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| Number | Title | Issue Date |
| 8163718 | Nucleoside analogues containing phosphonate or phosphonamide groups Novel compounds having structure (1) wherein Z, is N or CH to form a purine, Y, R1, R2′ and R2 are defined in the specification, are provided for use in the treatment of tumors and ... | 04/24/2012 |
| 8158810 | ALDH-2 inhibitors in the treatment of addiction Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing age... | 04/17/2012 |
| 8124764 | Fused heterocyclyc inhibitor compounds The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compoun... | 02/28/2012 |
| 8088754 | Anti-proliferative compounds, compositions, and methods of use thereof Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1... | 01/03/2012 |
| 8071581 | Triazolopyridazine protein kinase modulators The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by kinase activity. ... | 12/06/2011 |
| 8049013 | 5- [4-(azetidin-3-yloxy)-phenyl]-2-phenyl-5H-thiazolo[5,4-C] pyridin-4-one derivatives and their use as MCH receptor antagonists The present invention relates to a melanin concentrating hormone antagonist compound of formula I: wherein “-----” is absent or is optionally a bond; q is 1 or 2; R1 is independently selected from hydrogen, —C1-C2 alkyl, halo, ... | 11/01/2011 |
| 8030302 | Amidophenoxyindazoles useful as inhibitors of c-Met The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer. ... | 10/04/2011 |
| 7994164 | Mineralocorticoid receptor antagonists and methods of use The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or e... | 08/09/2011 |
| 7977481 | Pyrimidinyl-thiophene kinase modulators The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity. ... | 07/12/2011 |
| 7968587 | Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treat... | 06/28/2011 |
| 7902372 | Opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mi... | 03/08/2011 |
| 7902356 | Thiazolopyridinone derivates as MCH receptor antagonists The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable sal... | 03/08/2011 |
| 7846960 | FXR agonists Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. ... | 12/07/2010 |
| 7863302 | Compounds and methods for modulating FX-receptors Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. ... | 01/04/2011 |
| 7838543 | MCH receptor antagonists The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acce... | 11/23/2010 |
| 7749992 | Compounds and methods for treating dislipidemia Compounds of formula I wherein n, m, p, q, y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are di... | 07/06/2010 |
| 7560463 | Diaryl ethers as opioid receptor antagonists Compound 5-(2-Methoxy-4-{[2-(tetrahydro-pyran-4-yl)-ethylamino]-methyl}-phenoxy)-pyrazine-2-carboxamide or a pharmaceutically acceptable salt thereof, useful for the treatment of irritable bowel syndrome. ... | 07/14/2009 |
| 7531557 | Diaryl ethers as opioid receptor antagonists Compound 6-(2-fluoro-4-[[2-(tetrahydro-pyran-4-yl)-ethylamino]-methyl]-phenoxy)-nicotinamide, or a pharmaceutically acceptable salt thereof, is useful for the treatment of alcoholism. ... | 05/12/2009 |
| 7470705 | Compounds and methods for treating dyslipidemia The present invention discloses compounds of formula (I) wherein A, n, q, K, W, X, Y; Z, R1, R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are d... | 12/30/2008 |
| 7414132 | Opioid receptor antagonists A compound of the formula (I); wherein the variables X1 to X10, R1 to R7 including R3′, E, W, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereom... | 08/19/2008 |
| 7399774 | 6-substituted nicotinamide derivatives as opioid receptor antagonists A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as des... | 07/15/2008 |
| 7396943 | Opioid receptor antagonists A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed. | 07/08/2008 |
| 7381719 | Diaryl ethers as opioid receptor antagonist A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer o... | 06/03/2008 |
| 7381750 | Amino-phenoxymethyl-benzamide opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, R1 to R7 including R3′, j, k, p, y, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful fo... | 06/03/2008 |
| 7378448 | Diphenylether amide derivatives as opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mi... | 05/27/2008 |
| 7288543 | Opioid receptor antagonists A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3′, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the trea... | 10/30/2007 |
| 7229987 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obes... | 06/12/2007 |
| 7217727 | Phospholipase inhibitors A novel class of 3-oxo-3H-benzo[d]isoxazole carboxamide compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lip... | 05/15/2007 |
| 7196100 | Opioid receptor antagonists A compound of the formula (I) wherein the variables X1 to X5, R1 to R7 including R3′, E, q, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer... | 03/27/2007 |
| 7160909 | Cyclopenta[b]indole derivatives as sPLAinhibitors A novel class of tricyclic compounds of the following formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/09/2007 |
| 7109231 | Cyclohept[b]indole derivatives A novel class of tricyclic compounds of the following formula (I): (formula I); is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock | 09/19/2006 |
| 7026348 | Indole sPLA2 inhibitors A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock. ... | 04/11/2006 |
| 7012153 | Process for preparing benzoic acids An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent. ... | 03/14/2006 |
| 6992100 | sPLAinhibitors A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/31/2006 |
| 6974831 | sPLA2 inhibitors A novel class of cycloalkyl fused indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 12/13/2005 |
| 6939890 | sPLA2 inhibitors A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 09/06/2005 |
| 6933313 | Substituted carbazoles as inhibitors of sPLA2 Carbazoles of formula (I) with R2=hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. | 08/23/2005 |
| 6930123 | sPLA2 inhibitors A novel class of benz[f]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 08/16/2005 |
| 6916840 | Spla2 inhibitors A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 07/12/2005 |
| 6872743 | sPLA2 inhibitors A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 medi... | 03/29/2005 |
