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| Number | Title | Issue Date |
| 8137994 | Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE meta... | 03/20/2012 |
| 8137993 | Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE meta... | 03/20/2012 |
| 8137992 | Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE meta... | 03/20/2012 |
| 8124129 | Crystalline form of the compound A-348441 There is provided a hemihydrate of (3β,5β,7α,12α)-7,12-dihydroxy-3-{2-[{4-[17β-hydroxy-3-oxo-17α-prop-1-ynylestra-4,9-dien-11β-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern havin... | 02/28/2012 |
| 8043526 | Stabilized crosslinking composition This invention relates to a crosslinking composition comprising an organic acid and a compound having the structure of Formula I: A′-NRA—RD wherein A′, RA, and RD are def... | 10/25/2011 |
| 8021681 | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders The present invention is directed to a method of treating a patient suffering from the metabolic syndrome and/or related disorders including obesity, Type 2 diabetes, pre-diabetes, hypertension, dyslipidemia, insulin resistance, endothelial dysfunction, pro-inflamma... | 09/20/2011 |
| 7993848 | Staphylococcus protein A domain mutants that bind to TNF-α A TNF-α binding polypeptide is provided, which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having 1 to about 20 substitution mutations. Nucleic acid encoding the poly... | 08/09/2011 |
| 7993650 | Polypeptides having binding affinity for HER2 A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations... | 08/09/2011 |
| 7956214 | Process for the preparation of aniline-derived thyroid receptor ligands Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands. ... | 06/07/2011 |
| 7947053 | Suturing device and technique A suturing device includes a body member having proximal and distal ends and a longitudinal axis and comprising a slide and trigger slide; a tip assembly attached to the distal end and comprising: a hollow sheath having a window at its distal end; a pushrod in the h... | 05/24/2011 |
| 7939577 | Radiation-curable alkoxy silanized hyperbranched polyester acrylates and preparation thereof The invention provides a radiation-curable alkoxy silanized hyperbranched polyester acrylate, characterized in that the radiation-curable alkoxy silanized hyperbranched polyester acrylate is produced by using a hyperbranched molecule with at least 16 functionalities... | 05/10/2011 |
| 7927510 | Calcium hypochlorite compositions comprising zinc salts and lime The present invention is directed to a granular water treatment composition, comprising: 35-95 wt % calcium hypochlorite; 1 to 50 wt % magnesium sulfate or a hydrate thereof; 0.1 to 10 wt % lime; and 0.1 to 55 wt % of a water soluble zinc salt or a hydrate thereof; ... | 04/19/2011 |
| 7897718 | Acrylated semi-crystalline hyperbranched polyurethane oligomer and preparation method thereof The present invention relates to an acrylated semi-crystalline hyperbranched polyurethane oligomer and a preparation method thereof, which is characterized in that on the basis of the synthesis of hyperbranched polyurethane oligomer, it adopts a two-step process to ... | 03/01/2011 |
| 7868057 | Vegetation basis and method of production thereof The present invention relates to a vegetation basis, which can be molded at low pressure and temperature and further, keep the crumbled structure suitable for plant growth either by means of a viscosity of a sheath-core type fiber or by addition of a hot melt adhesi... | 01/11/2011 |
| 7807778 | Cysteine-containing peptide tag for site-specific conjugation of proteins The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; an... | 10/05/2010 |
| 7807429 | Isolated luciferase gene of The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of Luciola italica, as well as mutants thereof. The luciferase proteins of the present invention have been found to have extended bioluminescence ... | 10/05/2010 |
| 7739091 | Method for estimating protein-protein binding affinities The present invention is directed to a method of predicting the binding affinity between a first molecular entity and a second molecular entity. The method includes (1) calculating the free energy of binding ΔGbind between the first molecular entity and ... | 06/15/2010 |
| 7700557 | Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments The present invention is directed to an isolated polypeptide including: (1) the A subunit of Shiga-like bacterial toxin, wherein said subunit has the nucleic acid sequence of SEQ ID NO:9; and (2) human vascular endothelial growth factor wherein the growth factor has... | 04/20/2010 |
| 7625567 | Induction of immune responses to isoaspartyl-modified antigens The present invention is directed to a method of enhancing the immune response of a patient relative to the normal immune response, by administering isoaspartyl-modified proteins, peptides, or cells, to a patient. The present invention is also directed to vaccines c... | 12/01/2009 |
