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| Number | Title | Issue Date |
| 7297682 | Diphosphate salt of a 4″—substituted-9-deoxo-9 A—AZA—homoerythromycin derivatives and its pharmaceutical composition This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopryanosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideo... | 11/20/2007 |
| 7214677 | Benzamide, heteroarylamide and reverse amides The present invention relates to novel to P2X7 inhibitors of formula I and to processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, an... | 05/08/2007 |
| 6887472 | Anti-IgE vaccines The present invention provides compositions and methods for the use of antigenic peptides derived from the Fc portion of the epsilon heavy chain of an IgE molecule as vaccines for the treatment and prevention of IgE-mediated allergic disorders. In particular, the in... | 05/03/2005 |
| 6841671 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutica... | 01/11/2005 |
| 6833378 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined... | 12/21/2004 |
| 6800734 | Leptospira vaccine antigens for the prevention of Leptospirosis Four antigenic preparations are provided, each of which contains a different protein from Leptospira which can be used immunologically in vaccines for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding these four prote... | 10/05/2004 |
| 6777393 | 4″-substituted-9-deoxo-9a-aza-9a homoerythromycin a derivative The invention relates to a method of preparing compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial an... | 08/17/2004 |
| 6777404 | Use of corticotropin releasing factor antagonists and related compositions The present invention relates to compositions and methods of achieving a therapeutic effect including, the treatment or prevention of Syndrome X in an animal, preferably a mammal including a human subject or a companion animal, using a corticotropin releasing factor... | 08/17/2004 |
| 6765008 | Pyrrolopyrimidines as CRF antagonists The compounds of the formula wherein R1, R2, R3, R4, R5 and R6 are as defined herein, are useful in the treatment of stress-related and other diseases. Th... | 07/20/2004 |
| 6759393 | Growth hormone and growth hormone releasing hormone compositions The present invention relates to methods and compositions of growth hormone and/or growth hormone releasing hormone that promote of the release and the elevation of growth hormone when administered to animals. The present invention further relates to methods and com... | 07/06/2004 |
| 6750231 | 4-arylpiperidine derivatives for the treatment of pruritus There is provided a compound of formula I, wherein Het1, R1, R2, R3, X and n have meanings given in the description, which are useful in the prophylaxis and in the treatment of... | 06/15/2004 |
| 6733754 | Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ... | 05/11/2004 |
| 6710071 | Difluoromethylene aromatic ethers as inhibitors of glycine transport This invention relates to a series of difluoromethylene aromatic ethers of the formula wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmace... | 03/23/2004 |
| 6699862 | Indolyl-2-phenyl bisamidines useful as antiproliferative agents Novel indolyl-2-phenyl bisamidines are described which are DNA methyltransferase inhibiting agents, and pharmaceutical compositions containing them are used as antiproliferative agents for treating a disease, especially a neoplastic disease, characterized... | 03/02/2004 |
| 6693226 | Transgenic mice expressing human p25 The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a p25 (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (... | 02/17/2004 |
| 6645982 | Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethy nyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxybutanedioate salts and method of production The invention relates to crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethy nyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxy butanedioate salts having the formula shown below: ##STR1## and to pharmaceutica... | 11/11/2003 |
| 6635270 | NMDA receptor agonist pharmaceutical compositions This invention relates to stable pharmaceutical compositions of the NMDA receptor agonist, (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propano l], methods of preparing such pharmaceutical compositions and methods of treating str... | 10/21/2003 |
| 6630472 | Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic az... | 10/07/2003 |
| 6627755 | Quinazolin-4-one AMPA antagonists The present invention relates to novel quinazolin-4-one derivatives of the formula ##STR1## wherein A is a benzo or thieno fused aromatic ring; B is phenyl, pyridyl or pyrimidyl; X is N or CH; and Y-Z is --CH2 NH-- or --NHCH2 --; ... | 09/30/2003 |
| 6610711 | 4-phenylpiperidines for the treatment of pruritic dermatoses Novel compounds having general formula (I), and pharmaceutically and veterinarily acceptable salts thereof wherein R1, R2, R3, W, Y1, Y2, X, n and y are as defined above and processes for their prepar... | 08/26/2003 |
