DNA substantially incapable of encoding a functional viral oncoprotein capable of binding to a functional tumor suppressor gene product ... | 10/17/2000 |
| 6080578 | Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a... | 06/27/2000 |
| 5972706 | Cytopathic viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a... | 10/26/1999 |
| 5948643 | Modulators of BRCA1 activity Compositions of matter consisting of a family of related nucleotide sequences that encode proteins, termed BRCA1 Modulator Proteins, that bind to the tumor suppressor gene product BRCA1, and methods of using the nucleotide sequences and the proteins encod... | 09/07/1999 |
| 5876711 | Methods and compositions for determining the tumor suppressor status of cells Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that... | 03/02/1999 |
| 5856181 | Cytopathic viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a... | 01/05/1999 |
| 4771128 | Method of purifying toxin conjugates using hydrophobic interaction chromatography A method of isolating and purifying toxin conjugates using hydrophobic interaction chromatography. Crude conjugate mixtures are sized to remove unconjugated toxin, and loaded onto a column filled with a suitable hydrophobic gel. Elution is effected with s... | 09/13/1988 |
