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| Number | Title | Issue Date |
| 7244763 | Compounds that modulate PPAR activity and methods of preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic... | 07/17/2007 |
| 7141606 | Gabapentin analogues for sleep disorders The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders. ... | 11/28/2006 |
| 7067262 | Cell line for the expression of an α2δ2 calcium channel subunit and methods of use Described is a method for determining the binding ability of a compound to bind to an α2δ2 subunit of a calcium channel comprising: providing an α2δ2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of t... | 06/27/2006 |
| 7030109 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position The present invention discloses radioligands of 9-arylsulfone of the formula (X) or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders. | 04/18/2006 |
| 7022694 | Indoles and indolines having 5-HT activity The present invention provides compounds of Formula (I): wherein R1, R2, R3, R4, R5, R6 and --- have any of the values defined i... | 04/04/2006 |
| 6984496 | Vitro assay for testing gabapentinoid activity An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activating the MAP kinase signaling pathway, detec... | 01/10/2006 |
| 6958218 | Method for the screening of α2δ-1 subunit binding ligands A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides. ... | 10/25/2005 |
| 6921823 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compound of EXAMPLE 13 whic... | 07/26/2005 |
| 6921835 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 07/26/2005 |
| 6919377 | Cyclohexylamine derivative as subtype selective NMDA receptor antagonists Described are compounds of Formula I and Formula II and their pharmaceutically acceptable salts. The compounds of Formulas I and II are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral isch... | 07/19/2005 |
| 6872856 | Cyclic ketones, their preparation and their use in the synthesis of amino acids A method is provided for making an enantiomerically pure compound of the formula: in which R and R′ represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conju... | 03/29/2005 |
| 6833385 | 3-heteroarylalkyl substituted GABA analogs The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IB... | 12/21/2004 |
| 6828341 | Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists Described are cyclohexylamine derivatives of Formula I and pharmaceutically acceptable salts thereof, wherein R1, g, *, R, V, B, E, Y, G, H, X1, and d are as defined in the description. The compou... | 12/07/2004 |
| 6794402 | Bicyclic cyclohexylamines and their use as NMDA receptor antagonists Described are bicycle-substituted cyclohexylamines of Formula I and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular ... | 09/21/2004 |
| 6765022 | Cyclohexylamine derivatives as subtype selective nmda receptor antagonists Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for treating... | 07/20/2004 |
| 6710190 | 3-heteroarylalkyl substituted gaba analogs The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IB... | 03/23/2004 |
| 6635673 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritabl... | 10/21/2003 |