| 7575673 | Method of water treatment The invention relates to a method of treatment of bodies of water such as recreational pools, spas and hot tubs with maintenance doses of water treatment chemicals to achieve consistent sanitization and aesthetically pleasing levels of properties such as turbidity. ... | 08/18/2009 |
| 7521439 | Glucocorticoid receptor ligands for the treatment of metabolic disorders This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin... | 04/21/2009 |
| 7449280 | Photoimageable coating composition and composite article thereof A photoimagable composition suitable for use as a negative photoresist comprising: (A) at least one epoxidized polyfunctional bisphenol A formaldehyde novolak resin; (B) at least one polycaprolactone polyol reactiv... | 11/11/2008 |
| 7442325 | Stabilized crosslinking composition This invention relates to a crosslinking composition comprising an organic acid and a compound having the structure of Formula I: A′-NRA—RD wherein A′, RA, and RD are defi... | 10/28/2008 |
| 7427418 | Phloridzin-rich phenolic fraction and use thereof as a cosmetic, dietary or nutraceutical agent A phenolic fraction of fruit obtained from the Rosaceae family and also to the process for the specific extraction of this fraction. The phenolic fraction is rich in dihydrochalcones (phloridzin and phloretin) and may be used as a cosmetic, dietary, or nutraceutical... | 09/23/2008 |
| 7410938 | Calcium hypochlorite/scale inhibitor/residue disperser triblend A solid calcium hypochlorite composition comprising a mixture of: solid calcium hypochlorite; a scale-inhibiting effective amount of a primarily scale-inhibiting alkali metal phosphate; and an effective residue-dispersing amount of primarily residue-dispersing alkal... | 08/12/2008 |
| 7396922 | Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase angiogenesis, to stimulate HIF-1α function, to treat hypoxia-related co... | 07/08/2008 |
| 7381698 | Methods for treatment of acute pancreatitis The invention relates generally to methods for treating acute pancreatitis in patients. The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising secretin and a pharmaceutically acceptable carrier. ... | 06/03/2008 |
| 7355019 | Cysteine-containing peptide tag for site-specific conjugation of proteins The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; an... | 04/08/2008 |
| 7319163 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism. ... | 01/15/2008 |
| 7319096 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism... | 01/15/2008 |
| 7288571 | Thyroid receptor ligands and method II New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or dif... | 10/30/2007 |
| 7285298 | Use of a dihydrochalcone-rich phenolic fraction in a cosmetic treatment The use of a dihydrochalcone-rich polyphenolic fraction in the cosmetic treatment of mammals in order to limit the weight, to improve the aesthetic appearance of the body, and to treat certain non-pathological forms of obesity. The use of a dietary or nutraceutical ... | 10/23/2007 |
| 7282324 | Photoresist compositions, hardened forms thereof, hardened patterns thereof and metal patterns formed using them Photoresist compositions that demonstrate superior photolithographic performance and hardened resist films that show superior resistance to solvents, have excellent resistance to under plating during the electrodeposition of metals, and show excellent resist strippi... | 10/16/2007 |
| 7279593 | Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism... | 10/09/2007 |
| 7267973 | Nucleic acids encoding recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor The present invention is directed to an isolated nucleic acid encoding a fusion protein comprising (1) the A subunit of Shiga-like bacterial toxin, or a truncated or mutated version thereof; and (2) human vascular endothelial growth factor, or a truncated or mutated... | 09/11/2007 |
| 7238498 | Screening methods A mammalian polypeptide designated Inhibitory PAS Domain Protein (IPAS) is useful for the inhibition of angiogenesis and/or tumor progression. Screening methods exist to identify compounds potentially useful as medicaments for the treatment of medical conditions rel... | 07/03/2007 |
| 7220752 | Compounds active at the glucocorticoid receptor II This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose ... | 05/22/2007 |
| 7199265 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds and to methods for using such compounds such as in the regulation of m... | 04/03/2007 |
| 7173021 | Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of cancers by topical and transdermal applications, and to a novel process... | 02/06/2007 |
| 7153997 | Benzamide derivatives as thyroid receptor ligands This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which ... | 12/26/2006 |