| 6288246 | Process for preparing hydroxamic acids The present invention relates to a process for preparing hydroxamic acids from hydroxylic acid intermediates wherein the carboxylic acid intermediate does not possess reactive substituents such as hydroxy or amino groups.... | 09/11/2001 |
| 6245765 | Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihyd ro-2(1H)-indol-2-one (=ziprasidone), its preparation and its use as dopamine D2 antagonist The invention is directed to the mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydr o-2H-indol-2-one, pharmaceutical compositions containing said ziprasidone mesylate dihydrates, and methods of adminsiter... | 06/12/2001 |
| 6245745 | Hygromycin A derivatives This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X1 and X2 are as defined herein. The compounds of formula... | 06/12/2001 |
| 6245321 | Cyclodextrins in dental products Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl &#x... | 06/12/2001 |
| 6245766 | Method of treating psychiatric conditions A method for treating a psychiatic condition or disorder selected from anxiety disorders such as panic disorder, posttraumatic stress disorder and phobias, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders such as ... | 06/12/2001 |
| 6242438 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof. Such compounds and salts are tachykinin antagonists. ##STR1##... | 06/05/2001 |
| 6242461 | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases This invention relates to novel aryl substituted azabenzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof. ##STR1## or a pharmaceutically acceptable salt thereof wherein n is an integer from 1 to 4 X is CH or N; R1 is H, (C | 06/05/2001 |
| 6239285 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems A process is described for preparing a compound of Formula (1.3.0): ##STR1## comprising: establishing a reaction mixture consisting of ##STR2## in an aprotic solvent; in the presence of NaOH or KOH; optionally in the presence of a phase transfer catalyst,... | 05/29/2001 |
| 6239147 | 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives This invention relates to novel 1-trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives of the formula ##STR1## wherein R1 is C1 -C6 alkyl; R2 is hydrogen, C1 -C6 alkyl, hal... | 05/29/2001 |
| 5852038 | Substituted 3-aminoquinuclidines | 12/22/1998 |
| 5734053 | Purinone antianginal agents | 03/31/1998 |
| 4868301 | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains Oxophthalazinyl acetic acids having aldose reductase inhibitory properties of the formula ##STR1## wherein Z is hydrogen or methyl, U is S, CH2 or a covalent bond, and R1, R3, R4, R5 and R6 | 09/19/1989 |
| 4863948 | Isoindolinone sulfonamide anti-arrhythmic agents A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkylamine derivatives have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic moiety is a 5- or 6-membered nitrogen-containing heterocyc... | 09/05/1989 |
| 4861779 | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids Antibacterial compounds have the formula ##STR1## wherein R1 is hydrogen, a pharmaceutically acceptable cation, or alkyl; A is CH, CF, CCl or N; Y is alkyl, haloalkyl, cyclopropyl, vinyl, methoxy, N-methylamino, p-fluorophenyl, p-hydroxyph... | 08/29/1989 |
| 4855500 | Process for preparing a ketimine An improved condensation process for preparing N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine from 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone and methylamine is disclosed. The process involves the use of a hydratable... | 08/08/1989 |
| 4851130 | Oxygen removal with carbon catalyzed erythorbate or ascorbate When an aqueous system containing dissolved oxygen and erythorbate or ascorbate is passed through an activated carbon bed, the oxygen is removed at ambient temperatures. This method of oxygen removal finds practical application in the removal of oxygen fr... | 07/25/1989 |
| 4839104 | Process for preparing sertraline intermediates A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the inter... | 06/13/1989 |
| 4835165 | Antiarrhythmic 4-phenylpiperidines A cardiac antiarrhythmic agent of the formula: ##STR1## or a pharmaceutically acceptable salt thereof; wherein R is R3 SO2 NH--, R3 CONH-- or R1 R2 NSO2 --; R1 and R2 ... | 05/30/1989 |
| 4829071 | Quinolyl substituted indane sulfonamides and their use as anti-arrhythmic agents Novel 5-alkanesulphonamido-2-[N-(alkanesulphonamidoheterocyclicmethyl-N-methylam ino]indane compounds have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. The heterocyclic moiety present i... | 05/09/1989 |
| 4829062 | Benzothiazine dioxide derivatives A series of novel oxyalkyl ether derivatives of various enolic oxicam compounds have been prepared, including certain novel enol oxyalkyl ethers of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (piroxicam). These partic... | 05/09/1989 |
