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| Number | Title | Issue Date |
| 7223867 | Preparation of benzosuberonylpiperidine compounds Diastereoselective and enantioselective synthetic routes for the preparation of compounds of formula (I): or derivatives thereof, wherein: R is C1-6alkyl, C... | 05/29/2007 |
| 6660754 | Method for reducing or eliminating smoking This invention is an improved method for reducing or eliminating tobacco usage and the nicotine dependency associated with tobacco usage by gradually decreasing an individual's tobacco consumption over a time period while replacing nicotine from tobacco w... | 12/09/2003 |
| 6495051 | Methods for preparing blood or plasma component solutions with improved concentrations A method for separating a blood component, e.g., fibrin monomer, from blood or plasma. The method utilizes a container with a reaction chamber for receiving the plasma. The reaction chamber is defined by a wall and an agent is supplied to the reaction cha... | 12/17/2002 |
| 6387263 | Apparatus and methods for preparing plasma solutions from blood with improved separation of plasma An improved plasma separation device and method involve the use of a retaining means with a centrifugal plasma separation device for retaining unwanted blood components, e.g., lipids or lipoproteins, from passing from a separation chamber in the device to... | 05/14/2002 |
| 6359100 | Methods of preparing polyurethane adhesives, adhesives produced thereby and medical devices employing the same A polyurethane adhesive composition preferably having pressure sensitive characteristics that is non-cytotoxic and methods of making the same which is especially useful for medical applications such as ostomy and wound care.... | 03/19/2002 |
| 6262236 | Fibrin sealant compositions and methods for utilizing same The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component ... | 07/17/2001 |
| 5741428 | Rapid centrifugal process for preparing fibrin monomer solution In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical wal... | 04/21/1998 |
| 5527271 | Thermoplastic hydrogel impregnated composite material A composite material for wound dressings having a fibrous wound-contacting substrate, such as cotton gauze, impregnated with a thermoplastic hydrogel forming polymer and methods of making the same.... | 06/18/1996 |
| 5503847 | Hydrocolloid wound gel A hydrocolloid wound gel composition useful for cleansing an debriding wounds and having some capacity for absorbing wound exudate and a method of treating wounds comprising applying the hydrocolloid wound gel to a wound. The composition includes sodium c... | 04/02/1996 |
| 5489531 | Combined two stage method for cleaning and decontaminating surgical instruments A two stage method using the same container for both cleaning and microbiologically decontaminating grossly soiled surgical instruments is described. A presoak in an enzyme solution is followed by direct addition of a compatible disinfectant and a continu... | 02/06/1996 |
| 5445761 | Percarbonate based cleaner for cosmetic and pharmaceutical manufacturing facilities The present invention claims and describes an environmentally sound percarbonate based cleaner for removing cosmetic and pharmaceutical soils from pharmaceutical or cosmetic manufacturing surfaces. The invention includes a combination of a percarbonate; a... | 08/29/1995 |
| 5278169 | Method of treating or prevention of fibrillation of the heart A method for the treatment and prevention of fibrillation using one or more potassium channel activators. Also, disclosed is a process for the preparation of compounds of the formula ##STR1## and the tautomeric forms ##STR2## wherein R''and... | 01/11/1994 |
| 5217958 | 1,2-hydroxy phosphonates and derivatives thereof Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.... | 06/08/1993 |
| 5191086 | Imidazole and benzimidazole derivatives Novel angiotensin-II receptor antagonists are disclosed having the general formula ##STR1## wherein R1, R2, R3, R4, R5, W and X are as defined herein.... | 03/02/1993 |
| 5183653 | Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds Boronic acid adducts of metal dioxime complexes are useful as reagents for labeling proteins and other amine-containing compounds.... | 02/02/1993 |
| 5166143 | Method for preventing onset of restenosis after angioplasty employing an ace inhibitor A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.... | 11/24/1992 |
| 5164509 | Benzodiazolo analogs Novel potassium channel activators of the formula ##STR1## where Y, X, X1, X2 (N or O), and R1 -R4 are as defined herein, are disclosed.... | 11/17/1992 |
| 5153347 | Phosphonate, phosphinate derivatives useful as antihypertensive agents Novel angiotensin II receptor antagonists of the formula ##STR1## wherein X, X1, X2, R1, R2, R3, R4 and R5 are as defined herein, are disclosed. These compounds are useful, ... | 10/06/1992 |
| 5151513 | N-heterocyclic alcohol derivatives Compounds of the formula ##STR1## wherein R1 is an N-heterocyclic group as defined herein, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.... | 09/29/1992 |
