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| Number | Title | Issue Date |
| 8114581 | Methods and compositions for detecting neoplastic cells Methods and compositions for identifying neoplastic cells in a biological sample are provided. ... | 02/14/2012 |
| 8112157 | Magnetic material-containing microfabricated devices for wireless data and power transfer This disclosure relates to the design and fabrication of micro-electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields for wireless data and power transfer. ... | 02/07/2012 |
| 8110898 | Polymer-embedded semiconductor rod arrays A structure consisting of well-ordered semiconductor structures embedded in a binder material which maintains the ordering and orientation of the semiconductor structures. Methods for forming such a structure include forming the semiconductor structures on a substra... | 02/07/2012 |
| 8076114 | Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45... | 12/13/2011 |
| 8053107 | Feedthrough assembly with compression collar The feedthrough assembly includes an insulating sleeve positioned between a ferrule and a pin such that the ferrule is electrically insulated from the pin. The feedthrough assembly also includes a compression collar compressing the ferrule and insulating sleeve agai... | 11/08/2011 |
| 8053106 | Battery with improved insulator The battery includes a cover assembly on a battery case. The cover assembly includes a battery cover coupled with an electrically insulating flap of material. The battery can include a first electrical connector that provides electrical communication between a termi... | 11/08/2011 |
| 8026284 | Enterically coated cystamine, cysteamine and derivatives thereof The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. ... | 09/27/2011 |
| 8026085 | Methods and systems for selective fluorination of organic molecules A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity. ... | 09/27/2011 |
| 8017408 | Device and methods of detection of airborne agents Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other... | 09/13/2011 |
| 7994226 | Methods of treating non-alcoholic steatohepatitis (NASH) using cysteamine products The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine products. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such ... | 08/09/2011 |
| 7989176 | Treating cancer Provided is a method for screening for effective agents for the treatment of cancer which method comprises selecting a putative agent that is likely to disrupt a function mediated by a critical normal gene product, which function is required for the successful divis... | 08/02/2011 |
| 7972601 | Method of promoting delivery of an antioxidant agent to a cell expression neuroligin Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the e... | 07/05/2011 |
| 7968080 | Somatostatin analogs with inhibitory activity to growth hormone release Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof. ... | 06/28/2011 |
| 7966132 | Methods for remote characterization of an odor Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compos... | 06/21/2011 |
| 7955561 | Colloidal particles used in sensing array Chemical sensors for detecting analytes in fluids comprising a plurality of alternating nonconductive regions (comprising a nonconductive material) and conductive regions (comprising a conductive material). In preferred embodiments, the conducting region comprises a... | 06/07/2011 |
| 7939287 | Methods of identifying a subject having or at risk of having or developing coronary artery disease Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD). ... | 05/10/2011 |
| 7910461 | Method for reuse of wafers for growth of vertically-aligned wire arrays Reusing a Si wafer for the formation of wire arrays by transferring the wire arrays to a polymer matrix, reusing a patterned oxide for several array growths, and finally polishing and reoxidizing the wafer surface and reapplying the patterned oxide. ... | 03/22/2011 |
| 7906281 | Method to predict the response to lithium treatment The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment. ... | 03/15/2011 |
| 7873198 | Methods and apparatus for determining proportions of body materials The present invention provides an apparatus and methods for measuring proportions of body materials in body parts. The apparatus includes a device for retaining the body part, at least one reference material with at least two thicknesses positioned adjacent to the d... | 01/18/2011 |
| 7863030 | Regio- and enantioselective alkane hydroxylation with modified cytochrome P450 Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydro... | 01/04/2011 |
| 7851228 | Methods for screening agents that modulate presenilin activity and A-β production The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease. ... | 12/14/2010 |
