Genentech, Inc. - US Patent Attorneys and Agents

Attorney: Genentech, Inc.

Number of patents: 29
Last date: May 01, 2012

Number	Title	Issue Date
8168645	Arylsulfonamide compounds The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biol...	05/01/2012
8163763	Pyrimidine compounds, compositions and methods of use Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseas...	04/24/2012
8163518	Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry. ...	04/24/2012
8148106	Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. T...	04/03/2012
8138152	Methods of treatment using WISP polypeptides The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration ...	03/20/2012
8071097	Apoptotic anti-IgE antibodies The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders. ...	12/06/2011
8063218	Imidazopyridine inhibitors of IAP The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein Q, X1, X2, Y, Z R1, R2, R3, R3′...	11/22/2011
7989595	Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ...	08/02/2011
7951916	Il-1 related polypeptides The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric p...	05/31/2011
7947813	Polyelectrolyte precipitation and purification of proteins Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte. ...	05/24/2011
7855275	Cysteine engineered antibodies and conjugates Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody frag...	12/21/2010
7695928	Disheveled PDZ modulators The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators. ...	04/13/2010
7662926	Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor The present application describes antibodies that selectively bind human FcγRIIB, with little or no binding to other human FcγRs, e.g., human FcγRIIA. The invention also provides isolated bispecific antibodies comprising an antibody that selectively binds FcγRII...	02/16/2010
7632658	Method of using aminopeptidase to produce cleaved polypeptides A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of the yfcK gene and encodes an aminopeptidase. Alternatively, a gram-negat...	12/15/2009
7595399	Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM. ...	09/29/2009
7582445	Anti-interferon-α antibodies Compositions of matter encoding or useful for expressing anti-interferon alpha antibodies are provided. Methods of using such compositions of matter for producing anti-interferon alpha antibodies are also provided. ...	09/01/2009
7579448	Purification of microbial cell fermentation homogenates A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the broth or homogenate an effective amount of a solution of 6,9-diamino-2-...	08/25/2009
7572447	Methods and compositions for selective modulation of vascularization The invention provides methods and compositions for modulating vascularization and angiogenesis, including selective modulation of stages of multi-step vascularization and angiogenesis. ...	08/11/2009
7494977	Polypeptides homologous to VEGF and BMP1 The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF inclu...	02/24/2009
7407660	Methods and compositions for selective modulation of vascularization The invention provides methods and compositions for modulating vascularization and angiogenesis, including selective modulation of stages of multi-step vascularization and angiogenesis. ...	08/05/2008
7227004	Antibodies to vascular endothelial cell growth factor The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related protein. The invention also provides hybridoma cell lines that produce suc...	06/05/2007
7169901	Anti-VEGF antibodies Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo. ...	01/30/2007
7060269	Anti-VEGF antibodies Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo. ...	06/13/2006
7038017	Antibody purification A process for purifying an antibody is provided. In this process, a mixture containing the antibody and a contaminant is subjected to low pH hydrophobic interaction chromatography (LPHIC) at low salt concentration. The antibody is eluted from the column in the fract...	05/02/2006
6994856	ErbB4 receptor-specific neuregulin related ligands and uses therefor The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention...	02/07/2006
6884879	Anti-VEGF antibodies Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo. ...	04/26/2005
6472585	Cardiotrophin-1 defective mouse The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tum...	10/29/2002
6121428	Protein recovery The invention herein provides a method for recovering a polypeptide comprising exposing a composition comprising a polypeptide to a reagent which binds to, or modifies, the polypeptide, wherein the reagent is immobilized on a solid phase; and then passing...	09/19/2000
6099841	Hepatocyte growth factor receptor agonists and uses thereof Hepatocyte growth factor (HGF) receptor agonists are provided. The HGF receptor agonists include HGF receptor antibodies and fragments thereof. The HGF receptor agonists can be employed to substantially enhance HGF receptor activation. The HGF receptor ag...	08/08/2000

PatentStorm

Bizarre Patents

PatentStorm News

Attorney: Genentech, Inc.