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| Number | Title | Issue Date |
| 8158579 | Fusion protein of an exendin to modified transferrin The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and pharmaceutical compositions. The invention also provides the use of the exe... | 04/17/2012 |
| 7652149 | Crystalline pyrazoles The present invention relates to crystal forms of 4-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide and methods for preparation, interconversion, and isolation of such crystals. ... | 01/26/2010 |
| 7622500 | Antiparasitic agents The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents. ... | 11/24/2009 |
| 7608604 | Antiparasitic agents The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2... | 10/27/2009 |
| 7547718 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 06/16/2009 |
| 7544706 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 06/09/2009 |
| 7211565 | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia. ... | 05/01/2007 |
| 7189689 | Apolipoprotein A-L agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia. ... | 03/13/2007 |
| 7157425 | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia. ... | 01/02/2007 |
| 7482368 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for prep... | 01/27/2009 |
| 7407654 | Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of Streptomyces sp. DSMZ 14386, the pharmaceutically acceptable salts and co... | 08/05/2008 |
| 7335799 | Hydroxyl compounds and compositions for cholesterol management and related uses The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular ... | 02/26/2008 |
| 7304093 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a com... | 12/04/2007 |
| 7259241 | gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm... | 08/21/2007 |
| 7192940 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 03/20/2007 |
| 7189411 | Peptide/lipid complex formation by co-lyophilization The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the... | 03/13/2007 |
| 7119221 | Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, card... | 10/10/2006 |
| 6894047 | Triazine compounds useful as sorbitol dehydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of formula I wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to phar... | 05/17/2005 |
| 6664291 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac ... | 12/16/2003 |
| 6657063 | Combinations of 댣 agonists and growth hormone secretagogues This invention is directed to pharmaceutical compositions comprising 댣 adrenergic agonists including (4-(2-(2-(6-aminopyridin-3-yl)-2(R)-hydroxyethylamino)ethoxy)phenyl)acetic acid and growth hormone or growth hormone secretagogues, prod... | 12/02/2003 |
| 6074657 | Administration of an injectable antibiotic in the ear of an animal The present invention provides for a method of injecting an antibiotic in the ear of an animal, such as cattle, swine, sheep and goats. These injectable antibiotics include the following: injectable suspensions of sparingly water-soluble antimicrobial age... | 06/13/2000 |
| 6008253 | Use of 3-guanidinopropionic acid to increase endurance, stamina and exercise capacity in a mammal The present invention provides a new food product and use for a known compound. More particularly, the present invention provides a new food product containing 3-guanidinopropionic acid and a method of using 3-guanidinopropionic acid to increase endurance... | 12/28/1999 |
| 5807582 | Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom The present invention provides for an improvement in the emulsion copolymerization process for the preparation of fine-beaded colestipol hydrochloride (FBCH) wherein the improvement comprises: 1) utilizing a weight ratio of water to polyethylenepolyamine ... | 09/15/1998 |
| 5736510 | Antibiotics 10381v, w, x,y, z1, z2, pre-b and t Antibiotics 10381v, w, x, y, z1, z2, pre-b and t are antibiotics producible by culturing the microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. The structure of Antibiotic 10381y is given below as formula IV. These antibioti... | 04/07/1998 |
| 5736151 | Antibiotic oil suspensions The present invention provides for the inclusion of small amounts of water in oil suspensions of active drugs, such as ceftiofur hydrochloride of formula I. The resulting suspensions have improved resuspendability. Improved resuspendability results in an ... | 04/07/1998 |
| 5721359 | Crystalline ceftiofur free acid Anhydrous and crystalline free acid form of the cephalosporin antiobiotic ceftiofur, processes for its manufacture, and pharmaceutical composition containing it are provided. ##STR1##... | 02/24/1998 |
| 5708169 | 5-amidomethyl ,ଲ-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents The present invention provides for new 5-amidomethyl, ,ଲ-saturated and--unsaturated butyrolactone antibacterial agents of formula I ##STR1## characterized by 3-aryl substituents that include, for example, indolinyl and phenyl substi... | 01/13/1998 |
| 5695984 | Process for the preparation of antibiotics 10381B Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 12/09/1997 |
| 5686486 | 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkylb!pyran-2-ones useful to treat retroviral infections The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkylb!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## Wherein R1... | 11/11/1997 |
| 5616320 | Use of antibiotics 10381b to promote growth Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 04/01/1997 |
| 5585495 | Reduction method for substituted 5-methylene-thiazolidinediones The present invention provides a method for making known pharmaceutical compounds. More particularly the present invention provides a new reduction method for making thiazolidinedione derivatives, particularly ciglitazone, pioglitazone, and englitazone. T... | 12/17/1996 |
| 5520932 | Fine-milled colestipol hydrochloride The present invention provides a novel fine milled form of a known pharmaceutical composition, colestipol hydrochloride. This fine milled form of colestipol hydrochloride yields pharmaceutically elegant dosage forms exhibiting increased potency, including... | 05/28/1996 |
| 5490987 | Tableting of colestipol hydrochloride The present invention provides a novel formulation of matter and a novel process for making it. In particular, the present invention provides unique and novel 1000 mg tablets of Colestipol hydrochloride having the advantageous properties of hardness and l... | 02/13/1996 |
| 5223496 | Cephalosporin antibiotics Cephalosporin compounds of Formulas II ##STR1## where R is hydrogen or a pharmaceutical cation, in which case R1 is not present, or R is hydrogen or a chemical bond when R1 is an acid addition salt anion, and R2 is (a... | 06/29/1993 |
| 5134137 | Cephalosporin antibiotics Cephalosporin compounds of Formulas II ##STR1## where R is hydrogen or a pharmaceutical cation, in which case R1 is not present, or R is hydrogen or a chemical bond when R1 is an acid addition salt anion, and R2 is (a... | 07/28/1992 |
| 5132400 | Peptides containing a (1-amino-2-hydroxy-2-heterocyclic)ethyl moiety The present invention provides novel peptides of the formula X-A6 -B7 -C8 -D9 -E10 -F11 containing a novel (1-amino-2-hydroxy-2-heterocyclic) ethyl moiety of the formula XL2c at ... | 07/21/1992 |