| 7802572 | Face mask A medical face mask comprising a central transparent portion, an outer filter portion and, optionally, one or more antimicrobial agents is described. ... | 09/28/2010 |
| 7786081 | Peptide composition Provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in stimulating fibroblasts to produce fibrillin, wherein the peptide comprises an amino acid sequence present in an α-S2 casein precursor, said sequence compris... | 08/31/2010 |
| 7777000 | Anti-viral activity of cathelicidin peptides The disclosure provides methods and compositions useful in the treatment of dermatitis and viral infections. The compositions comprise cationic peptides of the cathelicidin family including LL-37, related homologues, and variants thereof. ... | 08/17/2010 |
| 7776823 | Human cathelicidin antimicrobial peptides Provided are peptide and peptide consensus sequences, which inhibit bacterial growth and/or viral growth and mimic the activity of LL-37, CRAMP, and/or FALL-39. The peptides are useful as antimicrobials, anti-inflammatories and antiviral agents. ... | 08/17/2010 |
| 7745594 | Nucleic acid-based logic circuits This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein. ... | 06/29/2010 |
| 7745569 | Amyloid specific binding peptides and detecting abeta peptide Phage peptide display technology was used to identify peptides that bind specifically to the amyloid form of the Aβ1-40 peptide. Peptides with similar structural features and bind to the amyloid form of Aβ1-40 but not to monomeric Aβ1-4... | 06/29/2010 |
| 7723063 | Methods for measuring levels of bioactive human hepcidin The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a verteb... | 05/25/2010 |
| 7718618 | Human cathelicidin antimicrobial peptides Provided are peptide and peptide consensus sequences, which inhibit bacterial growth and/or viral growth and mimic the activity of LL-37, CRAMP, and/or FALL-39. The peptides are useful as antimicrobials, anti-inflammatories and anti-viral agents. ... | 05/18/2010 |
| 7704715 | Peroxide-driven cytochrome P450 oxygenase variants The invention relates to novel variants of cytochrome P450 oxygenases. These variants have an improved ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme. These variants also have an improved thermostability as compared to t... | 04/27/2010 |
| 7691616 | Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45... | 04/06/2010 |
| 7684868 | Microfabricated devices for wireless data and power transfer This invention relates to the design and fabrication of micro electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields. ... | 03/23/2010 |
| 7635848 | Edge-on SAR scintillator devices and systems for enhanced SPECT, PET, and compton gamma cameras The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiographic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy... | 12/22/2009 |
| 7598003 | Battery having enhanced energy density The battery includes an electrolyte activating one or more cathodes and one or more anodes. The electrolyte includes one or more organoborate salts in a solvent. The organoborate salt can include a lithium bis[bidentate]borate or a lithium dihalo mono[bidentate]bora... | 10/06/2009 |
| 7595023 | Spatiotemporal and geometric optimization of sensor arrays for detecting analytes in fluids Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array.... | 09/29/2009 |
| 7585952 | Human mini-antibody cytotoxic for tumor cells which express the ErbB2 receptor The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a pharmacological, in particular antitumour, activity. It has been obtained from a larger fagmidic library (Griffin 1.) (19) of human synthetic scFv by p... | 09/08/2009 |
| 7579315 | Casein peptides for alleviating or preventing aging of skin Provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing periodontal disease, wherein the peptide comprises an amino acid sequence present in an α-S2 casein precursor, said sequence compri... | 08/25/2009 |
| 7575873 | Reagents for diagnosing, imaging and treating atherosclerotic disease The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL components of atherosclerotic plaques in vivo and a means to determine the... | 08/18/2009 |
| 7564559 | MEMS-based, phase-shifting interferometer Provided herein are optical devices fabricated to include a reflective surface, actuators and stress-relieving structures. Systems containing such devices, and methods of manufacturing such devices, are also provided. ... | 07/21/2009 |
| 7564120 | Electrical passivation of silicon-containing surfaces using organic layers Electrical structures and devices may be formed and include an organic passivating layer that is chemically bonded to a silicon-containing semiconductor material to improve the electrical properties of electrical devices. In different embodiments, the organic passiv... | 07/21/2009 |