| 5140031 | Pyranyl cyanoguanidine derivatives Novel compounds having the formula ##STR1## wherein ##STR2## are disclosed. These compounds have potassium channel activating activity and are useful, for example, as cardiovascular agents, especially as antiischemic agents.... | 08/18/1992 |
| 5137730 | Tablet composition and method for problem pharmaceutical materials using citric acid In accordance with the present invention an improved tablet composition for drugs or active ingredients prone to poor tabletting properties is disclosed. The improved composition comprises a premixture, consisting essentially of between about 85 and 99.9 ... | 08/11/1992 |
| 5118797 | Rhenium tris dioxime complexes Rhenium tris dioxime complexes are useful in the synthesis of boronic acid adducts of rhenium dioxime complexes which are useful as radiotherapeutic agents.... | 06/02/1992 |
| 5106982 | Piperidinyl carbonyl derivatives Novel compounds having the general formula ##STR1## wherein A and A' are amino acid residues linked by a peptidal bond to the nucleus, are disclosed. These compounds are CNS agents with anxiogenic activity.... | 04/21/1992 |
| 5106977 | Intermediates for a process for making 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines Novel intermediates for preparing 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines are disclosed. These intermediates have the formula ##STR1## wherein Prot is as defined herein.... | 04/21/1992 |
| 5081225 | Gram-positive and gram-negative antibacterial compounds from the microorganism, Janthinobacterium lividum A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.... | 01/14/1992 |
| 5069900 | Boronic acid adducts of technetium-99m dioxime-imine complexes Boronic acid adducts of technetium-99m imine-dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species.... | 12/03/1991 |
| 5061813 | Substituted cyanoimino benzopyranes Novel compounds are disclosed having the formula ##STR1## and R1, R2, R3, R4, R5, R6 and R7 are as defined herein. These compounds are useful, for example, as cardiovascular... | 10/29/1991 |
| 5055466 | N-morpholino derivatives and their use as anti-hypertensive agents Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.... | 10/08/1991 |
| 5053504 | Process for benzazepine intermediates A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R3, R4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful ... | 10/01/1991 |
| 5039795 | Preparation of boronic acid derivatives An improved process for preparation of compounds of the formula ##STR1## as disclosed. These compounds are useful as intermediates in the preparation of boronic acid adducts of technetium 99m dioxime complexes of the formula 99m Tc X(Y) | 08/13/1991 |
| 5024839 | Dactylocycline A and dactylocycline B Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.... | 06/18/1991 |
| 5011837 | Aryl cyanoguanidines: potassium channel activators and method of making same Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R2, R3 and R4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity... | 04/30/1991 |
| 5006401 | Composite compression and support dressing In accordance with the present invention a novel composite compression and support dressing is disclosed. This dressing comprises an extensible bandage having a stretchable hydrocolloid adhesive composition laminated thereto.... | 04/09/1991 |
| 5006523 | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.... | 04/09/1991 |
| 4980465 | Process for making 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl)] azetidines and intermediates used therein An improved process for making compounds having the formula ##STR1## includes subjecting an intermediate of the formula ##STR2## to hydrogenolysis in the presence of a ketonic solvent so as to simultaneously remove both Z-protecting groups from ... | 12/25/1990 |
| 4975281 | Anti-ulcer composition In accordance with the present invention a novel oral composition and method of using same for the treatment of ulcers and other gastrointestinal disorders is disclosed. The composition comprises an agent capable of forming an ulcer-adherent protective co... | 12/04/1990 |
| 4965279 | Cyclopropyl aza prostaglandin analogs Novel cyclopropyl aza prostaglandin analogs are disclosed having the formula ##STR1## wherein A can be carbonyl, sulfonyl or a single bond. These compounds are useful, for example, as thromboxane antagonists.... | 10/23/1990 |
| 4965356 | Resolution process for benzazepine intermediates In accordance with the present invention an improved process for preparing resolved compounds of the formula ##STR1## wherein R1 is hydrogen or acetyl.... | 10/23/1990 |
| 4952692 | Benzazepine derivatives Novel compounds of the formula ##STR1## exhibit calcium channel blocking activity and are useful as cardiovascular agents.... | 08/28/1990 |
| 4914245 | Culpin Cultivation of a strain of the microorganism, Preussia sp., that has been deposited in the American Type Culture Collection as A.T.C.C. No. 20,923, yields a novel antibiotic substance, culpin, that has activity against a selected spectrum of microorganism... | 04/03/1990 |
